Pioglitazone HCI shown to lower blood pressure in hypertensive patients with type 2 diabetes

Orlando FL, June 5, 2004 Type 2 diabetes and hypertension are commonly associated conditions, both of which carry an increased risk of cardiovascular disease. Results of a large, open-label, multi-center, observational clinical trial show that treatment with the oral anti-diabetic agent pioglitazone HCl in people with type 2 diabetes has beneficial effects in reducing hypertension. The findings were presented today at the American Diabetes Association's 64th Annual Scientific Sessions.

In a study of 3,140 hypertensive patients with type 2 diabetes, all patients received open-label pioglitazone (30 mg/day) for 16 weeks. Hypertension was classified according to current National Institutes of Health guidelines (JNC VII): Stage I: 140-159/90-99 mmHg; Stage II: >160/>100 mmHg. Among patients with Stage I hypertension, pioglitazone elicited a mean decrease of 6.9/3.1 mmHg compared to baseline. In the patients with more severe, Stage II hypertension, pioglitazone was associated with a decrease of 18.7/8.3 mmHg.

"Although increasing clinical evidence suggests that drugs such as pioglitazone have blood pressure lowering effects, until now, those results had not been confirmed in large, unselected patient populations," noted lead investigator Thomas Konrad, M.D., Ass.Prof. Institute for Metabolic Research, Frankfurt, EU RISC- Study Center. "The importance of treating hypertension in patients with type 2 diabetes is particularly crucial because of the high incidence of elevated blood pressure in people with diabetes. A major government study found that almost 80 percent of patients with diabetes also have hypertension, thereby compounding their cardiovascular disease risk. These blood pressure-lowering findings are remarkable, because they suggest that pioglitazone may be able to impact certain cardiovascular disease risk factors in patients with type 2 diabetes."

In patients with type 2 diabetes, management of risk factors beyond diabetes

Contact: Julio Cantre

Page: 1 2

Related medicine news :

1. Pioglitazone shown to reverse thickening of carotid artery wall
2. Cartilage repair techniques shown to restore patient mobility and reduce pain
3. Sprinklers shown effective in slowing dorm fires
4. Controversial drug shown to act on brain protein to cut alcohol use
5. HPV vaccine shown effective at reducing cancer-causing infections
6. HPV vaccine shown to substantially reduce cervical cancer
7. New research results: Heart jacket shown to be effective
8. Isolated soy protein shown to benefit type 2 diabetics, study indicates
9. Increased risk of cardiovascular disease shown in PCOS patients
10. Combination therapy w/ ACTOS (pioglitazone HCI) shown to improve components of diabetic dyslipidemia
11. Anti-eosinophil therapy shown to be effective in treating hypereosinophilic syndrome

Post Your Comments:

(Date:10/13/2017)... ... October 13, 2017 , ... ... PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with clinical associate professor ... prevention of cardiovascular diseases during the 15th Annual Women’s Health Conference. The ...
(Date:10/13/2017)... Shelton, CT (PRWEB) , ... October 13, 2017 , ... ... and long-term care services, staged a mock evacuation of the facility as part of ... Department, Shelton Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) ... a collection of specialty vendors and unique items from across the nation, this holiday-themed ... and wellness services offered by the VNA. The boutique will be open Saturday, ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual ... in Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon ... fun run is geared towards children of all ages; it is a non-competitive, non-timed ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... giving viewers the lowdown on sciatica in a new episode of "Success Files," ... on current events and innovation and investigates each subject in-depth with passion and ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... IRVING, Texas , Oct. 11, 2017  Caris ... science focused on fulfilling the promise of precision medicine, ... Institute has joined Caris, Precision Oncology Alliance™ (POA) as ... leading cancer centers, the St. Jude Crosson Cancer Institute ... to advance the use of tumor profiling, making cancer ...
(Date:10/7/2017)... 6, 2017   Provista, a proven leader ... billion in purchasing power, today announced a new resource ... The Newsroom is the online home for case ... expert bios, news releases, slideshows and events. ... wealth of resources at their fingertips, viewers can also ...
(Date:10/2/2017)... Oct. 2, 2017 Diplomat Pharmacy, Inc. (NYSE: ... Software and Consulting, LLC , and named its founder ... based in Tennessee , will operate ... expands EnvoyHealth,s service offerings for health care partners to ... "In an interoperable world, technology ...
Breaking Medicine Technology:
Cached News: