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News Tips Friday, March 26, 1999

ies: Physician's Health Study, Stanford Five-City Project and the Quebec Cardiovascular Study. They found that for every one nanometer decrease in LDL particle size, heart disease risk increased by 60 percent. When researchers controlled for blood levels of triglycerides and HDL (the "good" cholesterol) the risk was still 30 percent. LDL can range from about 24 to 29 nanometers. Smaller LDL particles may become more easily trapped in blood vessel walls than larger ones. Melissa Austin, Ph.D., University of Washington, Seattle, Ph.:206-685-9384.

12:15 p.m. -- #P96 -- Lipoprotein (a) may be more important for assessing heart disease risk in men than in women. In a study that included African-American and white men and women, researchers at Bassett Healthcare and the Harlem Hospital Center in New York investigated the association between blood levels of lipoprotein (a) -- Lp(a) -- and coronary artery disease (CAD), the cause of heart attacks. The researchers used two different methods to measure blood levels of Lp(a) in 234 individuals with CAD. The standard method of identifying Lp(a) levels with an antibody did not show an association between Lp(a) levels and coronary artery disease. However, when scientists used a another method -- combining two different identifying antibodies instead of just one to measure blood levels of Lp(a) -- they found an association of Lp(a) with increased CAD in both black and white men but not in the women in the study. The researchers contend that their alternate way of measuring Lp(a) can provide additional useful information in determining risk for and severity of coronary artery disease. Herbert Marx, Bassett Healthcare, Cooperstown, N.Y., Ph.: 607-547-3048.

12:15 p.m. -- #P98 -- Current cholesterol screening may misclassify many U.S. children as high risk. A University of Texas study suggests that current cholesterol tests may have returned a "false high" for many children due to a m
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Contact: Carole Bullock
caroleb@heart.org
214-706-1279
American Heart Association
26-Mar-1999


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