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Ovarian tissue storage and later transplant shows promise for women infertile from cancer therapy

l be presented as experimental to patients. Only a small part of the ovarian graft can be screened with sensitive techniques for the detection of hosted cancer cells. For some cancers: those that colonise the ovary or that can metastasize into ovary, it will be always difficult to completely exclude the presence of such cells in the graft. To provide an evidence-based approach in future practice, a multicentre trial could be proposed in which girls or young women at intermediate risk of sterility would be randomised between storage of gonadal tissue or non-intervention. Such a prospective study would show which of the two options gives the best chances for obtaining a normal child. Whole-ovary freezing that allows vascular reanastomosis and more in-vitro work, including embryonic stem-cell culture, could provide alternative solutions for patients".


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Contact: Joe Santangelo
j.santangelo@elsevier.com
212-633-3810
Lancet
8-Mar-2004


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