HOME >> MEDICINE >> NEWS
Novel drugs help solve Gleevec resistance

e."

BMS-354825 has a dual mechanism of action, which gives it a 100-fold greater potency to inhibit BCR-ABL, based on preclinical tests that compared it to Gleevec, Talpaz says. Such experiments also have shown that it can treat 14 of 15 mutations that arise in Gleevec-resistant tumors, he says. Giles adds that this appears to be similar to the activity profile of AMN107.

Like AMN107, BMS-354825 binds to the active form of Bcr-Abl. It is less specific than AMN107, however, and therefore has a broader spectrum of action because it inhibits a family of tyrosine kinases known as Src, Talpaz says.

"This is an engineered drug so we know exactly how it works, but we cannot say at this point whether there are clinically meaningful differences between BMS-354825 and AMN107," he says. "Many more studies are needed to see how these drugs will perform."

The bottom line, says Giles, is that "rational drug design is a reality and effective targeted therapies will rapidly increase in number, which means that options for patients are expanding," he says. "Prognosis of diseases that were, until very recently, rapidly fatal is getting better at an unprecedented rate. Science works."


'"/>

Contact: Nancy Jensen
nwjensen@mdanderson.org
713-794-1584
University of Texas M. D. Anderson Cancer Center
5-Dec-2004


Page: 1 2 3 4 5

Related medicine news :

1. Novel therapy tested in mice could chase away cat allergies
2. Novel antibiotic shows promise in shortening treatment duration of tuberculosis
3. Novel p53 gene-based therapy boosts immune system and reduces tumor size
4. Novel imaging technique shows abnormal brain anatomy in children with ADHD
5. Novel drug-antidote strategy provides greater control of drug action
6. Novel imaging technique shows lymph nodes, metastases in breast cancer without surgery
7. Novel delivery method for nutrients wins Kaye Innovation Award for Hebrew university students
8. Novel vitamin discovery offers clues for cancer chemotherapy and lipid disorders
9. Novel findings about neovessel formation
10. Novel MRI technique provides clear images of blood flow
11. Novelty-seeking teens may be more easily influenced by tobacco advertisements

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/17/2019)... MATEO, Calif. (PRWEB) , ... September 17, 2019 ... ... the CE Mark for Europe and the 21st Century Cures Act in the ... spine surgery, radiology, and pain management. Using images from existing MRI equipment ...
(Date:9/17/2019)... ... 17, 2019 , ... Dr. Jacqueline Subka offers patients with ... A minimally invasive approach to gum surgery, laser dentistry is nearly painless and ... gentle and effective because it simply uses laser light to evaporate diseased tissue. ...
(Date:9/17/2019)... CITY, Mo. (PRWEB) , ... September 17, 2019 ... ... health providers to join the largest accountable care organization (ACO) in the country, ... to join this groundbreaking collaboration to improve care quality and increase cost efficiency. ...
(Date:9/17/2019)... ... September 17, 2019 , ... Lubin Austermuehle, P.C. ... Gather for GRIN2B will be held at Found Kitchen and Social House in ... help fund research on GRIN2B-Related Neurodevelopmental Disorder, a rare condition that results from changes ...
(Date:9/17/2019)... (PRWEB) , ... September 17, 2019 , ... ... the availability of the newly updated International Audit Protocol Consortium (IAPC) EHS audit ... audit protocols to understand the scope of their EHS regulatory obligations and rapidly ...
Breaking Medicine News(10 mins):
(Date:9/18/2019)... ... , ... Henry Ford e-Home Care has announced a significant ... Care program. Achieving monthly readmission rates as low as 7%, Henry Ford e-Home ... of 2019 by 45% compared with the prior six months of 2018. Utilizing ...
(Date:9/18/2019)... ... ... U.S. Dermatology Partners was a proud sponsor of the 9th ... The event took place at Lake Ray Hubbard in Rockwall. Over 340 swimmers raised ... money raised helps fund phase 1 clinical trials for cancer research for difficult to ...
(Date:9/17/2019)... ... 2019 , ... Scientists writing in a 2017 issue of ... progressive destruction of joint cartilage in osteoarthritis are “on the close horizon.” ... orthopedic surgeon Alejandro Badia, MD , founder and chief medical officer of ...
Breaking Medicine Technology:
Cached News: