Oregon State chemist wins national award for synthesizing molecules in nature

James D. White of Corvallis, Ore., will be honored Sept. 9 by the world's largest scientific society for discovering ways to make complex molecules in the laboratory, often those that show promise as drugs such as anti-cancer agents. He will receive the 2003 Arthur C. Cope Senior Scholar Award from the American Chemical Society at its national meeting in New York.

"My whole approach to becoming a synthetic organic chemist came from making things with my hands," said White, a chemistry professor at Oregon State University. As a boy growing up in England, he explained, "I was always into fiddling with things I was a model airplane buff as a teenager, for example."

He describes his work now as "essentially molecule-building, putting pieces together with elegance and skill." In a career that has spanned more than four decades, he and his research team have achieved that goal a remarkable 45 times, recreating natural products made by plants, microorganisms or animals.

Researchers often look to synthetic methods because harvesting a compound directly from nature especially in quantity, as in the case of a successful drug candidate may be too expensive or its source too scarce.

One of White's projects in recent years has focused on epothilone, a compound derived from bacteria that shows promise as a treatment for cancer. Early clinical studies show it attacks the same cell processes as taxol, itself a natural product first found in the Pacific yew tree.

Epothilone "caught my eye in the mid-1990s," he said, "and it looked like we could plan its synthesis with little problem. And we did, with a unique and successful 25-step synthesis."

A U.S. pharmaceutical company has since expressed interest in using White's synthesis to develop the compound, and indeed epothilone may one day replace taxol in treating cancer: "The molecule certainly can be synthesized in sufficient quantity, and completely in the lab," unlike taxol, he sa

Contact: Sharon Worthy
American Chemical Society

Page: 1 2

Related medicine news :

1. Micro nano breakthrough conference planned for Portland, Oregon
2. OHSU researcher co-authors National State-By-State Report Card on women and smoking; Oregon flunks
3. Oregon Health Sciences University Researchers track long-term results of chemotherapy assisted by blood-brain barrier disruption
4. Oregon Health Sciences University researchers study benefits of treatments offered within hours of a stroke
5. Lower death rate in Oregon hospitals linked to better care
6. One of first bone marrow transplants for juvenile rheumatoid arthritis in the United States is approved for Oregon girl
7. 12-year-old Oregon girl is first child to receive new bone growth material in her skull
8. Oregon Health Sciences University, Portland, Oregon receives $6.5 million to fund studies on health of adolescents and firefighters
9. Oregons Terminally Ill Patients More Likely to Have End-Of-Life Choices Respected, Study Finds
10. Oregon Health Sciences University Researcher Presents Results Of Clinical Trials Of Possible Stroke-Fighting Drug
11. International breast cancer prevention study launches in the United States and Canada

Post Your Comments:

(Date:8/31/2020)... ... August 31, 2020 , ... Bonde Innovations, LLC, a ... advanced heart failure, today announced that the company has been awarded a Phase ... the National Heart, Lung, and Blood Institute of the National Institutes of Health ...
(Date:8/28/2020)... ... August 28, 2020 , ... ... Craig Mandeville was named an Entrepreneur Of The Year® 2020 Florida Award finalist. ... business leaders whose ambitions deliver innovation, growth and prosperity as they build and ...
(Date:8/28/2020)... (PRWEB) , ... August 28, 2020 , ... ... a one-year subscription to a customized Lighthouse Health & Wellness mobile app and ... of this project. Motorola Solutions Foundation awards grants each year to organizations, such ...
(Date:8/28/2020)... MIAMI (PRWEB) , ... August 28, 2020 , ... ... in Miami is the first Florida school to deploy its breakthrough Mobile Biodefense Indoor ... destroy airborne COVID-19. True North Classical Academy plans to fully reopen equipped with the ...
(Date:8/28/2020)... ... 2020 , ... A July 27 article on ... an increased risk of developing severe COVID-19 symptoms. The article does not suggest ... same organ systems that the coronavirus attacks are already suffering from the adverse ...
Breaking Medicine News(10 mins):
(Date:8/31/2020)... ... August 31, 2020 , ... Cloudticity ... has named Cloudticity a Gold winner in the 15th Annual 2020 Network PG’s ... o ns from Network Products Guide honoring achievements of world’s best ...
(Date:8/27/2020)... Texas (PRWEB) , ... August 27, 2020 , ... Austin ... Texas – is pleased to announce Dr. David Szalay, DDS, MD, has joined the ... treat patients in the new Pflugerville office, which is scheduled to open this fall. ...
(Date:8/27/2020)... ... August 27, 2020 , ... The GHT Companies ... its fundraising initiative for Feeding San Diego with a press conference at ... Companies presents the final check of $5,000.00+ representing an overall donation result exceeding $30,000 ...
Breaking Medicine Technology:
Cached News: