HOME >> MEDICINE >> NEWS
PTH and Alendronate: combining treatments shows no bone density advantage

Combining the bone-building treatment parathyroid hormone (PTH) with alendronate, a drug that slows bone loss, produces no significant improvement in bone mineral density (BMD) beyond that produced by the individual drugs, according to two new studies involving postmenopausal women and men with low BMD.

The two studies, reported in the September 25 issue of the New England Journal of Medicine and supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), one of the National Institutes of Health, both tested BMD in the spine and hip. BMD, a common indicator of bone health, is used to diagnose the bone-weakening disease osteoporosis, detect low bone mass before the disease develops and help predict the risk of future fractures.

Although clinicians had hoped to optimize osteoporosis treatment and increase BMD by combining the two potent medications, the two trials show that PTH alone increases BMD at least as well as or better than combination therapy. Further studies, say some scientists, are needed to see if the optimal effects of these drugs might be achieved by sequential or cyclic therapy. A comparative study of fracture rates would also be needed to assess drug effectiveness.

"Both patients and physicians benefit from knowing how the combination compares to single drug treatment," said NIAMS Director Stephen I. Katz, M.D., Ph.D. "These findings could offer important clinical guidance to those at high risk for fractures and those who treat them."

One study, a randomized, blinded clinical trial involving 238 postmenopausal women with low hip or spine BMD, was carried out at four centers and coordinated at the University of California San Francisco by Dennis Black, M.D., and his colleagues. In the study, featured at the recent meeting of the American Society for Bone and Mineral Research in Minneapolis, the women were given a daily regimen of PTH, alendronate, or a combination of the two. After 12
'"/>

Contact: Ray Fleming
flemingr@mail.nih.gov
301-496-8190
NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases
3-Oct-2003


Page: 1 2

Related medicine news :

1. Timing appears essential to combining antiangiogenesis and radiation therapy
2. Jefferson researchers find combining two types of radiation therapy is better for brain cancer
3. Lung tumor therapies improved by combining CT and PET scans
4. Study shows combining gene therapy and radiation holds promise
5. Scientists declare global warming and human impacts are combining destructive forces on coral reefs
6. Study shows combining antiplatelet drug Abciximab with clot-buster is effective in treating heart-attack patients
7. Chronic pain treatments more effective when taken together, new study shows
8. Research offers hope of new treatments for liver damage
9. Scientist works on innovative treatments for brain tumors
10. Blacks less likely to get expensive, newer heart treatments
11. Two years after gene therapy treatments, severe angina patients showed prolonged clinical benefit

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2020)... ... March 27, 2020 , ... ... Suntuity Group of companies, is mobilizing their drone equipment and training personnel to ... leveraging their DJI Enterprise level Matrice and Agras drones, Suntuity AirWorks is mobilizing ...
(Date:3/28/2020)... YORK (PRWEB) , ... March 27, 2020 , ... ... today announces the launch of this March’s edition of “The Fertility Journey.” This ... the face of fertility, third-party parenting, and maternal health options. , One ...
(Date:3/27/2020)... ... 27, 2020 , ... On March 27th, 2020, Talos Health Solutions , ... their families and caregivers living in the US. This free online conference will be ... 2020, and will focus on asthma symptoms, the different kinds of asthma, treatment options, ...
(Date:3/22/2020)... ... March 21, 2020 , ... In partnership with UC Health, Cincy ... community’s medical professionals and first responders. The title comes from the English translation of ... and its flag. , Proceeds from the sale of the shirt will benefit ...
(Date:3/20/2020)... ... ... My heart goes out to those across our nation and around the world ... through similar circumstances - underlying conditions compounded by a virus – I truly empathize. ... emotions just like many have: fear, anxiety, uncertainty. In contrast, I would like to ...
Breaking Medicine News(10 mins):
(Date:4/1/2020)... ... 2020 , ... Dr. Michele S. Green, board-certified Anti-Aging Expert ... Beauty network. , The Haute Beauty Network, well known for its exclusivity, and ... , Haute Beauty offers a prominent collective of leading doctors nationwide. The invitation-only ...
(Date:4/1/2020)... ... April 01, 2020 , ... ... to sign up today, with the first live-streaming broadcast premiering on April 2. ... feature a host interviewing a variety of animal keepers and veterinary hospital staff ...
(Date:3/30/2020)... ... March 30, 2020 , ... ... solution, TalkWithYourDoc.com . By leveraging technology developed by its wholly owned ... to continue offering revenue-generating healthcare services while serving patients’ needs during the COVID-19 ...
Breaking Medicine Technology:
Cached News: