HOME >> MEDICINE >> NEWS
Novel Imaging Agent Developed By Penn Researchers Provides Insight Into Brain's Message Delivery System

at are linked to dopamine changes."

Dopamine transporters are protein complexes ocated at the presynaptic (forepart) of dopamine nerve terminals which function to deliver messages to receptors in the brain. A significant reduction in the density of these transporters has been found in postmortem examinations of the brains of Parkinson's and Alzheimer's patients. Thus, measurement of the dopamine transporter with Trodat could be a useful indicator of dopamine neural loss. With advanced radiologic imaging technology, such as single positron emission tomography (SPET) -- which works by emitting photons or light -- Trodat can be a valuable tool for live diagnosis and treatment of illnesses associated with dopamine transporters. Such illnesses include Parkinson's and Alzheimer's, as well as schizophrenia and ALS (Lou Gehrig's disease).

In this study, Trodat was intravenously injected into rats. Trodat displayed specific brain uptake in the rats' striatal region of the brain where dopamine neurons are concentrated. The study's findings strongly support the conclusions that Trodat binds selectively to dopamine transporters in the brain and that it is potentially useful in the assessment of neuron loss. Compared to other imaging agents, Trodat is favorable because it involves very little radioactivity, has a six-hour physical half-life, and is inexpensive. This tracer, coupled with SPET imaging, can provide diagnostic information not attainable by other imaging techniques, including early indications of diseases associated with dopamine changes. Research continues into more advanced stages with goals to ultimately translate findings into clinical applications for patients. Recently, research has progressed to human studies using Trodat.

The University of Pennsylvania Health System is dedicated to developing leaders in science and medicine through education, research, and quality patient ca
'"/>

Contact: Diane Giaccone
dgiaccon@mail.med.upenn.edu
(215) 662-2098
University of Pennsylvania School of Medicine
25-Aug-1998


Page: 1 2 3

Related medicine news :

1. Novel therapy tested in mice could chase away cat allergies
2. Novel antibiotic shows promise in shortening treatment duration of tuberculosis
3. Novel p53 gene-based therapy boosts immune system and reduces tumor size
4. Novel drugs help solve Gleevec resistance
5. Novel imaging technique shows abnormal brain anatomy in children with ADHD
6. Novel drug-antidote strategy provides greater control of drug action
7. Novel imaging technique shows lymph nodes, metastases in breast cancer without surgery
8. Novel delivery method for nutrients wins Kaye Innovation Award for Hebrew university students
9. Novel vitamin discovery offers clues for cancer chemotherapy and lipid disorders
10. Novel findings about neovessel formation
11. Novel MRI technique provides clear images of blood flow

Post Your Comments:
(Date:3/29/2015)... (PRWEB) March 29, 2015 Pro Ace ... the company will now provide qualified HVAC technicians that ... their heat pumps and related systems throughout Vancouver, North ... furnaces and air conditioners, heat pumps require regular maintenance ... experts such as BC Hydro strongly suggest you have ...
(Date:3/29/2015)... Metamora, MI. (PRWEB) March 29, 2015 ... offers comprehensive menopause treatment. Secondary to their location ... a closer hospital option. They continue to be ... Oakland. , Menopause is a normal condition ... "menopause" can describe any of the changes a woman ...
(Date:3/29/2015)... Karnataka (PRWEB) March 30, 2015 ... receipt of the coveted NABH Accreditation on 11th ... Board for Hospitals and Healthcare Providers) comes as ... quality care standards of Telerad RxDx., With Telerad ... to be accredited for NABH, marks a major ...
(Date:3/29/2015)... 2015 The Contract Research Organizations ... research, manage data results and help develop and ... regulation standards. Contract research organizations (CROs) mainly serve ... sectors. Industry operators provide clients with a full ... research for Food and Drug Administration (FDA) approval. ...
(Date:3/29/2015)... March 29, 2015 Youth Villages will ... in Oregon to assess the feasibility of implementing a ... and behavioral problems and their families. , Third Sector ... participants that will be provided technical assistance throughout 2015 ... join six other national awardees chosen by Third Sector. ...
Breaking Medicine News(10 mins):Health News:Pro Ace Care Now Provides Qualified HVAC Technicians for Heat Pump Maintenance 2Health News:Women's Excellence Affiliates with Beaumont Hospital, Treats Menopause 2Health News:NABH Accreditation for Telerad RxDx – Whitefield. 2Health News:Contract Research Organizations in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Contract Research Organizations in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Contract Research Organizations in the US Industry Market Research Report from IBISWorld Has Been Updated 4Health News:Youth Villages Partners with Two Oregon Counties to Advance Pay-for-Success Model to Help At-Risk Youth 2Health News:Youth Villages Partners with Two Oregon Counties to Advance Pay-for-Success Model to Help At-Risk Youth 3Health News:Youth Villages Partners with Two Oregon Counties to Advance Pay-for-Success Model to Help At-Risk Youth 4
(Date:3/27/2015)... 2015  The quality function within the medical device ... quality standards at every stage of the product life ... also have the challenge of balancing quality and safety ... don,t effectively balance these priorities risk funding and staffing ... and regulatory scrutiny. For the third consecutive ...
(Date:3/27/2015)... 27, 2015 Object recognition technology has a ... and elderly. The VelaSense ® mobile ... more independent, productive and fulfilling lives. VelaSense ® ... users to identify objects from a one million object ... customized object databases for personal use. ...
(Date:3/27/2015)... - Russell Williams , President of ... 2015-2016 Quebec Budget, noting the fiscal discipline and the ... However, the association is concerned about the decline of ... intent to strive for a balanced budget this year, ... Quebec,s economic development is encouraging," said Mr. ...
Breaking Medicine Technology:New Medical Device Quality Study Finds Regulatory Environment is Boosting Quality Spending, Especially for Large Companies 2VelaSense Object Recognition Technology for the Blind was unveiled at Baruch College's CCVIP 8th Annual Conference 2Quebec 2015-2016 Budget: Rx&D welcomes fiscal discipline and biopharma working group, but the decrease in government spending on medicines is questioned 2Quebec 2015-2016 Budget: Rx&D welcomes fiscal discipline and biopharma working group, but the decrease in government spending on medicines is questioned 3
Cached News: