Oregon State chemist wins national award for synthesizing molecules in nature

James D. White of Corvallis, Ore., will be honored Sept. 9 by the world's largest scientific society for discovering ways to make complex molecules in the laboratory, often those that show promise as drugs such as anti-cancer agents. He will receive the 2003 Arthur C. Cope Senior Scholar Award from the American Chemical Society at its national meeting in New York.

"My whole approach to becoming a synthetic organic chemist came from making things with my hands," said White, a chemistry professor at Oregon State University. As a boy growing up in England, he explained, "I was always into fiddling with things I was a model airplane buff as a teenager, for example."

He describes his work now as "essentially molecule-building, putting pieces together with elegance and skill." In a career that has spanned more than four decades, he and his research team have achieved that goal a remarkable 45 times, recreating natural products made by plants, microorganisms or animals.

Researchers often look to synthetic methods because harvesting a compound directly from nature especially in quantity, as in the case of a successful drug candidate may be too expensive or its source too scarce.

One of White's projects in recent years has focused on epothilone, a compound derived from bacteria that shows promise as a treatment for cancer. Early clinical studies show it attacks the same cell processes as taxol, itself a natural product first found in the Pacific yew tree.

Epothilone "caught my eye in the mid-1990s," he said, "and it looked like we could plan its synthesis with little problem. And we did, with a unique and successful 25-step synthesis."

A U.S. pharmaceutical company has since expressed interest in using White's synthesis to develop the compound, and indeed epothilone may one day replace taxol in treating cancer: "The molecule certainly can be synthesized in sufficient quantity, and completely in the lab," unlike taxol, he sa

Contact: Sharon Worthy
American Chemical Society

Page: 1 2

Related medicine news :

1. Micro nano breakthrough conference planned for Portland, Oregon
2. OHSU researcher co-authors National State-By-State Report Card on women and smoking; Oregon flunks
3. Oregon Health Sciences University Researchers track long-term results of chemotherapy assisted by blood-brain barrier disruption
4. Oregon Health Sciences University researchers study benefits of treatments offered within hours of a stroke
5. Lower death rate in Oregon hospitals linked to better care
6. One of first bone marrow transplants for juvenile rheumatoid arthritis in the United States is approved for Oregon girl
7. 12-year-old Oregon girl is first child to receive new bone growth material in her skull
8. Oregon Health Sciences University, Portland, Oregon receives $6.5 million to fund studies on health of adolescents and firefighters
9. Oregons Terminally Ill Patients More Likely to Have End-Of-Life Choices Respected, Study Finds
10. Oregon Health Sciences University Researcher Presents Results Of Clinical Trials Of Possible Stroke-Fighting Drug
11. International breast cancer prevention study launches in the United States and Canada

Post Your Comments:

(Date:3/30/2021)... , ... March 29, 2021 , ... ... the 21st Century , A Virtual Workshop Presented by WCG FDAnews and Cerulean ... 4:30 pm EDT, https://wcg.swoogo.com/modern-sop-and-quality-systems , Are one’s SOPs written for the ...
(Date:3/30/2021)... ... March 29, 2021 , ... According to data released ... reproductive age (13-44) in need of publicly funded contraception live in counties impacted by ... Colorado’s 64 counties have lost some of their Title X resources. , The ...
(Date:3/30/2021)... ... March 29, 2021 , ... Health Literacy Innovations (HLI), a ... confusion due to low health literacy today announces a new partnership with the ... work with ACAP’s member Safety Net Health Plans, those that provide comprehensive health ...
(Date:3/30/2021)... ... ... Dr. Colin Campbell is proud to announce the 1 year anniversary in their new state ... internal medicine and is a primary care specialist who has been practicing for 23 years. ... keep South Jersey healthy one patient at a time. , “Over the past year, Dr. ...
(Date:3/30/2021)... ... March 30, 2021 , ... The COVID-19 ... and survivors; their families; and their caregivers. Crossroads4Hope is addressing the needs of ... emotional support system, MyGo2Support, which meets needs of people impacted by cancer, no ...
Breaking Medicine News(10 mins):
(Date:3/30/2021)... ... March 29, 2021 , ... The University of Texas Health Science Center ... San Antonio Multispecialty and Research Hospital, a destination center for research and treatment of ... In a nod to the COVID-19 pandemic, the ceremony was held virtually. , William ...
(Date:3/30/2021)... ... March 29, 2021 , ... Iora Health ... primary care, has partnered with Devoted Health , one of the fastest-growing ... across Maricopa County and provides seniors with the highest-quality care and experience possible, ...
(Date:3/30/2021)... CITY (PRWEB) , ... March 29, 2021 , ... ... has joined the Vaccine Credential Initiative (VCI), a group bringing together leading health ... record of vaccination status, based on open, interoperable standards. By joining the VCI ...
Breaking Medicine Technology:
Cached News: