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Other highlights in the August 20 issue of JNCI

Study May Explain Association Between Obesity and Breast Cancer Risk

Obesity has been associated with an increased risk of breast cancer among postmenopausal women, but the mechanism for this association has not been established. A new study suggests that the risk increase may result from an associated increase in the production of estrogens. Timothy J. Key, D.Phil., of the University of Oxford, and his colleagues from the Endogenous Hormones and Breast Cancer Collaborative Group analyzed data from eight prospective studies of postmenopausal women and found that breast cancer risk increased with increasing body mass index (a measure of height with respect to weight). However, after adjusting for estrogens, the risk was substantially reduced, suggesting that the increase in breast cancer risk with increasing body mass index is largely the result of the associated increase in estrogens.

Contact: Peter Flynn or Steve Palmer, Cancer Research U.K., 44-20-7061-8300; Karen Carter Mallet, Fox Chase Cancer Center, 215-728- 2700, k_carter@fccc.edu.

Heavier Men May Have a Lower Risk of Prostate Cancer

Under certain conditions, heavier men have a lower risk of developing prostate cancer than men who weigh less, according to a new study. Edward Giovannucci, M.D., Sc.D., of the Harvard School of Public Health in Boston, and his colleagues examined 2,896 cases of prostate cancer in men participating in the Health Professionals Follow-Up Study. They found that men with a higher body mass index had a lower risk of prostate cancer than men with a lower body mass index, but only if they were younger than age 60 or had a family history of prostate cancer. Such an association was not seen in men with sporadic prostate cancers.

Contact: Kevin Myron, Harvard School of Public Health, 617-432-3952, kmyron@hsph.harvard.edu.

Heavier, Taller Women M
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Contact: Linda Wang
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
19-Aug-2003


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