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Outstanding efficacy of Crestor (TM) in treating range of patient populations at risk of CVD

London, UK, 25 October 2004. New data presented today from several studies involving more than 5,000 patients provide further evidence of the outstanding efficacy of CRESTORTM (rosuvastatin) in treating key cardiovascular disease (CVD) risk factors in patients with dyslipidaemia and either atherosclerosis, coronary artery disease, type 2 diabetes or the metabolic syndrome.1-5

Results from five studies (DISCOVERY, COMETS, MERCURY I, URANUS, RADAR) presented at the XV International Symposium on Drugs Affecting Lipid Metabolism (DALM) demonstrate that CRESTOR is superior to atorvastatin in improving lipid profiles associated with an increased cardiovascular risk in a number of patient populations with dyslipidaemia.1-5 Results from MERCURY I and DISCOVERY also show that CRESTOR, at the usual start dose of 10mg, enables more patients achieve their US NCEP ATP III and European LDL-C goals, respectively, compared to atorvastatin 10mg, thereby avoiding the need to titrate to higher doses.1,3

In current clinical practice, LDL-C is the most widely recognised target for lowering patients' cardiovascular risk.6,7 Guideline cholesterol goals are an important tool to assist physicians in the management of cardiovascular disease worldwide. Recently revised evidence-based guidelines set a series of targets for LDL-C reduction, which vary according to the overall risk category of the patient; the higher the patient's risk of cardiovascular events, such as heart attack or stroke, the lower the LDL-C goal.7 However, many patients are not achieving their recommended LDL-C treatment guideline goals, suggesting that more intensive management with effective statin therapy is required.8,9 Results from one study of the global DISCOVERY Programme*, involving 911 'high risk' patients with hypercholesterolaemia, demonstrate that more patients achieve the European LDL-C guideline goal of <3mmol
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Contact: Caroline Howe
caroline.howe@shirehealthinternational.com
Shire Health International
25-Oct-2004


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