HOME >> MEDICINE >> NEWS
Patients with moderate or severe hand dermatitis responsive to drug therapy

CHICAGO Use of the oral medication alitretinoin was effective in treating moderate or severe hand dermatitis in nearly half of patients previously unresponsive to standard treatment, according to an article in the December issue of The Archives of Dermatology, one of the JAMA/Archives journals.

Hand dermatitis affects six to 11 percent of the population in northern Europe, according to background information in the article. The disease can include redness, scaling, blistering, swelling, itching, and fissures of the skin on the hands. Chronic hand dermatitis (CHaD) has been known to cause psychological distress and temporary or permanent working disability. Although mild cases of CHaD usually respond to topical treatment, more severe cases can be incapacitating in patients who are unresponsive to standard therapy.

Thomas Ruzicka, M.D., of Heinrich-Heine University Hospital Dusseldorf, Germany, and colleagues tested the safety and effectiveness of oral alitretinoin in the treatment of CHaD in patients previously unresponsive to treatment. Three-hundred nineteen patients with moderate or severe CHaD were divided into four treatment groups: to take 10 mg/day, 20 mg/day, or 40 mg/day of alitretinoin, or placebo orally once a day for twelve weeks. Participants were classified as responsive if their dermatitis was clear (no visible dermatitis) or almost clear (minimal redness and/or scaling).

Twenty-nine to 39 percent of patients receiving 10 mg/day of alitretinoin were responsive, 34 to 41 percent in the 20 mg/day group were responsive, and 43 to 53 percent of those in the 40 mg/day group were responsive to treatment, compared to 12 to 27 percent of patients in the placebo group who were responsive. Headache was the most frequent adverse effect leading to withdrawal from the study in participants who received alitretinoin.

"In this study, oral alitretinoin induced clinically significant responses in a high percentage of patients with m
'"/>

Contact: Thomas Ruzicka, M.D.
ruzicka@uni-duesseldorf.de
JAMA and Archives Journals
20-Dec-2004


Page: 1 2

Related medicine news :

1. Patients newly diagnosed with HIV are more likely to enter outpatient care with case management
2. Patients with cancer have highly increased risk for blood clots
3. Patients with previous heart attacks may not benefit from pacemaker implant
4. Patients with cancer detected on screening mammography undergo less toxic treatment
5. Patients with abdominal trauma at risk for intra-abdominal infections following surgery
6. Patients who are intubated prior to hospital arrival fare worse find Pitt researchers
7. Patients undergoing weight loss surgery have high rates of H pylori bacteria
8. Patients with chronic sinus do not necessarily develop antibiotic resistance
9. Plastic surgeons honor Patients of Courage overcoming difficult obstacles, inspiring others
10. Patients with severe depression improve using guidelines developed by UT Southwestern researchers
11. Patients not sticking to cholesterol drugs -- and the higher their co-pay, the lower their use

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/8/2019)... Texas (PRWEB) , ... October 08, 2019 , ... ... intelligence company, appointed distinguished innovator, Dr. Jerry Henderson as Chief Medical Officer. Dr. ... data registries analytics platforms. , Dr. Henderson previously served as Chair of ...
(Date:10/8/2019)... (PRWEB) , ... October 08, 2019 , ... ... selected CardioWise, Inc. a Digital Health Awards 1st Round (Top Ten) ... Digital Health Awards was to select companies that promote faster, better, more cost-effective ...
(Date:10/8/2019)... ... October 08, 2019 , ... Join Director of ... and Infectious Disease Physician at Loyola University Medical Center, Fritzie Albarillo, MD, in ... The speakers will discuss the benefits and challenges with implementing a syndromic multiplex ...
(Date:10/8/2019)... (PRWEB) , ... October 08, 2019 , ... ... released the findings of a new study showing that Care4U™ 2’-FL, a DuPont ... to galacto-oligosaccharides (GOS) and lactose. The effects elicited to microbiota and metabolite composition ...
(Date:10/8/2019)... ... October 08, 2019 , ... Smile Haus in West Hills, California is excited ... Dr. Mustapha Hotait founded Smile Haus, one of his first priorities was to launch ... appointments, learn about the practice, and complete new patient forms online. , According to ...
Breaking Medicine News(10 mins):
(Date:10/8/2019)... ... 2019 , ... “When Seconds Count: Reports From an Emergency Medical Helicopter Pilot”: ... world through telling the real stories of the EMS flight crew. “When Seconds Count: ... A. Humphrey, an EMS helicopter pilot. He has been a pilot in the HEMS ...
(Date:10/8/2019)... ... , ... Dr. Ryan McNally, ND, MS, PA and Dr. Shashita Inamdar, MD, ... conference. Their presentation titled Advances in Integrative Neuropsychiatry and Functional Mental Health, will evaluate ... promote brain health, and reduce the debilitating symptoms of a range of neuropsychiatric disorders. ...
(Date:10/8/2019)... ... October 08, 2019 , ... Dr. ... raise awareness of their advanced dental and medical training to offer medically ... welcome patients with heart conditions, diabetes, and other systemic concerns for dental implants ...
Breaking Medicine Technology:
Cached News: