HOME >> MEDICINE >> NEWS
Novel Therapy To Treat Lung Cancer Patients Enrolling Patients At UCSF Cancer,,Center

Researchers at the UCSF Cancer Center are recruiting patients with advanced lung cancer for a clinical trial of a novel drug that they hope will inhibit the growth and spread of cancer.

The drug, developed by Agouron Pharmaceuticals, Inc., is one of the first agents in a new class of therapies that have been shown to inhibit the actions of a natural body chemical, called Matrix Metalloproteases (MMPs), that breaks down the material between cells to make room for new cellular growth.

There is good reason for enthusiasm about this drug because the preliminary data looks favorable and suggests that MMPs inhibitors (MMPIs) are effective in slowing tumor growth, said David Jablons, MD, UCSF assistant professor of surgery and principal investigator of the study.

The inhibitors are also well tolerated because they are taken in pill form and have minimal side effects. In a normal, healthy body, MMPs play an important role in such processes as fetal development, ovulation, wound healing, and cell growth and regeneration.

However, when too many MMPs are produced or are present at the wrong time, they can break down the material, known as extracellular matrix, that holds cells together inside tissues.

This activity occurs in diseases in which healthy tissue is broken down or unhealthy tissue grows, as in cancer and rheumatoid arthritis, Jablons said.

Cancer tumors grow and spread, interfering with the functions of healthy tissue. Some MMPs have been shown to play a significant role in tumor development by contributing to three processes that lead to the progression of cancer: invasion, metastasis, and angiogenesis.

Cancer researchers believe that a MMPI, called AG3340, will block these processes while limiting the damage that may result from a broad suppression of MMPs.

Invasion is the expansion of tumors into neighboring healthy tissue. MMPs act to break down the matrix structure of the healthy tissue, paving the way for the invading malign
'"/>

Contact: Abby Sinnott
(415) 885-7277
University of California - San Francisco
19-Aug-1998


Page: 1 2

Related medicine news :

1. Novel therapy tested in mice could chase away cat allergies
2. Novel antibiotic shows promise in shortening treatment duration of tuberculosis
3. Novel p53 gene-based therapy boosts immune system and reduces tumor size
4. Novel drugs help solve Gleevec resistance
5. Novel imaging technique shows abnormal brain anatomy in children with ADHD
6. Novel drug-antidote strategy provides greater control of drug action
7. Novel imaging technique shows lymph nodes, metastases in breast cancer without surgery
8. Novel delivery method for nutrients wins Kaye Innovation Award for Hebrew university students
9. Novel vitamin discovery offers clues for cancer chemotherapy and lipid disorders
10. Novel findings about neovessel formation
11. Novel MRI technique provides clear images of blood flow

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2021)... , ... March 29, 2021 , ... ... the 21st Century , A Virtual Workshop Presented by WCG FDAnews and Cerulean ... 4:30 pm EDT, https://wcg.swoogo.com/modern-sop-and-quality-systems , Are one’s SOPs written for the ...
(Date:3/30/2021)... ... March 29, 2021 , ... According to data released ... reproductive age (13-44) in need of publicly funded contraception live in counties impacted by ... Colorado’s 64 counties have lost some of their Title X resources. , The ...
(Date:3/30/2021)... ... March 29, 2021 , ... Health Literacy Innovations (HLI), a ... confusion due to low health literacy today announces a new partnership with the ... work with ACAP’s member Safety Net Health Plans, those that provide comprehensive health ...
(Date:3/30/2021)... ... ... Dr. Colin Campbell is proud to announce the 1 year anniversary in their new state ... internal medicine and is a primary care specialist who has been practicing for 23 years. ... keep South Jersey healthy one patient at a time. , “Over the past year, Dr. ...
(Date:3/30/2021)... ... March 30, 2021 , ... The COVID-19 ... and survivors; their families; and their caregivers. Crossroads4Hope is addressing the needs of ... emotional support system, MyGo2Support, which meets needs of people impacted by cancer, no ...
Breaking Medicine News(10 mins):
(Date:3/30/2021)... ... March 29, 2021 , ... The University of Texas Health Science Center ... San Antonio Multispecialty and Research Hospital, a destination center for research and treatment of ... In a nod to the COVID-19 pandemic, the ceremony was held virtually. , William ...
(Date:3/30/2021)... ... March 29, 2021 , ... Iora Health ... primary care, has partnered with Devoted Health , one of the fastest-growing ... across Maricopa County and provides seniors with the highest-quality care and experience possible, ...
(Date:3/30/2021)... CITY (PRWEB) , ... March 29, 2021 , ... ... has joined the Vaccine Credential Initiative (VCI), a group bringing together leading health ... record of vaccination status, based on open, interoperable standards. By joining the VCI ...
Breaking Medicine Technology:
Cached News: