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Obese individuals may be more susceptible to altitude sickness, researchers report

DALLAS Aug. 19, 2003 Obese individuals traveling to a high-altitude destination should take extra precautions, according to researchers at UT Southwestern Medical Center at Dallas and the Institute for Exercise and Environmental Medicine.

In a study conducted at the institute, a joint venture between UT Southwestern and Presbyterian Hospital of Dallas, researchers report that obesity may be associated with the development of acute mountain sickness (AMS), which is often caused by rapid ascent to altitudes of 2,500 meters, or 8,250 feet, above sea level. Symptoms include headache, nausea and vomiting, fatigue, weakness, dizziness, lightheadedness and sleep disorders.

The researchers' findings, reported in today's issue of Annals of Internal Medicine, also suggest that impaired breathing during sleep may be related to increased levels of AMS in obese individuals.

"Based on the results from our study, obesity may be an important factor in the development of acute mountain sickness," said Dr. Tony G. Babb, assistant professor of internal medicine at UT Southwestern and the study's senior author.

"We recommend that when traveling to high altitudes obese individuals, even those without a history of AMS, take precautions to ensure a slow, gradual ascent," Dr. Babb said. "In addition, these individuals should consider taking the prescription medication acetazolamide, which has been effective in preventing altitude sickness in susceptible travelers."

The study included nine obese men and 10 nonobese men who spent 24 hours in a decompression chamber. The barometric pressure was held steady at the equivalent to an altitude of 3,658 meters, or about 12,000 feet. Study participants completed an AMS self-report questionnaire that measured symptoms associated with altitude sickness at sea level and during decompression. Symptoms were measured at six hours, 12 hours and 24 hours.

Seventy-eight percent of obese study participants se
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Contact: Amy Shields
amy.shields@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
19-Aug-2003


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