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PET scans show cigarette smoke affects peripheral organs

rch team compared PET scans showing MAO B activity in 12 smokers with scans from 8 nonsmokers. The researchers observed that MAO B activity in the peripheral organs was reduced by one-third to almost one-half in smokers compared with nonsmokers.

The scientists caution that the effects of this finding remain unknown at present. "The consequences of reduced levels of this important enzyme need to be examined in greater detail," explains Dr. Fowler. "Though we do not know the physiological effects of such a reduction in MAO B in peripheral organs, we do know we need the enzyme to break down blood pressure-elevating chemical compounds in certain foods, as well as those that are released by nicotine. Thus, it is possible that lower levels of this enzyme in peripheral organs could have medical consequences."

Previous research by these scientists has shown that the level of MAO B is lower in the brains of smokers.


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Contact: Blair Gately
301-443-6245
NIH/National Institute on Drug Abuse
8-Sep-2003


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