HOME >> MEDICINE >> NEWS
Non-invasive and invasive breast cancers share the same genetic mutations

Women diagnosed with early stage, noninvasive breast cancer who carry the same mutations in two inherited breast/ovarian cancer genes as women diagnosed with invasive breast cancer, may benefit from high risk treatment, Yale researchers report in the February 23 issue of Journal of the American Medical Association.

The inherited breast/ovarian cancer genes are BRCA1 and BRCA2, which are associated with an increased risk of breast and/or ovarian cancer. The results are part of a fiveyear study of a common form of early stage breast cancer called ductal carcinoma in situ (DCIS). Led by Elizabeth B. Claus, M.D., associate professor in the Department of Epidemiology and Public Health (EPH) at Yale School of Medicine, the Yale team examined genetic and environmental risk factors for the development of DCIS. They genetically tested 369 women with DCIS for alterations in BRCA1 and BRCA2.

"We found that 0.8 percent of these women had diseaseassociated mutations in BRCA1, while 2.4 percent had such mutations in BRCA2," said Claus. "These numbers are similar to those reported for women with more advanced breast cancer."

Claus said women with mutations were more likely to be diagnosed with DCIS at a young age, to have also been diagnosed with ovarian cancer and to have a first degree family member (mother, sister or daughter) diagnosed with breast cancer, particularly at a young age.

"This study highlights the fact that although DCIS is generally associated with a favorable clinical prognosis, it is important to consider women diagnosed with DCIS and with an appropriate personal or family history of breast and ovarian cancer, as potential members of the inherited breast/ovarian cancer syndromes defined by BRCA1 and BRCA2," said Claus. "As such, this subset of DCIS patients should be screened and followed according to highrisk protocols as are similar women diagnosed with invasive breast cancer."


'"/>

Contact: Karen N. Peart
karen.peart@yale.edu
203-432-1326
Yale University
7-Mar-2005


Page: 1

Related medicine news :

1. Drug therapy may be comparable to invasive cardiac procedures for elderly patients with heart attack
2. Stem cells given in minimally invasive procedure improve heart function
3. New stroke prevention therapy as effective as invasive surgery
4. Minimally invasive surgery for heart rhythm abnormality proven effective
5. Denver physician patents minimally invasive technology for hair transplantation surgery
6. Minimally invasive treatment for varicose and spider veins
7. Mayo Clinic led study: Minimally invasive surgery safe, effective for patients with colon cancer
8. Minimally invasive colon cancer surgery is effective
9. A non-invasive treatment for angina does not lead to enhanced athletic performance
10. Minimally invasive breast cancer treatment shows promise
11. Study of hip replacement patients finds 80 percent eligible for minimally invasive surgery

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology:
Cached News: