HOME >> MEDICINE >> NEWS
Outsmarting cancer - new results from novel enzyme inhibitors

Smart drugs that can break the chain of command between enzymes and the genes involved in cell division and cell death are a new way forward in tackling breast cancer, according to Dr Stephen Johnston, a consultant oncologist from The Royal Marsden Hospital, London, UK.

Presenting results from the worlds first phase II trial of R115777 (Zarnestra) in breast cancer, Dr. Johnston said that among 41 women with advanced cancer who had previously undergone chemotherapy or hormone treatment, four had a partial response from the new drug and in a further six the disease had been stabilised over a prolonged period. Trials are now planned combining R115777 with chemotherapy or hormone therapy, as laboratory studies indicate that the new drug acts synergistically with conventional treatments to boost their effectiveness.

R115777 is one of a novel drug class called farnesyl transferase inhibitors, he told a news briefing at the 3rd European Breast Cancer Conference in Barcelona. Farnesyl transferase is an enzyme that enables a protein called Ras to function and signal correctly within the cell. Ras plays a prominent part in many types of tumours. Although it is rarely directly mutated in breast cancer, Ras often receives signals from growth factors that make it function in an abnormal way, promoting the growth of breast cancer cells. Interrupting the cellular signals by targeting Ras breaks the chain of command between the growth factors and the nucleus of the cell and appears to inhibit the growth of the cancer cells. In addition, several other proteins involved in cell growth and motility may also be farnesylated and so may also be targets for farnesyl transferase inhibitors.

Another key enzyme the 26S proteasome is also in the firing line for smart drugs. Proteasome is a protein complex that modulates the behaviour of cells during the cell cycle. It regulates the levels of key proteins that control the fine balance between normal cell division
'"/>

Contact: Margaret Willson
m.willson@mwcommunications.org.uk
34-93-3644487
Federation of European Cancer Societies
21-Mar-2002


Page: 1 2

Related medicine news :

1. Hormonal treatment improves survival in high-risk prostate cancer patients
2. International breast cancer prevention study launches in the United States and Canada
3. Unexpected benefit seen in treating HER-2 breast cancer with new preoperative drug combo
4. Cultural and social factors influence prostate cancer treatment
5. Primary care office strategies may increase colon cancer screening
6. Benefits of lung cancer screening with CT questioned
7. Three-year cervical cancer screening recommendations may be applicable for certain women with HIV
8. Study finds majority of women willing to accept cervical cancer vaccine for self and children
9. African-American women with endometrial cancer have more aggressive cancer than Caucasian women
10. Employment prospects good for most cancer survivors -- but not all
11. New colorectal cancer screening recommendations for African Americans

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/18/2019)... ... ... She went from learning disabled to honor roll – all because of some ... tests,” performed by Deborah Zelinsky, O.D. , founder of the Mind-Eye Institute in ... of visual awareness, she could only see what was directly in front of her ...
(Date:4/18/2019)... (PRWEB) , ... April 18, 2019 , ... ... releasing its first ever Cannabis Industry Report . The study—which considers consumers’ ... emerging intersections with retail and manufacturing, offering insight into what kinds of products ...
(Date:4/17/2019)... ... ... Kadan Homecare, an award-winning provider of quality, non-medical home care to Atlanta area families ... of Home Care® – Provider of Choice and Employer of Choice Awards from Home ... on client and caregiver satisfaction scores gathered by Home Care Pulse. Kadan is now ...
(Date:4/17/2019)... ... April 17, 2019 , ... Purple ... symptoms. This California-made supplement was designed to lessen the negative effects of ... for purchase via GotPurpleTree.com and Amazon.com . , According to ...
(Date:4/17/2019)... ... April 17, 2019 , ... ... in revolutionary diagnostic technologies. This episode is scheduled to air 3Q 2019 on ... Innovations will focus on Credo Biomedical Pte. Ltd. (Credo Biomedical), a molecular diagnostic ...
Breaking Medicine News(10 mins):
(Date:4/17/2019)... ... April 17, 2019 , ... ... antibodies, kits, and services, today announced that they have formalized partnerships with ... that encourage science and environmental education, arts, and support for the underprivileged ...
(Date:4/17/2019)... ... , ... Clinical trials of new cancer treatments have historically focused on disease ... advances in medical oncology and genomic characterization of tumors, we are now able to ... “basket trials.” This ability has created a paradigm shift in oncology trials. , In ...
(Date:4/17/2019)... Mass. (PRWEB) , ... April ... ... dba MyMedicalShopper , a leading provider of healthcare price transparency solutions, ... based in Massachusetts, are partnering to give consumers more choice and control ...
Breaking Medicine Technology:
Cached News: