HOME >> MEDICINE >> NEWS
Pathway may provide target for treating chronic pain

of how and why they become active.

In Nature last year, Zhuo and colleague Ping Li, M.D., a research associate in anesthesiology, reported that they could identify silent synapses by monitoring electrical responses of individual neurons. After these synapses were awakened, they remained active and able to relay painful sensory information to the brain even after the painful stimulus was gone.

In those experiments, the researchers showed that the silent synapses could be activated both by strong pain signals and by messages from a brain region called the rostroventral medulla (RVM), which sends chemical signals to the dorsal horn of the spinal cord. But little was known about what happens inside a nerve cell when a silent synapse is activated.

In the current study, Zhuo and colleagues found that activation of silent synapses involves an interaction between AMPA receptors and a protein called glutamate receptor interacting protein (GRIP).

"One hypothesis is that GRIP binds to the cell at an AMPA receptor site inside of the cell," Zhuo said. "Then, under certain conditions, the receptor moves itself to the synaptic part of the neuron. That movement activates the formerly silent synapse."

Receptors at synapses receive messages from other neurons. AMPA receptors are sensitive to a brain chemical called glutamate.

"AMPA receptors are highly dynamic," said co-investigator Morgan Sheng, M.D., Ph.D., associate professor of neurobiology at Massachusetts General Hospital and Harvard Medical School and assistant investigator with the Howard Hughes Medical Institute. "They can be recruited to and removed from the synapse. It's actually a marvelously simple way to regulate synaptic strength. You silence a synapse by taking away receptors and strengthen it by adding more receptors."

Zhuo compares the process to an overnight courier service. Each evening, many packages come in. But the next morning, those packages go back out, allowing the office to m
'"/>

Contact: Jim Dryden
dryden@medicine.wustl.edu
314-286-0110
Washington University School of Medicine
17-Oct-1999


Page: 1 2 3

Related medicine news :

1. Cell Pathways Aptosyn™ (exisulind) shows continuing long-term prevention of colon polyps in FAP patients
2. Study provides new estimates of the causes of child mortality worldwide
3. Researchers say breast cancer in Africa may provide clues to the disease in African-Americans
4. End AIDS drug waiting lists, HIV care providers tell policymakers
5. Artery clearing system does not provide benefit for patients undergoing PCI
6. Newly identified gene cluster on mouse X chromosome provides insights into fertility
7. University of Washington joins new Autism Treatment Network to provide better medical services
8. Rat whisking may provide insight into debilitating eye disorder
9. Researchers hope monkeys can provide new insights into depression
10. AGI and USGS provide unique tsunami disaster relief
11. New ITN Scholars Program provides junior faculty opportunity to develop clinical trials expertise

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Pathway may provide target for treating chronic pain

(Date:4/18/2014)... 18, 2014) ― A new study in the ... in health-related Google searches reveals a recurring pattern that ... , Investigators from San Diego State University, the ... Campaigns, analyzed "healthy" Google searches (searches that included the ... originating in the U.S. from 2005 to 2012. They ...
(Date:4/17/2014)... identified the first genetic variant specifically associated with ... for around 10-15 per cent of all breast ... the breast cancer sub-type, called invasive lobular carcinoma, ... of this particular kind of breast cancer, which ... published today (Thursday) in the journal PloS ...
(Date:4/17/2014)... the University of California, San Diego School of Medicine ... have suffered a recent major loss are more likely ... , The study is published in this month,s issue ... , Because compassionate behaviors are associated with better health ... insights into ways to improve the outcomes of individuals ...
(Date:4/17/2014)... New Rochelle, NY, April 17, 2014U.S. military personnel ... "blast plus impact" concussive traumatic brain injury (TBI) ... were evacuated for other medical reasons. Differences in ... and depression 6-12 months after injury are reported ... , a peer-reviewed journal from Mary Ann Liebert, ...
(Date:4/17/2014)... 17, 2014 By discovering a new mechanism that ... stroke, researchers at UC Irvine and the Salk Institute ... limit or prevent stroke-induced brain damage. , A complex ... of death and primary reason for disability in the ... stroke and lets blood-borne material into the brain, causing ...
Breaking Medicine News(10 mins):Health News:New research shows people are thinking about their health early in the week 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 3Health News:The ilk of human kindness 2Health News:Long-term effects of battle-related 'blast plus impact' concussive TBI in US military 2Health News:Study IDs new cause of brain bleeding immediately after stroke 2
(Date:1/15/2014)... , January 15, 2014 Shire plc (LSE: ... the Office of Fair Trading (OFT) approval condition to the announced ... (NASDAQ: VPHM).   As a result of the waiver, ... expects to complete the tender offer on January 24, 2014 following ...
(Date:1/15/2014)... LOUISVILLE, Ky. , Jan. 15, 2014  Manufacturers, ... technologies must be able to protect their most ... (Logo: http://photos.prnewswire.com/prnh/20130716/CL46586LOGO ) Because ... Industry, it steadfastly remains one of the most ...
(Date:1/15/2014)... , Jan. 15, 2014 MultiCell Technologies, Inc. ... a U.S. provisional patent application concerning composition of matter, ... achieve targeted tumor cell death.  This ... noncoding double stranded RNA molecules (VSRNAs) which interfere with ...
Breaking Medicine Technology:Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3Intellectual Property Insurance for Medical-related Products and Services 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3
Cached News: