nitrosamines, more effective approaches toward prevention of tobacco-related cancers can be designed. Because lung cancer therapy is still largely unsuccessful, the use of chemical agents to inhibit the carcinogenicity of tobacco smoke--called chemoprevention--remains as a viable way to prevent cancer death in addicted smokers and ex-smokers, Hecht adds. Many agents have been tested in mice, and phase I clinical trials for the leading candidate, an isothiocyanate called PEITC, are being initiated.

# # # #

Researcher contact: Dr. Stephen S. Hecht,
612-624-7604 (phone); 612-626-5135 (fax);
hecht002@gold.tc.umn.edu (email);

or Coleen Southwell,
Director of Communications, University of Minnesota Cancer Center
612-626- 1107;
south011@tc.umn.edu

For a copy of an earlier release on Dr. Hecht's research on nitrosamines and environmental tobacco smoke, or a copy of this 45-page review, call Sally Pecor at 202-872-4451.

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Contact: Jim Bohning
j_bohning@acs.org
202/872-6041
American Chemical Society
2-Jun-1998

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