HOME >> MEDICINE >> NEWS
OHSU scientists test medication to treat involuntary weight loss

s to develop and test a medication that would have the same effect. This medication, and others in its class, have excellent oral absorption, which also enhances their appeal as drug candidates.

In this research, the scientists gave both normal mice and mice with a cachexia-like syndrome Neurocrine's orally-administered medication that blocks the MC4 receptor in the brain. In both cases, the animals' appetites increased and their metabolic rates decreased, ultimately resulting in the resumption of normal growth and accumulation of muscle mass. Researchers now hope to conduct clinical trials where both healthy human patients and those suffering from cachexia receive related oral medications to determine the drug's safety and effectiveness.

"We believe the results obtained in this collaborative study with OHSU will provide an important proof-of-principle for Neurocrine's small molecule MC4 receptor antagonist program in animal models relevant for cachexia," said Alan C Foster, Ph.D., Neurocrine Fellow and head of Neurocrine's neuroscience group. Neurocrine is a San Diego-based company that is developing medications related to weight regulation. "We hope to advance an optimized molecule into the first stages of human clinical testing later this year."

"While a lot of attention is paid to the country's obesity epidemic, researchers at OHSU also investigate the other side of weight regulation which is not as well-publicized -- extreme weight loss," said Roger Cone, Ph.D., director of the Center for the Study of Weight Regulation and Associated Disorders. "Cachexia and disorders like it can have extremely serious consequences on patients. This research not only provides hope for these patients, it is also provides another important piece of the puzzle in regards to the brain's control over weight regulation."

The Center for the Study of Weight Regulation and Associated Disorders is a new research institute at Oregon Health & Science
'"/>

Contact: Jim Newman
newmanj@ohsu.edu
503 494-8231
Oregon Health & Science University
29-Mar-2005


Page: 1 2 3

Related medicine news :

1. Earlier use of prostate cancer vaccines urged by Hopkins scientists
2. Tobacco industry pays scientists to challenge secondhand smokes link to infant death risk
3. Schepens scientists regenerate optic nerve for the first time
4. OHSU scientists develop MRI approach to improve breast cancer detection
5. UCLA neuroscientists pinpoint new function for mirror neurons
6. Jefferson scientists uncover potential trigger of diabetic kidney disease
7. Johns Hopkins scientists receive presidential medals
8. UCLA brain scientists crack mystery of how alcohol causes intoxication
9. Wisconsin scientists grow critical nerve cells
10. Jefferson scientists help explain statins effects in Alzheimers disease
11. Jefferson scientists find zinc may help prevent esophageal, oral cancers

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: OHSU scientists test medication treat involuntary weight loss

(Date:3/2/2015)... View, CA (PRWEB) March 02, 2015 ... today that it has officially launched a multivitamin ... Gustafsson, head of product development for BNatrl, said ... through feedback from Olympic and other world-class athletes. ... excited to use this pure whole food multivitamin ...
(Date:3/2/2015)... This year, the National Multiple Sclerosis Society’s annual awareness ... people across the country to unite, raise awareness, ... their best lives. MS Awareness Week is a special week ... the Society’s vision of a world free of MS. ... the central nervous system, interrupts the flow of information within ...
(Date:3/2/2015)... March 02, 2015 Dinner preparation ... thanks to the success of DinnerDork , ... easy and delicious for thousands of busy customers. ... feedback by expanding to offer a total of ... features seasonally appropriate classic recipes and comfort foods; ...
(Date:3/2/2015)... 02, 2015 Four Seasons Resort Maui at ... 25th anniversary this year, having officially opened its doors on ... resort is honoring over 70 employees who started on Day ... amongst the approximately 400 original employees. The celebration will ... Lawn. , This Four Seasons flagship resort, the ...
(Date:3/2/2015)... 2015 A true renaissance man—some might call ... 1960s cult rock band Khazad Doom, has long inspired his ... persevere despite all odds. His motto throughout his life has ... or goal was before him. And that attitude, born amidst ... passed on to a new generation. , As Eadon knows, ...
Breaking Medicine News(10 mins):Health News:Bnatrl Launches Multivitamin Supplement for Runners 2Health News:Every Connection Counts During MS Awareness Week 2Health News:Every Connection Counts During MS Awareness Week 3Health News:Every Connection Counts During MS Awareness Week 4Health News:DinnerDork Announces New Meal Planning Support for the Home Cook 2Health News:DinnerDork Announces New Meal Planning Support for the Home Cook 3Health News:Celebrating Four Seasons Resort Maui’s 25th Anniversary 2Health News:Cult Rock Star’s “Got To Make It” Attitude Inspires New Generations 2Health News:Cult Rock Star’s “Got To Make It” Attitude Inspires New Generations 3
(Date:3/2/2015)... Mount Elizabeth Novena Hospital will soon become ... to treat cancer using the TrueBeam™ STx system ... VAR ).  At a Grand Opening event ... advanced forms of treatment including radiosurgery, a precise method ... a tumor from outside the body, without performing surgery.  ...
(Date:3/2/2015)... the past 15 years, there has been an average of over ... Census Bureau 2012). Of course, not every accident is severe and ... a few where the car occupants can get stuck in their ... button or occupant injury. One may be lucky ... but may still be "lucky" enough to come upon an auto ...
(Date:3/2/2015)...  Delcath Systems, Inc. (NASDAQ: DCTH ), ... oncology with an emphasis on the treatment of primary ... participate in the upcoming 27 th Annual ROTH ... Ritz Carlton Laguna Niguel in Dana Point, ... CRNP, Delcath,s interim President and Chief Executive Officer, will ...
Breaking Medicine Technology:Mount Elizabeth Novena Hospital to Deliver First TrueBeam STx Radiosurgery Treatments in Singapore 2Mount Elizabeth Novena Hospital to Deliver First TrueBeam STx Radiosurgery Treatments in Singapore 3New SuperVizor, an Automobile Escape Tool, Ensures the Safety of Drivers and Passengers on the Road 2Delcath To Present At The 27th Annual Roth Conference 2Delcath To Present At The 27th Annual Roth Conference 3
Cached News: