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Physicians may need to dig deeper when treating HIV-related lymphomas

otherapy combinations: cyclophosphamide, vincristine, adriamycin and prednisone; or methotrexate, bleomycin, adriamycin, cyclophosphamide, vincristine and dexamethasone.

USC/Norris researchers found that before HAART, overall survival of SNC and DLCL patients was about the same-about six or seven months. But after HAART, patients with DLCL began living significantly longer. DLCL patients' average survival time after HAART's 1996 introduction was 38 months-more than six times as long as SNC patients' average survival time of 5.6 months.

The researchers also found that SNC patients were more likely than DLCL patients to have secondary cancer in their bone marrow, liver and kidneys.

"Prior to the availability of effective treatment against HIV, patients with AIDS-related lymphoma often died of serious infections before they could receive adequate or optimal chemotherapy; the survival of these patients was quite short, in the range of only six months," Levine says. "Importantly, effective anti-HIV treatment has now allowed these patients to receive chemotherapy, and to benefit from it.

"However, our study has shown that not all types of lymphoma are the same, and different treatments will be required to achieve optimal results in these individuals. We expect that our study will eventually serve to change the way in which patients with AIDS-related Burkitt lymphoma are treated."


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Contact: Sarah Huoh
shuoh@usc.edu
323-442-2830
University of Southern California
6-Dec-2004


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