HOME >> MEDICINE >> NEWS
Novel drugs help solve Gleevec resistance

s.

Of six patients with advanced accelerated phase of the disease, three had a hematologic response: two were complete, and one patient showed no remaining evidence of leukemia.

One patient demonstrated resistance to BMS-354825, Talpaz reports. Side effects, which included reduced red and white blood cells and platelets, have been well tolerated, he says. Talpaz expects the efficacy of BMS-354825 to increase as more patients are enrolled and tested. "We haven't reached anything close to the maximum tolerated dose, yet we still are showing some remarkable activity," he says. "Very encouraging responses continue to be seen in the new cohort of patients recently enrolled."

Talpaz is co-principal investigator with Charles Sawyers, M.D., professor of medicine at UCLA, of a study that tested 29 patients with early-stage CML who are either resistant to Gleevec or who could not tolerate the drug's side effects. Their study is being presented by Dr. Sawyers in the first presentation at the meeting's plenary session.

The investigators found that in these patients, 73 percent experienced a complete hematologic response "and they have shown that the drug is capable of overcoming Gleevec resistance in the vast majority of cases which resistance is caused by a mutation in the BCR-ABL gene," Talpaz says.

"This is a remarkably high response rate," he says. "Also exciting is the fact that clinical responses matched very well to preclinical testing in animal models. A specific mutation that was resistant to BMS-354825 in the test tube and the animal model was associated with resistance in patients, whereas the other mutations did not induce resistance in the test tube or the patient.

This suggests that we may be able to 'tailor' therapy according to the molecular profile of the disease," Talpaz says. "That means different treatments may be proposed for different patient subsets based on molecular and biochemical screening."


'"/>

Contact: Nancy Jensen
nwjensen@mdanderson.org
713-794-1584
University of Texas M. D. Anderson Cancer Center
5-Dec-2004


Page: 1 2 3 4 5

Related medicine news :

1. Novel therapy tested in mice could chase away cat allergies
2. Novel antibiotic shows promise in shortening treatment duration of tuberculosis
3. Novel p53 gene-based therapy boosts immune system and reduces tumor size
4. Novel imaging technique shows abnormal brain anatomy in children with ADHD
5. Novel drug-antidote strategy provides greater control of drug action
6. Novel imaging technique shows lymph nodes, metastases in breast cancer without surgery
7. Novel delivery method for nutrients wins Kaye Innovation Award for Hebrew university students
8. Novel vitamin discovery offers clues for cancer chemotherapy and lipid disorders
9. Novel findings about neovessel formation
10. Novel MRI technique provides clear images of blood flow
11. Novelty-seeking teens may be more easily influenced by tobacco advertisements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/15/2020)... Ill. (PRWEB) , ... February 14, 2020 , ... ... color-coded cleaning products, partnered with Baptist Easley Hospital , a member of ... safe patient environments. With PCPLUS, the world-class hospital was able to cut its ...
(Date:2/15/2020)... (PRWEB) , ... February 14, 2020 , ... It all ... Martinez (Creator), started drawing these heart-shaped characters and knew she was on to something ... to support children navigate through any life challenge including a health condition or illness, ...
(Date:2/14/2020)... ... February 14, 2020 , ... The Dr. Oz Show is an American daytime ... wellness and medical information. As an upcoming guest on the show, New York ... his in-depth medical knowledge. During the segment, Dr. Linkov, a leader and trusted authority ...
(Date:2/14/2020)... ... February 14, 2020 , ... “The ... excess weight, skin texture and discoloration, and lines and wrinkles. And the treatments ... is offering some great specials in February specifically to address the areas our ...
(Date:2/13/2020)... ... February 13, 2020 , ... Charles Seal-Villafranca, DHA(c), MSHA, ... Phoenix, AZ announced today his re-election as the President of the Arizona State ... (NCIA). , As President of the State Board, Villafranca acts as the ...
Breaking Medicine News(10 mins):
(Date:2/15/2020)... ... ... Clean the World, a leader in global health dedicated to WASH (water, ... hospitality partners has enabled them to increase customer support capacity by 600%, leading to ... World to produce 5.8 million bars in 2019 – 2 million additional bars, up ...
(Date:2/14/2020)... ... February 14, 2020 , ... American International College ... fall semester 2020, the first of its kind in this region. , ... in the cannabis industry and will provide students with an understanding of the ...
(Date:2/14/2020)... ... ... Gramercy Dental Center , located at 118 East 19th Street in New ... of dental services in one convenient location. Dr. Mark Don brings over four decades ... restorative dentist Dr. Patricia Sciortino. Together, they are equipped to offer a broad range ...
Breaking Medicine Technology:
Cached News: