News tips for Wednesday, Nov. 12, 2003

2 p.m. Abstract #3544 Results of hormone replacement study get rapid acceptance. Findings of last year's Women's Health Initiative (WHI) trial that hormone replacement therapy (HRT) with estrogen (E) plus progesterone (P) in post-menopausal women leads to excessive risk of cardiovascular disease is resulting in a "clear global decrease" in the use of HRT, a new study finds. Researchers assessed the impact of the WHI publication among 6,623 women, age 55 and over, taking part in an ongoing international drug trial. They found that 3.4 percent of North American women in that study were on E+P HRT after the WHI report, down from 5.9 percent before the report. Their results indicate a rapid acceptance of the results of the WHI trial both in North America and other countries, the scientists say. And despite a lack of data on effects of HRT with E alone, this therapy also was down in North American women, from 26 percent of post-menopausal women before the WHI report to 17.7 percent after.

2:15 p.m. Abstract #3099 Excess daytime sleepiness affects angina patients' quality of life. Sleep disturbances are a common problem among patients with coronary artery disease (CAD). New research finds that excessive daytime sleepiness predicts a poorer quality of life of CAD patients with chronic stable angina (chest pain). The Emory University study of 57 angina patients assessed quality of life (QOL) aspects via standard questionnaires, at baseline and follow-ups of one, three and four months. Extent of daytime sleepiness also was evaluated along with numerous other factors including years with CAD, body mass index and extent of other health problems. After controlling for clinical and demographic variables, researchers found daytime sleepiness to be "a significant negative predictor of QOL" in four statistical models studied. "Daytime sleepiness had pervasive and detrimental effects on chronic angina patients' QOL including generic and disease-s

Contact: Carole Bullock
American Heart Association

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