HOME >> MEDICINE >> NEWS
Non-invasive and invasive breast cancers share the same genetic mutations

Women diagnosed with early stage, noninvasive breast cancer who carry the same mutations in two inherited breast/ovarian cancer genes as women diagnosed with invasive breast cancer, may benefit from high risk treatment, Yale researchers report in the February 23 issue of Journal of the American Medical Association.

The inherited breast/ovarian cancer genes are BRCA1 and BRCA2, which are associated with an increased risk of breast and/or ovarian cancer. The results are part of a fiveyear study of a common form of early stage breast cancer called ductal carcinoma in situ (DCIS). Led by Elizabeth B. Claus, M.D., associate professor in the Department of Epidemiology and Public Health (EPH) at Yale School of Medicine, the Yale team examined genetic and environmental risk factors for the development of DCIS. They genetically tested 369 women with DCIS for alterations in BRCA1 and BRCA2.

"We found that 0.8 percent of these women had diseaseassociated mutations in BRCA1, while 2.4 percent had such mutations in BRCA2," said Claus. "These numbers are similar to those reported for women with more advanced breast cancer."

Claus said women with mutations were more likely to be diagnosed with DCIS at a young age, to have also been diagnosed with ovarian cancer and to have a first degree family member (mother, sister or daughter) diagnosed with breast cancer, particularly at a young age.

"This study highlights the fact that although DCIS is generally associated with a favorable clinical prognosis, it is important to consider women diagnosed with DCIS and with an appropriate personal or family history of breast and ovarian cancer, as potential members of the inherited breast/ovarian cancer syndromes defined by BRCA1 and BRCA2," said Claus. "As such, this subset of DCIS patients should be screened and followed according to highrisk protocols as are similar women diagnosed with invasive breast cancer."


'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
7-Mar-2005


Page: 1

Related medicine news :

1. Drug therapy may be comparable to invasive cardiac procedures for elderly patients with heart attack
2. Stem cells given in minimally invasive procedure improve heart function
3. New stroke prevention therapy as effective as invasive surgery
4. Minimally invasive surgery for heart rhythm abnormality proven effective
5. Denver physician patents minimally invasive technology for hair transplantation surgery
6. Minimally invasive treatment for varicose and spider veins
7. Mayo Clinic led study: Minimally invasive surgery safe, effective for patients with colon cancer
8. Minimally invasive colon cancer surgery is effective
9. A non-invasive treatment for angina does not lead to enhanced athletic performance
10. Minimally invasive breast cancer treatment shows promise
11. Study of hip replacement patients finds 80 percent eligible for minimally invasive surgery

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... ... August 31, 2020 , ... ... outcomes for patients with advanced heart failure, today announced that the company has ... amount of $555,358 from the National Heart, Lung, and Blood Institute of the ...
(Date:8/28/2020)... ... August 28, 2020 , ... Ernst & Young LLP ... an Entrepreneur Of The Year® 2020 Florida Award finalist. Now in its 34th ... deliver innovation, growth and prosperity as they build and sustain successful businesses that ...
(Date:8/28/2020)... ... August 28, 2020 , ... ... to a customized Lighthouse Health & Wellness mobile app and web-portal. NCPCV received ... Motorola Solutions Foundation awards grants each year to organizations, such as Destination Imagination, ...
(Date:8/28/2020)... ... 2020 , ... Integrated Viral Protection (IVP Air) today announced that ... its breakthrough Mobile Biodefense Indoor Air Protection System that is the first system designed ... fully reopen equipped with the filtration system on September 8th. , The IVP ...
(Date:8/28/2020)... ... August 28, 2020 , ... A July 27 ... individuals are at an increased risk of developing severe COVID-19 symptoms. The article ... however, because the same organ systems that the coronavirus attacks are already suffering ...
Breaking Medicine News(10 mins):
(Date:8/31/2020)... ... August 31, 2020 , ... Welltech1, the first Israeli VC ... invested $400,000 in PopBase, one of two start-ups that beat 152 companies in ... (GWI). , The competition was part of the GWI’s The Wellness Moonshot: ...
(Date:8/31/2020)... ... 31, 2020 , ... Cloudticity announced today that Network Products ... winner in the 15th Annual 2020 Network PG’s IT World Awards®. , The ... Network Products Guide honoring achievements of world’s best in organizational performance, product and ...
(Date:8/28/2020)... ... August 28, 2020 , ... ... beauty, bringing a unique perspective and approach. Armed with her qualifications from Ross ... to share her knowledge of the human body with the nation and world. ...
Breaking Medicine Technology:
Cached News: