OHSU researchers test medication that targets fever without side effects

September 21, 1999, Portland, Ore.--Each year, cold and flu season closely follows the beginning of the school year. But for some of those who become ill, drugs that fight high fever can also wage a war in other organs in the body. Many common fever reducers like ibuprofen can agitate ulcers, cause upset stomachs and trigger kidney problems in some patients. Now, thanks in part to research at Oregon Health Sciences University, drugs that avoid some of the common side effects of other cold and flu treatments may soon be on the market.

OHSU was one of the sites involved in a multi-state clinical trial of the drug rofecoxib. The testing showed that the drug reduced fever without appearing to affect other important body functions.

To come to this conclusion, patients with fever were solicited through advertisements. Some subjects were given the drug rofecoxib, other patients received ibuprofen and yet another group was given a placebo. Researchers found that all the patients treated with ibuprofen and rofecoxib witnessed a similar drop in fever, despite the fact that the drugs work in very different ways.

Most fever reducers currently on the market target cyclooxygenase (COX) enzymes. Two different forms of the enzyme exist in the body. COX-1 is found in many tissues such as the stomach and the kidneys, where it is involved with day-to-day bodily functions. In contrast, the COX-2 enzyme is not found in most tissues, but surfaces in response to illness. While most medications like ibuprofen affect both forms of the enzyme, rofecoxib specifically targets COX-2. That means COX-1 is left to support normal functions in the body while the new drug inhibits fever production by the COX-2 enzyme. In the past, the interruptions of COX-1 functions have been known to cause kidney and stomach problems for some patients.

"What sets this drug apart from the rest is its ability to focus on the inflammation caused by a virus or bacteria," said Jerris Hedges, M.

Contact: Jim Newman
Oregon Health & Science University

Page: 1 2

Related medicine news :

1. Indiana University researchers closer to helping hearing-impaired using stem cells
2. Protein that helps skin cancer spread identified by Stanford researchers
3. US life expectancy about to decline, researchers say
4. Gene for age-related macular degeneration discovered by Yale researchers
5. Dartmouth researchers find where musical memories are stored in the brain
6. Columbia researchers receive $3 million to combat genetic killer of infants & toddlers
7. US cancer researchers launch first American-Israeli cancer conference
8. USC dental researchers develop first test for predicting cavities in children
9. Young blood revives aging muscles, Stanford researchers find
10. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
11. Age should not be a factor in determining heart transplantation eligibility, researchers say

Post Your Comments:

(Date:7/19/2019)... ... July 19, 2019 , ... Medtelligence , ... Clem as Senior Director of Education Strategy. Clem has extensive experience gained through ... globally with physician experts on comprehensive educational programming, Megan brings a level of ...
(Date:7/18/2019)... ... 2019 , ... LEAD Hospitality Group is preparing to participate in the 36th ... The event is scheduled to take place August 17, 2019 and will kick off ... the King & Queen Buildings. LEAD Hospitality Group will be attending with their running ...
(Date:7/18/2019)... (PRWEB) , ... July 18, 2019 , ... Gateway ... future children, announces a new publication titled, “ Accurate Fetal Sex Determination from Maternal ... Birth. In the study, DNA blood samples were collected from 108 women at an ...
(Date:7/17/2019)... (PRWEB) , ... July 17, 2019 , ... ... to Eastern Kentucky University’s online Family Nurse Practitioner program. The honor is given ... in distance education. , The Catalyst Awards honor institutions from around the ...
(Date:7/17/2019)... ... July 17, 2019 , ... ICD10monitor, an ... ICD-10 coding set, is launching an exclusive educational webcast subscription service featuring 40 ... charge, officials announced this week. , The ICD10monitor webcast portfolio already includes ...
Breaking Medicine News(10 mins):
(Date:7/17/2019)... , ... July 17, 2019 , ... ... DFree ®, the first wearable for urinary incontinence, will be highlighted at ... Stanford, CA, on July 26, 2019. The Innovation Showcase recognizes startups with Japanese ...
(Date:7/17/2019)... ... 17, 2019 , ... Cognition Corporation , a software ... new e-book on developing user needs for life science products. , User ... part of the compliance process and the guiding force for product design. They ...
(Date:7/17/2019)... MINNEAPOLIS (PRWEB) , ... July 17, 2019 , ... ... (TPRI) solutions, today announced an industry expansion into the healthcare sector during the ... healthcare services, staffing, and revenue cycle management join a strong client list ...
Breaking Medicine Technology:
Cached News: