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Northwestern on trail of gene mutations that trigger sex reversal

elieves that the Northwestern study will reveal much-needed information about how the genes regulate gonad development as well as about gonadal dysgenesis and infertility in humans.

They also will make the animals available to the scientific community for future research.

"Defects in these genes can presumably cause not only overt sex reversal XY females and XX males but also much milder manifestations of sex reversal disorder," Weiss said.

Thus far, Jameson and Weiss have focused on the Sry gene and another gene called DAX1 that also is believed to play an important in role in development of the testes.

The new gene research project will build on the ENU mutagenesis program developed at the NIH-funded Neurogenomics Center at Northwestern University by Joseph S. Takahashi, who cloned the first mammalian circadian gene, Clock. Takahashi, who directs the center, is professor of neurobiology and physiology and of neurology.


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Contact: Elizabeth Crown
e-crown@northwestern.edu
312-503-8928
Northwestern University
15-Jan-2003


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