HOME >> MEDICINE >> NEWS
Novel Imaging Agent Developed By Penn Researchers Provides Insight Into Brain's Message Delivery System

at are linked to dopamine changes."

Dopamine transporters are protein complexes ocated at the presynaptic (forepart) of dopamine nerve terminals which function to deliver messages to receptors in the brain. A significant reduction in the density of these transporters has been found in postmortem examinations of the brains of Parkinson's and Alzheimer's patients. Thus, measurement of the dopamine transporter with Trodat could be a useful indicator of dopamine neural loss. With advanced radiologic imaging technology, such as single positron emission tomography (SPET) -- which works by emitting photons or light -- Trodat can be a valuable tool for live diagnosis and treatment of illnesses associated with dopamine transporters. Such illnesses include Parkinson's and Alzheimer's, as well as schizophrenia and ALS (Lou Gehrig's disease).

In this study, Trodat was intravenously injected into rats. Trodat displayed specific brain uptake in the rats' striatal region of the brain where dopamine neurons are concentrated. The study's findings strongly support the conclusions that Trodat binds selectively to dopamine transporters in the brain and that it is potentially useful in the assessment of neuron loss. Compared to other imaging agents, Trodat is favorable because it involves very little radioactivity, has a six-hour physical half-life, and is inexpensive. This tracer, coupled with SPET imaging, can provide diagnostic information not attainable by other imaging techniques, including early indications of diseases associated with dopamine changes. Research continues into more advanced stages with goals to ultimately translate findings into clinical applications for patients. Recently, research has progressed to human studies using Trodat.

The University of Pennsylvania Health System is dedicated to developing leaders in science and medicine through education, research, and quality patient ca
'"/>

Contact: Diane Giaccone
dgiaccon@mail.med.upenn.edu
(215) 662-2098
University of Pennsylvania School of Medicine
25-Aug-1998


Page: 1 2 3

Related medicine news :

1. Novel therapy tested in mice could chase away cat allergies
2. Novel antibiotic shows promise in shortening treatment duration of tuberculosis
3. Novel p53 gene-based therapy boosts immune system and reduces tumor size
4. Novel drugs help solve Gleevec resistance
5. Novel imaging technique shows abnormal brain anatomy in children with ADHD
6. Novel drug-antidote strategy provides greater control of drug action
7. Novel imaging technique shows lymph nodes, metastases in breast cancer without surgery
8. Novel delivery method for nutrients wins Kaye Innovation Award for Hebrew university students
9. Novel vitamin discovery offers clues for cancer chemotherapy and lipid disorders
10. Novel findings about neovessel formation
11. Novel MRI technique provides clear images of blood flow

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/4/2016)... Gilmer, TX (PRWEB) , ... May 04, 2016 ... ... commencement of a master charity program created to assist the people of their ... working closely with nonprofit organizations and community leaders. Their hope is to bring ...
(Date:5/4/2016)... ... May 04, 2016 , ... May kicked off with Melanoma Monday , ... Dermatologist Dr. Ellen Turner is encouraging her patients, as well as residents all around ... safety and health now and in the future. , The dermatology-specific awareness month ends ...
(Date:5/4/2016)... CA (PRWEB) , ... May 04, 2016 , ... Dr. ... offering wisdom tooth removal surgery at their office. Wisdom tooth removal, a common dental ... not always problematic, they often are improperly erupted, resulting in risks of complications. By ...
(Date:5/4/2016)... ... 2016 , ... Nordic Naturals announces another breakthrough innovation—Omega Curcumin, ... synergistic combination of omega-3 fatty acids and potent antioxidants contains 1000 mg concentrated ... and 200 mg of N-Acetylcysteine (NAC). , Each nutrient plays a distinct ...
(Date:5/4/2016)... , ... May 04, 2016 , ... Francesca Loparco, Co-Founder ... her life forever with a same-day LASIK procedure at Christenbury Eye Center. ... Dr. Jonathan Christenbury performed her surgery the same day as her in-office consultation and ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... , May 3, 2016 ... INTP), a clinical-stage biopharmaceutical company, today announced the appointment ... and Regulatory Affairs. "Ms. Strauss-Levy has 15 ... and has established an outstanding track record, having supported ... and regulatory approval processes in the United ...
(Date:5/3/2016)... , May 3, 2016 ... bekannt, dass sie einen entscheidenden Meilenstein durch ... Ein Aufruf zum Handeln, um Patientenresultate  bei ... trägt zu Fortschritten im Verständnis der Hepatischen ... ein Bewusstsein für Hepatische Enzephalopathie in der ...
(Date:5/2/2016)... May 2, 2016  Deerfield announced today it ... Graybug Vision, Inc. Graybug Vision is an early ... may transform care for ocular diseases including wet ... technology was first developed at Johns Hopkins University ... venture. Graybug Vision is developing ...
Breaking Medicine Technology:
Cached News: