Penn joins major NCI research initiative to advance breast cancer therapies

(Philadelphia, PA) - The University of Pennsylvania School of Medicine was recently selected to become a member of the National Cancer Institute's Mouse Models of Human Cancers Consortium (MMHCC). The MMHCC was established in 1999 to design and characterize mouse models that more accurately reflect the way that human cancers develop and respond to therapy. The research groups comprising the MMHCC at 24 lead sites connect more than 50 institutions in the US and abroad and focus on mouse models for cancers of major organ systems including prostate, breast, lung, ovary, skin, colon, brain, and the blood and lymph systems.

Lewis A. Chodosh, MD, PhD, Vice Chair, Department of Cancer Biology, Associate Investigator in the Abramson Family Cancer Research Institute, and Program Leader of the Breast Cancer Program at the Abramson Cancer Center, heads one of four MMHCC sites at which breast-cancer models are being developed and studied. Chodosh will oversee a $2.5 million, five-year program based at Penn that encompasses multidisciplinary research from six institutions in three countries. Chodosh's co-principal investigators are: Mitchell D. Schnall, MD, PhD, Associate Chair of Radiology at Penn; Robert D. Cardiff, MD, PhD, of the University of California, Davis; and William J. Muller, PhD, of McGill University.

The Penn Approach - A Focus on Breast Cancer

The goal of the Penn group is to develop new conceptual and technical approaches for understanding the mechanisms of breast tumor progression and metastasis. To accomplish this, Penn researchers will employ a broad array of state-of-the-art cellular and molecular imaging techniques to analyze a series of novel, genetically engineered mouse models of breast cancer. "It's truly a multidisciplinary team effort, bringing together biologists with radiologists, nuclear chemists, physicists, pathologists, and computational biologists," says Chodosh. "This type of endeavor requires a group of scientists w

Contact: Karen Kreeger
University of Pennsylvania School of Medicine

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