HOME >> MEDICINE >> NEWS
Pioglitazone shown to reverse thickening of carotid artery wall

Mainz, Germany, November 9, 2004 Clinical study results presented today in New Orleans, Louisiana, during the American Heart Association's Scientific Sessions 2004 proceedings, have shown that the drug pioglitazone (ACTOS, Takeda) significantly reduced the thickness of the carotid (neck) artery in patients with type 2 diabetes. By contrast, no change in carotid thickness was seen in a group of patients who received glimepiride, an older drug for type 2 diabetes.

"These results are provocative, because both drugs showed similar effects on lowering blood glucose, the traditional principal target for type 2 diabetes therapy," noted principal investigator Thomas Forst, Professor for Internal Medicine, Institute for Clinical Research and Development in Mainz, Germany.

"The thickness of the carotid artery is an indicator of atherosclerotic disease, which may both reduce arterial blood flow and set the stage for unstable blood clots in the arteries to dislodge and potentially cause a heart attack or stroke. The reduction in thickness by pioglitazone, a member of a new class of type 2 diabetes drugs called thiazolidinediones (TZDs) suggests that this medication may have benefits beyond improving metabolic control in patients with diabetes mellitus type 2," continued Forst. "This substantial regression of carotid intima media thickness over just 12 or 24 weeks may have important prognostic implications for patients with type 2 diabetes."

Study Design and Results

In the study, B-mode ultrasound was used to measure the intima media thickness (IMT) of the carotid artery before and 12 and 24 weeks after 173 patients received oral therapy with either pioglitazone (45 mg/day) or glimepiride (1-6 mg/day). Baseline carotid IMT was 0.949 0.149mm in the pioglitazone group and 0.924 0.150mm in the glimepiride group (p=n.s.). Carotid IMT was reduced only in the pioglitazone group after 12 weeks (-0.033 0.052mm) vs. -0.002 0.047mm
'"/>

Contact: Kate Sullivan
646-284-6514
Ketchum
9-Nov-2004


Page: 1 2

Related medicine news :

1. Pioglitazone HCI shown to lower blood pressure in hypertensive patients with type 2 diabetes
2. Cartilage repair techniques shown to restore patient mobility and reduce pain
3. Sprinklers shown effective in slowing dorm fires
4. Controversial drug shown to act on brain protein to cut alcohol use
5. HPV vaccine shown effective at reducing cancer-causing infections
6. HPV vaccine shown to substantially reduce cervical cancer
7. New research results: Heart jacket shown to be effective
8. Isolated soy protein shown to benefit type 2 diabetics, study indicates
9. Increased risk of cardiovascular disease shown in PCOS patients
10. Combination therapy w/ ACTOS (pioglitazone HCI) shown to improve components of diabetic dyslipidemia
11. Anti-eosinophil therapy shown to be effective in treating hypereosinophilic syndrome

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Pioglitazone shown reverse thickening carotid artery wall

(Date:10/30/2014)... Nutrition Leaders, a popular online retailer of sports ... is currently hosting a sweepstakes on its official Facebook ... to U.S. residents age 18 and over, and will ... winner will then be selected at random from all ... NutritionLeaders.com. , Nutrition Leaders’ managing director Kimba Vasquez views ...
(Date:10/30/2014)... Riverside, CA (PRWEB) October 30, 2014 ... these terms are synonymous with the craft of web ... and functional website. Yet a simpler solution to create ... , Thus, pictures, videos, contact information, customer reviews and ... website. , "It is the next evolution of ...
(Date:10/30/2014)... 2014 High efficacy and low ... the medical-grade skin care domain: Cosmederm, the specialty ... potent topical dermatological products, today announces the launch ... with patented COSMEDERM®-7 anti-irritant technology. , Formulated ... and 70%) and a low pH (pH 1.2 ...
(Date:10/30/2014)... Austin, TX (PRWEB) October 30, 2014 ... is gifting PreD Store shoppers with a ... taken before meals to reduce post-meal blood sugar spikes. ... overall health is an important part of a diabetes ... on orders will receive one complimentary tube of sugardown. ...
(Date:10/30/2014)... New Haven, CT (PRWEB) October 30, 2014 ... product categories are raising questions about the impact of ... as the marketing method most likely to influence a ... online research poll of 525 consumers conducted by radio ... in four product categories, isolating the results of respondents ...
Breaking Medicine News(10 mins):Health News:Nutrition Leaders Announces Gift Card Sweepstakes 2Health News:Facebook Websites In Thirty-Seconds 2Health News:Cosmederm Redefines Peel Science Standard with Launch of Refinity® Skin Health System 2Health News:Cosmederm Redefines Peel Science Standard with Launch of Refinity® Skin Health System 3Health News:Cosmederm Redefines Peel Science Standard with Launch of Refinity® Skin Health System 4Health News:PreDiabetes Treatment Company Offers PreD Store Shoppers Supplements to Support Healthy Blood Sugar 2Health News:CRN Research On Radio Messaging Effectiveness Now Available In Four Specific Product Categories 2Health News:CRN Research On Radio Messaging Effectiveness Now Available In Four Specific Product Categories 3
(Date:10/30/2014)... , Oct. 30, 2014  TWi Pharmaceuticals, Inc. ... the United States Food and Drug Administration (FDA) on ... Tablets USP, 23 mg, the generic equivalent to Eisai ... Alzheimer,s disease patients. TWi Pharmaceuticals is preparing ... fully owned subsidiary, TWi Pharmaceuticals USA ...
(Date:10/30/2014)... YORK , Oct. 29, 2014 ... the basis of test type, technology, product, and ... register the highest growth rate in the newborn ... This high growth is attributed to various nations ... is a fundamental instrument used for expanded newborn ...
(Date:10/30/2014)... , Oct. 29, 2014   ViaDerma, ... devoted to bringing new products to market, is ... ViaDerma has developed an innovative, patent-pending dual ... mass transfer of pharmaceutical active ingredients to penetrate ... immediate localized therapy. The transdermal delivery method also ...
Breaking Medicine Technology:NewBorn Screening Market by Test Type, Technology (Tandem Mass Spectrometry, Immunoassay, Enzyme Assay, Electrophoresis, Pulse Oximeter), Instrument, Accessories, Reagent & Assay Kit - Global Forecast to 2019 2NewBorn Screening Market by Test Type, Technology (Tandem Mass Spectrometry, Immunoassay, Enzyme Assay, Electrophoresis, Pulse Oximeter), Instrument, Accessories, Reagent & Assay Kit - Global Forecast to 2019 3ViaDerma, Inc. Announces Plans to Pursue Out-Licensing Partnerships in 2015 2ViaDerma, Inc. Announces Plans to Pursue Out-Licensing Partnerships in 2015 3
Cached News: