Patients with multiple sclerosis and fatigue may have abnormal sleep cycles

CHICAGO Fatigue in patients with multiple sclerosis may be related to abnormal or disrupted sleep cycles, according to an article in the April issue of The Archives of Neurology, one of the JAMA/Archives journals.

According to the article, fatigue is the most frequent symptom of multiple sclerosis (MS) and is often difficult to treat. Fatigue is experienced by 76 percent to 92 percent of MS patients and is often profoundly debilitating, the article states.

Hrayr P. Attarian, M.D., of the University of Vermont, Burlington, and colleagues investigated whether circadian rhythm abnormalities or sleep disturbances exist in patients with MS and if they correlate with fatigue and daytime sleepiness. Circadian rhythms are the cycles of sleep and wakefulness, controlled by part of the brain.

The researchers studied 15 patients with MS and fatigue compared with 15 patients with MS without fatigue and 15 healthy people without MS.

The researchers found that of the 15 patients with MS, two had delayed sleep phase, ten had disrupted sleep, and three had normal sleep. One of the 15 non-fatigued MS patients had irregular sleep cycles, two others had disrupted sleep and 12 had normal sleep. All 15 participants without MS had normal sleep. Nine patients with MS and fatigue scored high on a sleep scale test, indicating excessive daytime sleepiness. Only two patients with MS without fatigue scored high on this test. None of the participants without MS were fatigued.

The researchers found a relationship between fatigue and abnormal sleep cycles or disrupted sleep, and between excessive daytime sleepiness and fatigue in MS patients.

"In our series of patients with MS, there was a significantly high probability of a relationship between fatigue and disrupted sleep or abnormal sleep cycles," the authors write. "These abnormalities may be playing a role in the pathophysiology of poorly understood and disabling MS fatigue."


Contact: Jennifer Nachbur
JAMA and Archives Journals

Page: 1

Related medicine news :

1. Patients newly diagnosed with HIV are more likely to enter outpatient care with case management
2. Patients with cancer have highly increased risk for blood clots
3. Patients with previous heart attacks may not benefit from pacemaker implant
4. Patients with cancer detected on screening mammography undergo less toxic treatment
5. Patients with moderate or severe hand dermatitis responsive to drug therapy
6. Patients with abdominal trauma at risk for intra-abdominal infections following surgery
7. Patients who are intubated prior to hospital arrival fare worse find Pitt researchers
8. Patients undergoing weight loss surgery have high rates of H pylori bacteria
9. Patients with chronic sinus do not necessarily develop antibiotic resistance
10. Plastic surgeons honor Patients of Courage overcoming difficult obstacles, inspiring others
11. Patients with severe depression improve using guidelines developed by UT Southwestern researchers

Post Your Comments:

(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun ... NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is ... is geared towards children of all ages; it is a non-competitive, non-timed event, which ...
(Date:10/13/2017)... , ... October 13, 2017 , ... “The Journey: From ... every danger possible to save lost souls in the Philippines. “The Journey: From the ... is a dedicated teacher of the Bible. She has taught all ages and currently ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and fastest ... to open a flagship location in Covington, LA at 401 N. U.S. Highway 190, ... next to Office Depot in the Holiday Square shopping center. Its location allows it ...
(Date:10/12/2017)... ... 12, 2017 , ... Asante, a nationally recognized health system ... their existing home health joint venture through an agreement, effective October 1, 2017, ... venture home health company with Asante, delivering clinically integrated care, for the past ...
(Date:10/12/2017)... ... , ... Leading pediatric oncology experts at Children’s National Health System ... of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by ... Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief of the ...
Breaking Medicine News(10 mins):
(Date:10/5/2017)... ROSEMONT, Ill. , Oct. 5, 2017 /PRNewswire-USNewswire/ ... American Association of Oral and Maxillofacial Surgeons (AAOMS) ... than opioids – to be used as a ... post-surgical pain. ... relationship, the AAOMS White Paper "Opioid Prescribing: Acute ...
(Date:10/4/2017)... Centers for Disease Control and Prevention (CDC), influenza vaccination should take ... communities across Massachusetts , Connecticut , ... through the end of the month. *Some exclusions apply ... ... by the end of October, according to the Centers for Disease Control ...
(Date:10/2/2017)... FLINT, Mich. , Oct. 2, 2017 ... acquired 8th Day Software and Consulting, LLC , ... 8th Day Software, based in Tennessee ... Management LLC. 8th Day expands EnvoyHealth,s service offerings for ... product development. "In ...
Breaking Medicine Technology:
Cached News: