Oxygen therapy may improve vision worsened by diabetes

surements would change by such magnitudes by chance is very small," Campochiaro says.

Once the oxygen therapy was discontinued, vision slowly worsened in some eyes. But in four eyes in which retinal thickness had returned to the normal range while on oxygen, the improvement was maintained even after oxygen was stopped. Since these patients all had previous laser therapy, it is possible that the reduced thickening of the macula achieved by oxygen allowed the laser to exercise a stabilizing effect.

Diabetic macular edema affects up to 10 percent of all patients with diabetes. It is caused when high blood sugar, through a cascade of events, causes damage in normal retinal blood vessels and a decrease in the supply of oxygen and nutrients. Campochiaro and Quan Dong Nguyen, M.D., the principal investigator on the study, hypothesize that the retina, when faced with a decrease in oxygen, releases vascular endothelial growth factor (VEGF) and other substances that cause retinal blood vessels to become leaky and ultimately stimulate the growth of new blood vessels. The leakage of fluid into the macula causes it to become thickened and results in vision loss.

Supplemental oxygen reduces production of VEGF and similar proteins, which in turn reduces the amount of leaking in retinal vessels and lessens the severity of macular edema. The treatment could reduce the thickness of the retina before laser treatment, making the laser more effective and more likely to maintain stability without supplemental oxygen. Alternately, supplemental oxygen could be combined with newer treatments that directly target VEGF. For example, Campochiaro and colleagues also studied an oral drug that blocks receptors for VEGF, called PKC412, which was found to significantly reduce macular edema and improve visual acuity in diabetics. This first demonstration of directly targeting VEGF was reported by the researchers in another study published in the March issue of the jo

Contact: John Lazarou
Johns Hopkins Medical Institutions

Page: 1 2 3

Related medicine news :

1. Oxygen reduces effects of retinal detachment
2. Effects Of 15% Oxygen On Breathing Patterns And Oxygenation In Infants
3. Study shows patch therapy may be as effective as oral medications
4. Novel therapy tested in mice could chase away cat allergies
5. Drug therapy may be comparable to invasive cardiac procedures for elderly patients with heart attack
6. Risk of cardiac death after radiotherapy for breast cancer has declined, study finds
7. Antiretroviral therapy may prevent excess risk of some cancers in people with HIV
8. Bevacizumab combined with chemotherapy prolongs survival for some patients with advanced lung cancer
9. Breakthrough in medical research: New chemotherapy gives hope to brain tumour patients
10. Two years after gene therapy treatments, severe angina patients showed prolonged clinical benefit
11. Combining PET and CT scans leads to more accurate radiation therapy for lung cancer patients

Post Your Comments:

(Date:9/3/2020)... ... September 03, 2020 , ... The growing adoption ... of Fall 2020 Virtual Conference, a two-day virtual event for radiology professionals that ... Beyond" is the follow-up to AuntMinnie.com's successful virtual event in spring 2020, in ...
(Date:9/2/2020)... ... September 02, 2020 , ... RAM Technologies, Inc., the perennial ... and Special Needs plans, is proud to support the 2020 National Conferences on ... is supporting the event as a sponsor and exhibitor and will be showcasing ...
(Date:9/1/2020)... ... 2020 , ... As fall and winter swiftly approach and many businesses cut ... taken this time to expand and grow into a full-fledged natural health clinic over ... will be relaunching its brand new website, expanding its services menu and has recruited ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... Just found out your dear friend has ... heartbreaking when your friend or family member shares their diagnosis. Once the shock wears off, ... say the wrong thing? What are the best ways to help? Words are failing me. ...
(Date:8/31/2020)... ... 2020 , ... Colorado State University Global (CSU Global) – ... education – is proud to announce its new master’s degree in Military ... in the nation, the 60-credit hour program is designed to provide students with ...
Breaking Medicine News(10 mins):
(Date:9/3/2020)... Md. (PRWEB) , ... September 03, 2020 , ... ... National Sickle Cell Awareness Month in September by holding a series of events ... designated by Congress to focus attention on the need for research and treatment ...
(Date:9/3/2020)... ... 2020 , ... Q&J Face Masks announced today that the ... engineering lab, conducted tests on Q&J’s personal face mask that indicated the Q&J ... masks. Q&J face masks have both mechanical filtering and electrostatic filtering which are ...
(Date:9/3/2020)... ... September 03, 2020 , ... Using Analysis of Variance — A Practical ... 2020, 1:30 p.m.-3:00 p.m. EDT, https://www.fdanews.com/anova , How much would it help ... one can’t become one in 90 minutes, one can master a powerful statistical technique ...
Breaking Medicine Technology:
Cached News: