Pediatric autopsies( nfant's death. A five year review and ...),Health

nfant's death. A five year review and examination of 7,058 cases of SIDS has been conducted by Donald H. Chace, James C. DiPerna, Brenda L. Mitchell, Bethany Sgroi, Lindsay F. Hofman and Edwin W. Naylor, all from Neo Gen Screening, Inc., Bridgeville, PA. Their findings are contained in the article, "Electrospray Tandem Mass Spectrometry for Analysis of Acylcarnitines in Dried Postmortem Blood Specimens Collected at Autopsy from Infants with Unexplained Cause of Death," published in the peer-reviewed journal Clinical Chemistry. Clinical Chemistry is the flagship publication of the American Association for Clinical Chemistry (AACC).

The study consisted of postmortem blood and bile specimens collected as dried spots on filter paper from 7,058 cases of SIDS collected from all 50 US states and from most Canadian provinces, as well as a few specimens from other countries. Patients were of all races and primarily infants under one year of age. The number of males and females was roughly equal. More than one half of the specimens were from patients with deaths of unknown cause. The trend of samples from the first 1,000 screening specimens compared with the later specimens showed an increasing number of infants who died of any cause, including SIDS.

Methodology
Each of the samples underwent biochemical screening of numerous metabolic disorders. The screening consisted of acylcarnitine and amino acid profiles were obtained by mass spectometry. Specialized interpretation was used to evaluate profiles for disorders of fatty acid, organic acid, and amino acid metabolism. The analyses of postmortem blood specimens were compared with the analyses of bile specimens, newborn blood specimens, and specimens obtained from older infants at risk for metabolic disorders.

Results
Using the MS/MS-based technology, the researchers discovered that:

• More than 60 (66) specimens suggested diagnoses of metabolic d
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Contact: Donna J. Krupa
djkrupa1@aol.com
American Association for Clinical Chemistry
19-Aug-2002


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