Novel molecule blocks pain receptor system

Discovery May Lead to New Treatments for Pain

Researchers with Banyu Pharmaceutical Co. in Japan have designed a synthetic molecule that can block a molecular pathway, allowing researchers a closer look at what makes some people less sensitive to pain.

This finding will appear in the Dec. 16 issue of the peer-reviewed Journal of Medicinal Chemistry, published by the American Chemical Society, the world's largest scientific society. The article was initially published Nov. 19 on the journal's web site.

Scientists have been studying a nerve receptor called the "opiod receptor-like 1" (ORL-1), which is widely distributed throughout the central nervous system. Like other opiod receptors, ORL-1 was believed to play a key role in pain regulation. However, the natural compounds that activate ORL-1 are different than those that activate the opiod receptors, the researchers say.

In 1995, scientists found a novel hormone, called nociceptin or orphanin FQ, that binds to the ORL-1 receptor. They theorized that blocking the hormone may make a person less sensitive to pain. It has been difficult to test this theory because researchers have lacked an agent to block the hormone-receptor system so its functions could be observed and tested.

Now, the Japanese researchers believe they have found that agent. While there are many different ways to prevent pain, this discovery represents a new avenue for pain research and could be key to development of new and improved drugs to treat pain, says Yoshikazu Iwasawa, Ph.D., research director at Banyu Pharmaceutical Co.

Studies in mice suggest that the ORL-1 receptor and its corresponding hormones may also play important roles in anxiety, learning and memory and other neurological responses. Further understanding of the roles of this hormone-receptor system may lead to drugs not just for pain, but for a variety of neurological disorders, Dr. Iwasawa and hi

Contact: Beverly Hassell
American Chemical Society

Page: 1 2

Related medicine news :

1. Novel therapy tested in mice could chase away cat allergies
2. Novel antibiotic shows promise in shortening treatment duration of tuberculosis
3. Novel p53 gene-based therapy boosts immune system and reduces tumor size
4. Novel drugs help solve Gleevec resistance
5. Novel imaging technique shows abnormal brain anatomy in children with ADHD
6. Novel drug-antidote strategy provides greater control of drug action
7. Novel imaging technique shows lymph nodes, metastases in breast cancer without surgery
8. Novel delivery method for nutrients wins Kaye Innovation Award for Hebrew university students
9. Novel vitamin discovery offers clues for cancer chemotherapy and lipid disorders
10. Novel findings about neovessel formation
11. Novel MRI technique provides clear images of blood flow

Post Your Comments:

(Date:8/31/2020)... ... , ... Just found out your dear friend has cancer? , It’s hard to hear your ... shares their diagnosis. Once the shock wears off, the questions and fears can be overwhelming. ... best ways to help? Words are failing me. I’m scared. I want to DO something. ...
(Date:8/31/2020)... ... August 31, 2020 , ... Colorado State University Global (CSU ... affordable online education – is proud to announce its new master’s degree in ... its kind in the nation, the 60-credit hour program is designed to provide ...
(Date:8/31/2020)... ... August 31, 2020 , ... In an effort to give back to ... 10 percent of each hotel room booked with a special new rate code to ... Indiana (RMHC-CNI) , effective immediately. Donations will be applied to any room type, ...
(Date:8/28/2020)... ... 28, 2020 , ... Ernst & Young LLP (EY US) ... Of The Year® 2020 Florida Award finalist. Now in its 34th year, the ... growth and prosperity as they build and sustain successful businesses that transform our ...
(Date:8/28/2020)... (PRWEB) , ... August 28, 2020 , ... Integrated ... Miami is the first Florida school to deploy its breakthrough Mobile Biodefense Indoor Air ... airborne COVID-19. True North Classical Academy plans to fully reopen equipped with the filtration ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... While coronavirus cases continue to increase across ... and community organizations remain closed. Because about 80% of blood donations are made at ... blood donors and blood drive hosts to ensure blood products are readily available for ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... If you live in New York City ... real estate part makes sense, it’s the law of supply and demand, but are plastic ... has a significant percentage of their patients that make the four-hour trip to have ...
(Date:8/28/2020)... (PRWEB) , ... August 28, 2020 , ... Dr. ... reproductive and endoscopic surgeon and serves as a clinical professor in the Department of ... of the American Laparoscopy Society & Pacific Coast Reproductive Society and is a Clinical ...
Breaking Medicine Technology:
Cached News: