HOME >> MEDICINE >> NEWS
Patients with moderate or severe hand dermatitis responsive to drug therapy

CHICAGO Use of the oral medication alitretinoin was effective in treating moderate or severe hand dermatitis in nearly half of patients previously unresponsive to standard treatment, according to an article in the December issue of The Archives of Dermatology, one of the JAMA/Archives journals.

Hand dermatitis affects six to 11 percent of the population in northern Europe, according to background information in the article. The disease can include redness, scaling, blistering, swelling, itching, and fissures of the skin on the hands. Chronic hand dermatitis (CHaD) has been known to cause psychological distress and temporary or permanent working disability. Although mild cases of CHaD usually respond to topical treatment, more severe cases can be incapacitating in patients who are unresponsive to standard therapy.

Thomas Ruzicka, M.D., of Heinrich-Heine University Hospital Dusseldorf, Germany, and colleagues tested the safety and effectiveness of oral alitretinoin in the treatment of CHaD in patients previously unresponsive to treatment. Three-hundred nineteen patients with moderate or severe CHaD were divided into four treatment groups: to take 10 mg/day, 20 mg/day, or 40 mg/day of alitretinoin, or placebo orally once a day for twelve weeks. Participants were classified as responsive if their dermatitis was clear (no visible dermatitis) or almost clear (minimal redness and/or scaling).

Twenty-nine to 39 percent of patients receiving 10 mg/day of alitretinoin were responsive, 34 to 41 percent in the 20 mg/day group were responsive, and 43 to 53 percent of those in the 40 mg/day group were responsive to treatment, compared to 12 to 27 percent of patients in the placebo group who were responsive. Headache was the most frequent adverse effect leading to withdrawal from the study in participants who received alitretinoin.

"In this study, oral alitretinoin induced clinically significant responses in a high percentage of patients with m
'"/>

Contact: Thomas Ruzicka, M.D.
ruzicka@uni-duesseldorf.de
JAMA and Archives Journals
20-Dec-2004


Page: 1 2

Related medicine news :

1. Patients newly diagnosed with HIV are more likely to enter outpatient care with case management
2. Patients with cancer have highly increased risk for blood clots
3. Patients with previous heart attacks may not benefit from pacemaker implant
4. Patients with cancer detected on screening mammography undergo less toxic treatment
5. Patients with abdominal trauma at risk for intra-abdominal infections following surgery
6. Patients who are intubated prior to hospital arrival fare worse find Pitt researchers
7. Patients undergoing weight loss surgery have high rates of H pylori bacteria
8. Patients with chronic sinus do not necessarily develop antibiotic resistance
9. Plastic surgeons honor Patients of Courage overcoming difficult obstacles, inspiring others
10. Patients with severe depression improve using guidelines developed by UT Southwestern researchers
11. Patients not sticking to cholesterol drugs -- and the higher their co-pay, the lower their use

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/10/2018)... LOMA LINDA, Calif. (PRWEB) , ... December 10, 2018 , ... ... study assessing all 18 major freight railyards in California and found a link with ... published in Preventive Medicine Reports. , This large-scale railyard study is ...
(Date:12/10/2018)... ... December 10, 2018 , ... The most active U.S. markets in the ... host the CWCBExpo (Cannabis World Congress) leading B2B trade shows and conferences. ... 29-June 1, 2019, Jacob K. Javits Convention Center, New York, NY , 6th Annual ...
(Date:12/8/2018)... SAN JOSE, Calif. (PRWEB) , ... December 07, ... ... reputable orthopedic surgeon who serves the San Francisco Bay area with ... in his field, and he recognizes the importance of educating patients on the ...
(Date:12/8/2018)... ... December 07, 2018 , ... “The ... juncture in world affairs, U.S. leadership and funding at the United Nations matters. ... strides in reducing extreme poverty and advancing global health plus meaningful reforms in ...
(Date:12/8/2018)... (PRWEB) , ... December 08, 2018 , ... ... whiskerDocs, the leading provider of telehealth support for pet parents, has become an ... companion animals. , “By supporting the advancement of human-animal bond research, ...
Breaking Medicine News(10 mins):
(Date:12/5/2018)... ... December 05, 2018 , ... Trivellini Tech announces the latest version of ... a version previously known as Mamba Nano, Trivellini Long Hair introduces the ability to ... of “Trivellini system has the same capabilities as the last generation but it can ...
(Date:12/5/2018)... Fla. (PRWEB) , ... December 05, 2018 , ... ... navigation and revenue cycle management announced the hiring of Dr. Tony Andrulonis, MBA ... a rapidly growing workforce of over 20,000 medical scribes and support staff. Prior ...
(Date:12/5/2018)... , ... December 04, 2018 , ... ... marks possible for patient safety and quality. Today, the prestigious Leapfrog Group, a ... and Florida Hospital Carrollwood, Florida Hospital Heartland Medical Center Sebring, Florida Hospital Wesley ...
Breaking Medicine Technology:
Cached News: