HOME >> MEDICINE >> NEWS
OHSU researchers discover new synapses in brain

For decades, scientists have known that nerve cells in the brain communicate with each other through high-speed contacts called synapses. Now, researchers at Oregon Health Sciences University's Vollum Institute and the University of Oxford have discovered that synapses also are used to communicate with other specialized brain cells called oligodendrocytes. Studying these previously unknown synapses may provide a key for understanding brain function in health and disease. These results appear in the May 11 edition of the journal Nature.

Oligodendrocytes produce myelin, a sheath that surrounds and insulates nerve fibers. This insulation allows nerve fibers to transmit signals at high speed, like the signals from the spinal cord to the leg muscles. The breakdown of myelin around these nerve fibers is believed to be the cause of multiple sclerosis.

Scientists at OHSU, in collaboration with colleagues at the Medical Research Council Unit at Oxford, have found that the oligodendrocytes taking part in this communication are in their immature stage and do not produce myelin. Previous work has shown that glutamate, the chemical used to transmit signals at these synapses, can inhibit the development of these cells into the mature, myelin-producing oligodendrocytes. These newly discovered connections may help answer many remaining questions about how nerve cells regulate myelin formation.

While the research team stresses their basic science finding is years away from providing treatment options for MS patients, they hope to continue building on this work to further understand the beneficial and detrimental nerve communications that take place in the brain.

"It is our hope that continued research will lead to treatments that will stimulate the maturation of these immature oligodendrocytes to allow re-myelination to occur after injury or disease," said Dwight Bergles, Ph.D., a postdoctoral fellow at OHSU and lead author of the paper. "However, it is lik
'"/>

Contact: Jim Newman
newmanj@ohsu.edu
503-494-8231
Oregon Health & Science University
14-May-2000


Page: 1 2

Related medicine news :

1. Indiana University researchers closer to helping hearing-impaired using stem cells
2. Protein that helps skin cancer spread identified by Stanford researchers
3. US life expectancy about to decline, researchers say
4. Gene for age-related macular degeneration discovered by Yale researchers
5. Dartmouth researchers find where musical memories are stored in the brain
6. Columbia researchers receive $3 million to combat genetic killer of infants & toddlers
7. US cancer researchers launch first American-Israeli cancer conference
8. USC dental researchers develop first test for predicting cavities in children
9. Young blood revives aging muscles, Stanford researchers find
10. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
11. Age should not be a factor in determining heart transplantation eligibility, researchers say

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... ... , ... Just found out your dear friend has cancer? , It’s hard to hear your ... shares their diagnosis. Once the shock wears off, the questions and fears can be overwhelming. ... best ways to help? Words are failing me. I’m scared. I want to DO something. ...
(Date:8/31/2020)... ... August 31, 2020 , ... Colorado State University Global (CSU ... affordable online education – is proud to announce its new master’s degree in ... its kind in the nation, the 60-credit hour program is designed to provide ...
(Date:8/31/2020)... ... August 31, 2020 , ... In an effort to give back to ... 10 percent of each hotel room booked with a special new rate code to ... Indiana (RMHC-CNI) , effective immediately. Donations will be applied to any room type, ...
(Date:8/28/2020)... ... 28, 2020 , ... Ernst & Young LLP (EY US) ... Of The Year® 2020 Florida Award finalist. Now in its 34th year, the ... growth and prosperity as they build and sustain successful businesses that transform our ...
(Date:8/28/2020)... (PRWEB) , ... August 28, 2020 , ... Integrated ... Miami is the first Florida school to deploy its breakthrough Mobile Biodefense Indoor Air ... airborne COVID-19. True North Classical Academy plans to fully reopen equipped with the filtration ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... ... September 01, 2020 , ... While coronavirus cases continue to increase across ... and community organizations remain closed. Because about 80% of blood donations are made at ... blood donors and blood drive hosts to ensure blood products are readily available for ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... If you live in New York City ... real estate part makes sense, it’s the law of supply and demand, but are plastic ... has a significant percentage of their patients that make the four-hour trip to have ...
(Date:8/28/2020)... (PRWEB) , ... August 28, 2020 , ... Dr. ... reproductive and endoscopic surgeon and serves as a clinical professor in the Department of ... of the American Laparoscopy Society & Pacific Coast Reproductive Society and is a Clinical ...
Breaking Medicine Technology:
Cached News: