Other highlights of the M...( ead to new therapies for ovarian cancer...)

Other highlights of the May 21 JNCI

ead to new therapies for ovarian cancer, the authors say.

Contact: Jennifer O'Brien, University of California, San Francisco, 415-476-2557 jobrien@pubaff.ucsf.edu.

Discovery May Lead to Less Toxic Cancer Immunotherapy: Researchers have identified a region of cytokine interleukin-2 (IL-2) that may be responsible for causing vasopermeability (i.e., capillary leakage), a side effect that limits use of the drug as a cancer immunotherapy. Alan Epstein, M.D., Ph.D., of the University of Southern California, Keck School of Medicine, and his colleagues synthesized peptide fragments of IL-2, linking them to tumor-targeting antibodies, and examining their ability to induce tumor vascular permeability. One fragment, permeability-enhancing peptide (PEP), had the same vasopermeability activity as IL-2 but lacked cytokine activity, suggesting that the vasopermeability and cytokine activities of IL-2 can be separated. The authors say that the identification of PEP should help researchers find ways to decrease the toxicity of IL-2.

Contact: Jon Weiner, University of Southern California, Keck School of Medicine, 323-442-2830, jonweine@usc.edu.

Cell Growth Inhibitor May be Involved in Melanoma Susceptibility: A new study suggests that the p16 growth inhibitor may play a role in susceptibility to melanoma, the malignant form of skin cancer. Elena V. Sviderskaya, Ph.D., and Dorothy C. Bennett, Ph.D., of the St. George's Hospital Medical School in London, United Kingdom, and their colleagues examined melanocytes (pigment producing cells) taken from two patients with melanoma who had inactivated p16 alleles. They found that these melanocytes proliferated longer than normal melanocytes, suggesting that inactivation of p16 resulted in the impairment of cell growth inhibitory mechanisms. The authors say that their findings may provide some basis f

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Other highlights of the M...( ead to new therapies for ovarian cancer...),Health