HOME >> MEDICINE >> NEWS
Pegaptanib provides benefit for neovascular age-related macular degeneration

Boston (Dec. 29, 2004) -- Results from two concurrent, prospective, double-blind, multi-center clinical trials show that pegaptanib (Macugen), an anti-vascular endothelial growth factor therapy, is an effective treatment for neovascular age-related macular degeneration (AMD), according to a paper in the Dec. 30 issue of the New England Journal of Medicine. Macugen was approved by the Food and Drug Administration on Dec. 17.

AMD is the leading cause of irreversible, severe loss of vision in people 50 years and older in the developed world and remains an area of unmet medical need. The neovascular or wet form of the disease represents about 10 percent of the overall disease prevalence, but is responsible for 90 percent of the severe vision loss. In wet AMD, abnormal blood vessels grow under the central retina and cause a progressive loss of central vision, interfering with driving, reading and other everyday tasks. As the population ages, almost 1 million people over the age of 55 years in the United States are expected to develop AMD in the next five years, making it a major public health issue in an increasing population of older persons.

The paper in the New England Journal of Medicine details two clinical trials that were held at 117 sites in the Unites States, Canada, Europe, Israel, Australia and South America. Patients were eligible for inclusion if they were 50 years of age or older and had subfoveal choroidal neovascularization caused by AMD and a range of best corrected visual acuity of 20/40 to 20/320 in the study eye and of 20/8000 or better in the other eye. Of the 1,208 patients randomly assigned to treatment in the two studies, (297 patients were assigned to receive 0.3 mg of pegaptanib; 305 patients, 1.0 mg of pegaptanib; 302 patients, 3.0 mg of pegaptanib; and 304 patients, sham injections), 1,190 received at least one study treatment. Treatments were given by injection into the eye.

According to lead author, Evangelos
'"/>

Contact: Todd Ringler
todd.ringler@edelman.com
617-872-1235
Edelman Public Relations
29-Dec-2004


Page: 1 2 3

Related medicine news :

1. Study provides new estimates of the causes of child mortality worldwide
2. Newly identified gene cluster on mouse X chromosome provides insights into fertility
3. New ITN Scholars Program provides junior faculty opportunity to develop clinical trials expertise
4. Study provides clues to alcohols cancer connection
5. International study provides culture-by-culture clues to family violence and abuse
6. Skin sterol provides new information about heart disease risk
7. Novel drug-antidote strategy provides greater control of drug action
8. Survey provides comprehensive look at use of complementary and alternative medicine in US
9. Patient safety study provides first national estimate of adverse events in Canadian hospitals
10. Adding menthol to topical creams for osteoarthritis provides significant pain relief
11. New calculator provides more accurate estimates of colon cancer survival

Post Your Comments:
(Date:6/19/2013)... Tornadoes and their devastating aftermath have increased across the ... to these deadly storms find it hard to recover. ... and corporations from natural and man-made disasters for over ... philosophy of providing a storm shelter that can be ... stand up, with light and a battery-operated blower for ...
(Date:6/19/2013)... Washington, DC (PRWEB) June 19, 2013 ... experiment in the history of managed care. As ... find coverage through the new state-based and federally ... requirements for essential health benefits, and examples of ... some states, industry-leading health business information publisher Atlantic ...
(Date:6/19/2013)... York, NY (PRWEB) June 19, 2013 ... Law Group LLP highlights a recent news story from ... alleged side effects of the hormone-based contraceptive device. The ... those looking to file Mirena lawsuits and ... effects. , The U.S. Food and Drug Administration has ...
(Date:6/19/2013)... (PRWEB) June 19, 2013 As more ... they want to use green energy-saving products to replace ... manufacturer of LED lights, produces a variety of products ... LED bulbs, LED flood light, and LED spot ... down light [ZT-D70-311F] is introduced to customers by Zhongtian ...
(Date:6/19/2013)... (PRWEB) June 19, 2013 Men often deal ... not pay close attention to what they are consuming on ... June, the leading producer and supplier of Siberian pine nut ... of the all-natural healing elements within pine nut ... are the most common ulcers within the gastrointestinal tract that ...
Breaking Medicine News(10 mins):Health News:Radius Engineering International Inc. Tornado-Resistant Storm Shelters 2Health News:New Special Report Provides Comprehensive Overview of New Health Insurance Exchange Marketplaces 2Health News:Rottenstein Law Group LLP Comments on News Reports of Mirena IUD Side Effects 2Health News:3W High Power LED Down Light [ZT-D70-311F] Is Introduced to Customers by Zhongtian Lighting 2Health News:Pine Nut Oil is a Proven Remedy for Stomach Ulcers 2
(Date:6/18/2013)... INDIANAPOLIS , June 18, 2013 The ... LLY ) has declared a dividend for ... on outstanding common stock. The dividend ... at the close of business on August 15, 2013. ... a growing portfolio of pharmaceutical products by applying the ...
(Date:6/18/2013)... , June 18, 2013 Remedy ... for healthcare and life sciences research, today announced ... Administration (GSA) IT Schedule 70 supply contract (GS-35F-367AA, ... to provide innovative IT solutions to government agencies ... with this contract, Remedy has placed its products ...
(Date:6/18/2013)... --  Polymer Technology Systems, Inc. (PTS) announced ... to integrate the CardioChek ® PA system ... systems across the country. The CardioChek PA lipid ... Hanson Medical Systems , offers immediate, on-site ... triglycerides, and glucose. (Logo: http://photos.prnewswire.com/prnh/20130618/DE33611LOGO ...
Breaking Medicine Technology:Remedy Informatics Awarded GSA Contract to Provide Innovative IT Solutions to Federal, State and Local Agencies 2Remedy Informatics Awarded GSA Contract to Provide Innovative IT Solutions to Federal, State and Local Agencies 3Remedy Informatics Awarded GSA Contract to Provide Innovative IT Solutions to Federal, State and Local Agencies 4Polymer Technology Systems, Inc. to Provide Point-of-Care Lipid Testing to Aegis Health Group's Hospital Clients 2Polymer Technology Systems, Inc. to Provide Point-of-Care Lipid Testing to Aegis Health Group's Hospital Clients 3
Cached News: