Optical glucose sensor holds promise for diabetics and intensive care patients

d us through the early stages when we were stumbling around and trying to figure out how to do this," Wessling said.

Singaram's group is now collaborating with a local company, Glumetrics LLC, which is developing a line of products based on the optical glucose sensor. Glumetrics was founded by Singaram's colleague Todd Wipke, a professor of chemistry and biochemistry at UCSC, but not a member of Singaram's research team.

"I thought it was a good project and wanted to see if I could put together a group of investors and a management team to take it on and develop the applications," said Wipke, who chairs the Board of Directors of Glumetrics.

The optical glucose sensor consists of a fluorescent chemical complex immobilized in a "thin-film hydrogel." The hydrogel, a biocompatible polymer similar to that used to make soft contact lenses, is permeable to glucose. The sensing system has two components: a fluorescent dye and a "quencher" that is responsive to glucose. In the absence of glucose, the quencher binds to the dye and prevents fluorescence, while the interaction of glucose with the quencher leads to dissociation of the complex and an increase in fluorescence.

Singaram's team tested the sensor by mounting it in a flow cell and circulating a solution with varying concentrations of glucose through the cell. The results showed that the system functions as a continuous glucose monitor capable of operating under physiological conditions. The sensor shows outstanding glucose response over the full range of glucose levels that might occur in a diabetic, Singaram said.

"This is the first system to show reversible optical sensing of glucose with a thin-film hydrogel. We tested the sensor under conditions that are as close as possible to the physiological conditions under which a continuous glucose monitor would have to operate," he said.

In addition to Singaram and Wessling, the authors of the recent paper include Jeff Suri

Contact: Tim Stephens
University of California - Santa Cruz

Page: 1 2 3 4 5

Related medicine news :

1. Optical technique identifies vulnerable plaques in cardiac patients
2. Optical technique studies brain activity without surgery on skull
3. Optical Technology Projects Images Directly Into The Eye
4. Elevated glucose levels and diabetes are associated with increased risk for cancer
5. Fatty acid pathway, glucose combine to produce triacetic acid lactone
6. On the horizon of glucose monitoring: A review
7. New biological sensors for detecting blood glucose developed by Hebrew University, U.S. Scientists
8. Detection of glucose intolerance after heart attack
9. Detection of glucose intolerance after heart attack could identify risk of cardiovascular disease
10. Many patients with diabetes do not follow advice to monitor blood glucose
11. Carbon nanotubes yield a new class of biological sensors

Post Your Comments:

(Date:10/13/2017)... ... October 13, 2017 , ... As health professionals work ... as “patient engagement.” The patient is doing more than filling out a survey; in ... “There is an increasing emphasis in health care and research on the importance of ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... PurhealthRX ... CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil will ... and providing a CBD form that can be easily incorporated into liquid products, while ...
(Date:10/13/2017)... ... October 13, 2017 , ... Many families have long-term insurance that covers care ... have a waiver for care if the client has a cognitive impairment diagnosis. ... for care, is often waived, so the benefits from their insurance start immediately,” said ...
(Date:10/13/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has released a ... books in the Holy Scriptures, Revelation. The Book of Revelation paints a picture of ... have tossed it off as mere rubbish, but Yisrayl Hawkins says that is because ...
(Date:10/13/2017)... ... ... On The Brink”: the Christian history of the United States and the loss of ... William Nowers. Captain Nowers and his wife, Millie, have six children, ten grandchildren, ... Navy. Following his career as a naval aviator and carrier pilot, he spent ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today ... Las Piedras, Puerto Rico , where ... Following a comprehensive ... minor structural damage, temporary loss of power and minimal ... completed, manufacturing operations have resumed, and the company expects ...
(Date:10/7/2017)... --  Provista, a proven leader in the supply ... power, today announced a new resource area on Provistaco.com ... is the online home for case studies, articles on ... releases, slideshows and events. ... at their fingertips, viewers can also watch short videos ...
(Date:10/4/2017)... 2017  According to the Centers for Disease Control and Prevention (CDC), ... PhysicianOne Urgent Care is helping communities across Massachusetts , ... by offering no-cost* flu shots through the end of the month. ... insurance regulations. ... get a flu shot is by the end of October, according to ...
Breaking Medicine Technology:
Cached News: