HOME >> MEDICINE >> NEWS
Non-pathogenic bacteria block inflammatory response pathway in intestinal tract

A team of Emory University pathologists has discovered that non-pathogenic bacteria within the gastrointestinal tract may be responsible for blocking an immune pathway that otherwise could cause an unhealthy inflammatory response to the millions of bacteria normally present in the intestine. A breakdown in this mechanism for bacterial tolerance could play a fundamental role in the pathogenesis of inflammatory bowel disease (Crohn's disease and ulcerative colitis) and other infectious intestinal diseases. The research was reported in the September 1 issue of the journal Science.

The gastrointestinal tract of humans and other vertebrates is home to a delicate bacterial balancing act in which a diverse ecosystem of non-pathogenic bacteria co-exist among potential pathogens, all under the watchful guard of protective immune cells. Although the intestinal non-pathogenic bacteria, or normal flora, are known to play a biological role in enabling the breakdown of certain vitamins and other substances, scientists have generally believed these bacteria to be otherwise inert residents of the GI tract. The usually harmonious co-existence between intestinal organisms and immune cells dates back through millions of years of evolution, from the time of the earliest known vertebrates.

The Emory team of pathologists, including Andrew Neish, M.D., James Madara, M.D. and Andrew Gewirtz, Ph.D., and their colleagues, discovered that non-pathogenic bacteria in the G.I. tract are not merely the innocent intestinal wallflowers they were presumed to be, but that they actually deliver a signal that blocks an important immune-system pathway called NF-KB -- a transcription factor involved in activating genes in the immune system.

"It's fascinating that the epithelium (lining of the intestine) can tolerate the presence of this density of bacteria while also being quite permeable to nutrients and fluids," says Dr. Neish. "Almost all other tissue types in the body are exq
'"/>

Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University Health Sciences Center
31-Aug-2000


Page: 1 2

Related medicine news :

1. Oral bacteria may predict pregnancy outcomes
2. Study finds direct association between cardiovascular disease and periodontal bacteria
3. Substance protects resilient staph bacteria
4. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
5. Bacteria-killing vs. bacteria-inhibiting drugs in treating infections
6. Patients undergoing weight loss surgery have high rates of H pylori bacteria
7. Outbreak of skin infections sheds light on risk factors for bacterial resistance
8. Popular chewing gum eliminates bacteria that cause bad breath
9. Antibiotic resistant bacteria frequently transmitted between intensive care patients
10. New weapon to combat resistant bacteria
11. High level of antibiotic resistance in bacteria that cause food poisoning

Post Your Comments:
(Date:4/17/2014)... vaccine brands for children may not be the most ... factors when choosing vaccines, driving the market toward what ... new study by University of Illinois researchers. , "The ... numerous factors," says Sheldon H. Jacobson, a co-author of ... of mathematics at the U. of I. "In an ...
(Date:4/17/2014)... Diego School of Medicine report that older women, plucky ... loss are more likely to be compassionate toward strangers ... in this month,s issue of the International Journal ... associated with better health and well-being as we age, ... the outcomes of individuals whose deficits in compassion put ...
(Date:4/17/2014)... Pediatrician-in-Chief Jon McCullers, MD, was recently invited to ... Nature Reviews Microbiology , one of the ... world-renowned infectious disease specialist, and chair of the ... Health Science Center, analyzed the epidemiology and microbiology ... pandemics, as well as more recent 2009 novel ...
(Date:4/17/2014)... who treat patients with a severe and progressive ... agonizing treatment decision. , The drug sirolimus can ... shortness of breath. But some patients eventually may ... fatal complications following transplantation. , "It,s a terrible ... of Loyola University Medical Center,s LAM Clinic and ...
(Date:4/17/2014)... IL, April 17, 2014-- Colic affects about one in ... for numerous pediatric visits during the first several months ... colic symptoms was showing promise; however, the April 1, ... (BMJ2014;348:g2107; Sung, Valerie) reported on a study, "Probiotics and ... L reuteri for infant colic did ...
Breaking Medicine News(10 mins):Health News:Study recalculates costs of combination vaccines 2Health News:The ilk of human kindness 2Health News:Patients with rare lung disease face agonizing treatment dilemma 2Health News:Patients with rare lung disease face agonizing treatment dilemma 3Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2
(Date:1/15/2014)... NEW YORK , Jan. 15, 2014 ... research report is available in its catalogue: ... - India Drug Forecast and Market Analysis ... PharmaPoint: Atopic Dermatitis - India ...
(Date:1/15/2014)... Jan. 15, 2014  A novel wearable injector slightly larger than ... for patients to self-inject prescription drugs in the large doses ... blood diseases, autoimmune deficiencies, and genetic disorders.  ... $220B by 2018, according to analysts.   Many of these drugs ...
(Date:1/14/2014)... Healthcare Services, Inc. ("DHS"), a portfolio company of GMH Ventures ... Equipment, Inc. ("Progressive") of Clarion, PA ... not disclosed. Progressive is a full service ... sleep, mobility, and respiratory products to customers in the western ...
Breaking Medicine Technology:PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 2PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 4PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 5Enable Injections Presents A New Class of Injectors for Drug Delivery at PEPTalk, Drug Delivery Partnership Meetings 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3
Cached News: