HOME >> MEDICINE >> NEWS
Novel coronavirus confirmed as causative agent of SARS

Leading scientists worldwide investigating the cause of Severe Acute Respiratory Syndrome (SARS) confirm that a novel coronavirus is the primary cause of the disease. The study is published on THE LANCET's website (http://www.thelancet.com) at 0001 H Tuesday 22 July UK time.

SARS was first reported in China in November 2002, with over 8300 cases and 812 deaths reported by the beginning of July 2003. A novel coronavirus has been identified as the likely cause of SARS. Albert Osterhaus from Erasmus University, Rotterdam, Netherlands, and colleagues investigated the causal role of this newly discovered SARS-associated coronavirus (SARS-CoV) by analysis of the results of international investigations done by the WHO network of laboratories.

Clinical and postmortem samples were tested from 436 SARS patients in six countries for infection with SARS-CoV, human metapneumovirus, and other respiratory pathogens. As criteria for indentifying the primary cause of a disease include the production of a comparable disease in the original host or a related species, the investigators infected four macaques (Cynomolgus monkeys common in south-east Asia) with SARS-CoV. Necropsies were done on the sixth day after infection.

SARS-CoV infection was diagnosed in three-quarters of patients fitting the case definition of SARS; human metapneumovirus was diagnosed in 12% of cases and other respiratory pathogens were diagnosed only sporadically. The four SARS-CoV-infected macaques excreted SARS-CoV from nose, mouth, and pharynx from 2 days after infection.

Three of four macaques developed lung damage (diffuse alveolar damage), similar to that in SARS patients. SARS-CoV was detected in the alveolar areas of the lung by virus isolation from immunohistochemistry, transmission electron microscopy, and genetic assessment by polymerase chain reaction,.

Albert Osterhaus comments: "Collectively, these results of laboratory
'"/>

Contact: Joe Santangelo
j.santangelo@elsevier.com
212-633-3810
Lancet
21-Jul-2003


Page: 1 2

Related medicine news :

1. Novel therapy tested in mice could chase away cat allergies
2. Novel antibiotic shows promise in shortening treatment duration of tuberculosis
3. Novel p53 gene-based therapy boosts immune system and reduces tumor size
4. Novel drugs help solve Gleevec resistance
5. Novel imaging technique shows abnormal brain anatomy in children with ADHD
6. Novel drug-antidote strategy provides greater control of drug action
7. Novel imaging technique shows lymph nodes, metastases in breast cancer without surgery
8. Novel delivery method for nutrients wins Kaye Innovation Award for Hebrew university students
9. Novel vitamin discovery offers clues for cancer chemotherapy and lipid disorders
10. Novel findings about neovessel formation
11. Novel MRI technique provides clear images of blood flow

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Novel coronavirus confirmed causative agent SARS

(Date:8/27/2014)... one of the most loved online bamboo product suppliers; the ... Recently, it has announced its new selection of bamboo ... to offer one-stop shopping solutions for people who want to ... is providing big discounts for all the brand new bamboo ... discounted price (up to 30% off) before the deadline on ...
(Date:8/27/2014)... 27, 2014 IntelliSoft Group, LLC, a ... software, will unveil IntelliCred, IntelliApp and IntelliContract ... Medical Staff Services (NHAMSS) Annual Conference on September 16, ... Bedford, NH. , Notable improvements available in IntelliSoft’s ... , Contract Linking: A new Contract Connection Tab ...
(Date:8/27/2014)... August 27, 2014 President Obama is ... immigration. A White House initiative that supplies green ... undocumented immigrants would also open a pathway to Social ... , Access to work authorization would add new ... the program is the target of proposals to cut ...
(Date:8/27/2014)... August 27, 2014 Janice Holly Booth ... necessity when no-one would join her on an adventure outing ... an extreme sport involving ropes, harnesses and rappelling into mysterious, ... with solo travel but definitely not my last,” she says. ... that pushed me to the edge, and experienced first-hand the ...
(Date:8/27/2014)... 2014 *To find out more about this ... Clinical Research on the web ( http://www.achieveclinical.com ) or contact ... There is no cost to participate ... Compensation may be provided for time and travel ... that there are at least 5 million Americans living with ...
Breaking Medicine News(10 mins):Health News:Brand New Bamboo Plywoods Now Offered At BambooIndustry.com 2Health News:IntelliSoft Group to Unveil Version 14.2 of IntelliCred, IntelliApp and IntelliContract at the New Hampshire Association of Medical Staff Services Annual Conference 2Health News:The Senior Citizens League (TSCL) Warns: White House Action On Immigration Could Give Social Security To Known Illegals 2Health News:Best-selling Author Janice Holly Booth Offers Tips to Navigating Fear and Living a Fuller Life 2Health News:Achieve Clinical Research Is Looking for Qualified Individuals Who Are Interested in Participating in a Fibromyalgia Clinical Trial in Birmingham, Alabama 2Health News:Achieve Clinical Research Is Looking for Qualified Individuals Who Are Interested in Participating in a Fibromyalgia Clinical Trial in Birmingham, Alabama 3
(Date:8/26/2014)... Aug. 26, 2014  When it comes to diabetes supplies, ... relevance. But Timesulin happens to answer a real medical ... pen on the market, Timesulin shows how long it,s ... preventing from missed or double insulin doses. Very easy ... back on the insulin pen after an injection. There ...
(Date:8/26/2014)... 26, 2014 Acelleron Medical Products of ... ., is expanding.  Acelleron, a home medical equipment provider, ... division, Acelleron Maternal Health & Wellness (MHW), to offer a ... full range of resources for pregnant women and families. ... director of maternal wellness. Vecchi, the former owner of Maternal ...
(Date:8/26/2014)... TUCSON, Ariz. , Aug. 26, 2014 ... Artificial Heart, is high on the Inc. 5000 named ... "SynCardia manufactures the world,s only FDA, Health Canada and ... a bridge to a matching donor heart transplant," says ... "It has become the standard of care for patients ...
Breaking Medicine Technology:Montméd obtains reimbursement of Timesulin, the smart insulin pen timer cap, by major insurance companies in Canada 2Suzanne Vecchi Named Director of Newly Acquired Acelleron Maternal Health & Wellness 2Inc. Magazine Ranks SynCardia Systems in Top 3rd in its 2014 Inc. 5000 List 2
Cached News: