HOME >> MEDICINE >> NEWS
Non-pathogenic bacteria block inflammatory response pathway in intestinal tract

A team of Emory University pathologists has discovered that non-pathogenic bacteria within the gastrointestinal tract may be responsible for blocking an immune pathway that otherwise could cause an unhealthy inflammatory response to the millions of bacteria normally present in the intestine. A breakdown in this mechanism for bacterial tolerance could play a fundamental role in the pathogenesis of inflammatory bowel disease (Crohn's disease and ulcerative colitis) and other infectious intestinal diseases. The research was reported in the September 1 issue of the journal Science.

The gastrointestinal tract of humans and other vertebrates is home to a delicate bacterial balancing act in which a diverse ecosystem of non-pathogenic bacteria co-exist among potential pathogens, all under the watchful guard of protective immune cells. Although the intestinal non-pathogenic bacteria, or normal flora, are known to play a biological role in enabling the breakdown of certain vitamins and other substances, scientists have generally believed these bacteria to be otherwise inert residents of the GI tract. The usually harmonious co-existence between intestinal organisms and immune cells dates back through millions of years of evolution, from the time of the earliest known vertebrates.

The Emory team of pathologists, including Andrew Neish, M.D., James Madara, M.D. and Andrew Gewirtz, Ph.D., and their colleagues, discovered that non-pathogenic bacteria in the G.I. tract are not merely the innocent intestinal wallflowers they were presumed to be, but that they actually deliver a signal that blocks an important immune-system pathway called NF-KB -- a transcription factor involved in activating genes in the immune system.

"It's fascinating that the epithelium (lining of the intestine) can tolerate the presence of this density of bacteria while also being quite permeable to nutrients and fluids," says Dr. Neish. "Almost all other tissue types in the body are exq
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
31-Aug-2000


Page: 1 2

Related medicine news :

1. Oral bacteria may predict pregnancy outcomes
2. Study finds direct association between cardiovascular disease and periodontal bacteria
3. Substance protects resilient staph bacteria
4. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
5. Bacteria-killing vs. bacteria-inhibiting drugs in treating infections
6. Patients undergoing weight loss surgery have high rates of H pylori bacteria
7. Outbreak of skin infections sheds light on risk factors for bacterial resistance
8. Popular chewing gum eliminates bacteria that cause bad breath
9. Antibiotic resistant bacteria frequently transmitted between intensive care patients
10. New weapon to combat resistant bacteria
11. High level of antibiotic resistance in bacteria that cause food poisoning

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/9/2016)... , ... December 09, 2016 , ... ... through the Pennsylvania Cable Network (PCN) during the summer of 2016. The program ... Grant provided by the United States Department of Health and Human Services Administration. ...
(Date:12/8/2016)... ... December 08, 2016 , ... ZyDoc , a ... and Conventional Data Capture Methods for Input to Electronic Health Records: A Comparative ... of the comparative usability study demonstrate that a dictation-based method (“NLP Entry”) using ...
(Date:12/8/2016)... ... December 08, 2016 , ... David J. Dykeman ... law firm Greenberg Traurig, LLP, will speak at DeviceTalks West, Dec. 12, 2016, at ... DeviceTalks series, and attorneys from the firm’s global Life Sciences & Medical Technology Group ...
(Date:12/8/2016)... , ... December 08, 2016 , ... ... Center has been recognized for adherence to the highest standards of trauma, ... accreditation organizations, announced the center's president and CEO, Dr. Daniel Messina. , Among ...
(Date:12/8/2016)... ... December 08, 2016 , ... Vida Health, the digital ... B led by Canvas Ventures . Other investors include Nokia Growth Partners (NGP) ... platform to serve more consumers who are managing chronic conditions or simply ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... 2016 Research and Markets has announced the ... offering. ... The global chromatography market to grow at a CAGR ... 2016-2020, has been prepared based on an in-depth market analysis with inputs ... prospects over the coming years. The report also includes a discussion of ...
(Date:12/8/2016)... India , December 8, 2016 ... report "Sugar-Based Excipients Market by Product (Actual Sugars, ... Functionality (Filler & Diluent, Tonicity Agents), Formulation (Oral, ... by MarketsandMarkets, the market has witnessed healthy growth ... grow at a CAGR of 4.3% between 2016 ...
(Date:12/8/2016)... SAN FRANCISCO, Calif. , Dec. 8, 2016 ... nuclease technology to develop novel antiviral therapeutics, today ... M.D., as chief executive officer and a member ... is an incredibly experienced executive with a deep ... said Stephen Quake, D.Phil., founder of Agenovir, co-president ...
Breaking Medicine Technology:
Cached News: