Nicotine more addictive when combined with other tobacco smoke chemicals, UCI study finds

e-acetaldehyde mixture or either drug alone at levels significantly higher than saline.

Belluzzi and his team also used self-administration tests of cocaine to test the reliability of the novel self-administration procedure and to evaluate whether early adolescence was a period of enhanced vulnerability to other abused drugs. Although adolescent rats are more responsive to the nicotine-acetaldehyde mix than adult rats, the young rats were not more responsive to cocaine than adults.

"Our latest findings suggest that the study of tobacco addiction, as well as the development of smoking cessation treatments, could be improved by studying the interactions of nicotine with other smoke components," Leslie said.


Contact: Tom Vasich
University of California - Irvine

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