HOME >> MEDICINE >> NEWS
Novel antibiotic shows promise in shortening treatment duration of tuberculosis

medicines each day under the supervision of a healthcare worker.

R207910 Study Findings

"Our findings suggest that at least in mice, R207910 seems to have the desired properties of simplifying and shortening the treatment duration, and perhaps, more," says Andries. In bacterial cell cultures, R207910 was effective against many different strains of mycobacteria, including strains that are resistant to other drugs. The drug is bactericidal, meaning that it kills the TB bacilli.

In mouse models, the studies showed that a cocktail regimen containing this compound reduced bacterial load after one month to the same level as the currently used regimen after two months of treatment, shortening normal treatment time by 50 percent. After two months treatment with the R207910 containing cocktail, no TB bacilli could be isolated from the lungs anymore, a finding that the French group that did those studies called "unprecedented".

The mouse studies also show that this new compound quickly enters the bloodstream and is actually concentrated in lung cells-which harbour the TB bacilli-killing the bacilli soon after they enter the body. Also, R207910 lingers in the body for days continuing to kill bacilli even when administered only once a week in mice.

R207910 is unique in the way it works. The compound attacks an enzyme called ATP synthase, the energy source for the bacterium. Given its new mechanism of action and apparent impact on drug resistant strains of TB, according to Andries, R207910 could lead to a shift in the current treatment paradigm for tuberculosis. "Preliminary data show R207910 has the desired properties we need and holds a great deal of promise," he said.

However, Koen added, considerable work needs to be done to fully determine this compound's clinical potential. Since the compound seems to be safe and well tolerated in Phase I studies with healthy human volunteers, R207910 will now be tested in humans
'"/>


9-Dec-2004


Page: 1 2 3 4

Related medicine news :

1. Novel therapy tested in mice could chase away cat allergies
2. Novel p53 gene-based therapy boosts immune system and reduces tumor size
3. Novel drugs help solve Gleevec resistance
4. Novel imaging technique shows abnormal brain anatomy in children with ADHD
5. Novel drug-antidote strategy provides greater control of drug action
6. Novel imaging technique shows lymph nodes, metastases in breast cancer without surgery
7. Novel delivery method for nutrients wins Kaye Innovation Award for Hebrew university students
8. Novel vitamin discovery offers clues for cancer chemotherapy and lipid disorders
9. Novel findings about neovessel formation
10. Novel MRI technique provides clear images of blood flow
11. Novelty-seeking teens may be more easily influenced by tobacco advertisements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/14/2020)... , ... February 14, 2020 , ... ... Overview of Chiropractic Care During Pregnancy. The guide breaks down the benefits of ... to ScripHessco, “Receiving chiropractic care during pregnancy is quite beneficial to the mother’s ...
(Date:2/14/2020)... ... 14, 2020 , ... “The American Society for Dermatologic Surgery ... discoloration, and lines and wrinkles. And the treatments they are most interested in ... in February specifically to address the areas our patients are most concerned about,” ...
(Date:2/13/2020)... ... February 13, 2020 , ... The ... Virginia: Arlington, Dulles-Aldie, Fair Oaks, Fairfax, Fredericksburg, Leesburg, and Woodbridge, as well as ... Virginia-based fertility specialists have been named as Top Docs for Infertility by Northern ...
(Date:2/11/2020)... NEW YORK (PRWEB) , ... February 11, 2020 , ... ... of Radiology Benefit Management (RBM), but the service that truly raises us above our ... reviewer and medical director is a board-certified Radiologist with years of clinical experience. We ...
(Date:2/11/2020)... ... February 11, 2020 , ... Dental ... is pleased to announce a $5,000 grant to provide free dental care for ... generously donated to the Smiles for Everyone Foundation , which provides free ...
Breaking Medicine News(10 mins):
(Date:2/16/2020)... ... 16, 2020 , ... In Partnership with the Smiles for Everyone Foundation ... WA office. , A limited number of appointments are available, but there is plenty ... or to schedule an appointment, please call (509)-820-4302. , Who: Bright Now! Dental, Where: ...
(Date:2/15/2020)... ... February 14, 2020 , ... February ... between the organisms that cause inflammatory gum disease (e.g., periodontitis) and systemic inflammatory ... , offers new tools in the fight against common dental problems such as ...
(Date:2/14/2020)... ... 2020 , ... Dignitana AB , world leader in scalp cooling innovation, ... sponsor three signature events in 2020 with Susan G. Komen®. The sponsorship extends Dignitana’s ... the Cure® and MORE THAN PINK Walk® events in key Dignitana markets throughout year. ...
Breaking Medicine Technology:
Cached News: