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No adverse effects of aluminium in vaccines

Writing in the February issue of The Lancet Infectious Diseases, Tom Jefferson and colleagues (Cochrane Vaccines Field, Rome, Italy) report that aluminium in vaccines for diphtheria, tetanus, and pertussis causes no serious or long-lasting adverse effects.

Aluminium salts (potassium aluminium sulphate, aluminium sulphate, or aluminium hydroxide) have been used for decades in vaccine formulations as adjuvants (non-specific stimulators of the immune response), and in this role they are vital to the protective efficacy of vaccines. But aluminium has been blamed for side-effects in vaccine recipients, such as local reactions at the site of vaccination and a chronic progressive syndrome called macrophagic myofasciitis. However, replacing aluminium with another adjuvant would be a massive undertaking because all such vaccines would have to be tested in clinical trials and relicensed; besides, no obvious replacement is available.

After an exhaustive trawl of the medical literature for relevant studies, Jefferson and colleagues collected data for a meta-analysis from five published trials. The authors compared adverse events in two settings: vaccines containing aluminium hydroxide versus no adjuvant for children aged up to 18 months, and vaccines containing different types of aluminium versus no adjuvant in children aged 10-16 years. Although aluminium-containing vaccines were more likely than plain vaccines to cause erythema (redness) and induration (hardening of the skin) in young children, and local pain lasting up to 14 days in the older children, there was no evidence that the aluminium-containing vaccines were responsible for serious or long-lasting side-effects.

Jefferson and colleagues recommend-unusually, perhaps, for modern medicine-that no further research be done on this topic.


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Contact: Joe Santangelo
j.santangelo@elsevier.com
212-633-3810
Lancet
28-Jan-2004


Page: 1

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