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OHSU researchers test medication that targets fever without side effects

D., M.S., chairman of emergency medicine, OHSU School of Medicine. "Researchers have been studying the reasons behind high temperatures caused by illness for years. However, this is the first drug that can specifically target the pathway causing fever without a noticeable effect on the body's normal housekeeping functions."

A total of 94 patients were involved in the trial. In addition to the testing in Portland, clinical research was conducted in Colorado, Illinois, Kansas, New Jersey, Ohio, Pennsylvania and Texas. Researchers tracked the effect of the medicine over a four-hour period. Following the study, participants received regular checkups to verify that there were no complications caused by the drug.

The Food and Drug Administration is already considering approval of rofecoxib as an anti-inflammatory drug. Past trials show the medication is an effective treatment for arthritis. Approval of rofecoxib as a fever reducer could soon follow.

Research was conducted in conjunction with Merck Research Laboratories in Rahway, New Jersey. The findings are printed in the June edition of Clinical Pharmacology and Therapeutics.


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Contact: Jim Newman
newmanj@ohsu.edu
503-494-8231
Oregon Health & Science University
22-Sep-1999


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