HOME >> MEDICINE >> NEWS
Pioglitazone shown to reverse thickening of carotid artery wall

Mainz, Germany, November 9, 2004 Clinical study results presented today in New Orleans, Louisiana, during the American Heart Association's Scientific Sessions 2004 proceedings, have shown that the drug pioglitazone (ACTOS, Takeda) significantly reduced the thickness of the carotid (neck) artery in patients with type 2 diabetes. By contrast, no change in carotid thickness was seen in a group of patients who received glimepiride, an older drug for type 2 diabetes.

"These results are provocative, because both drugs showed similar effects on lowering blood glucose, the traditional principal target for type 2 diabetes therapy," noted principal investigator Thomas Forst, Professor for Internal Medicine, Institute for Clinical Research and Development in Mainz, Germany.

"The thickness of the carotid artery is an indicator of atherosclerotic disease, which may both reduce arterial blood flow and set the stage for unstable blood clots in the arteries to dislodge and potentially cause a heart attack or stroke. The reduction in thickness by pioglitazone, a member of a new class of type 2 diabetes drugs called thiazolidinediones (TZDs) suggests that this medication may have benefits beyond improving metabolic control in patients with diabetes mellitus type 2," continued Forst. "This substantial regression of carotid intima media thickness over just 12 or 24 weeks may have important prognostic implications for patients with type 2 diabetes."

Study Design and Results

In the study, B-mode ultrasound was used to measure the intima media thickness (IMT) of the carotid artery before and 12 and 24 weeks after 173 patients received oral therapy with either pioglitazone (45 mg/day) or glimepiride (1-6 mg/day). Baseline carotid IMT was 0.949 0.149mm in the pioglitazone group and 0.924 0.150mm in the glimepiride group (p=n.s.). Carotid IMT was reduced only in the pioglitazone group after 12 weeks (-0.033 0.052mm) vs. -0.002 0.047mm
'"/>

Contact: Kate Sullivan
646-284-6514
Ketchum
9-Nov-2004


Page: 1 2

Related medicine news :

1. Pioglitazone HCI shown to lower blood pressure in hypertensive patients with type 2 diabetes
2. Cartilage repair techniques shown to restore patient mobility and reduce pain
3. Sprinklers shown effective in slowing dorm fires
4. Controversial drug shown to act on brain protein to cut alcohol use
5. HPV vaccine shown effective at reducing cancer-causing infections
6. HPV vaccine shown to substantially reduce cervical cancer
7. New research results: Heart jacket shown to be effective
8. Isolated soy protein shown to benefit type 2 diabetics, study indicates
9. Increased risk of cardiovascular disease shown in PCOS patients
10. Combination therapy w/ ACTOS (pioglitazone HCI) shown to improve components of diabetic dyslipidemia
11. Anti-eosinophil therapy shown to be effective in treating hypereosinophilic syndrome

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Pioglitazone shown reverse thickening carotid artery wall

(Date:11/24/2014)... 2014 A new sports massage ... pain-relief service and massage therapy provider, announced it ... This newest sports massage is a ... between traditional sports massage and ESM is that ... very own "reset button,” and ESM can increase ...
(Date:11/24/2014)... Raymond, Alberta (PRWEB) November 24, 2014 ... of people each day. They break up families, ... there is new hope for those that suffer,” ... “Ground-breaking scientific research is showing that our specialized ... , Hardy will appear on “Mind Over Matter”, ...
(Date:11/24/2014)... Dr. Michael Kettel , a leading fertility ... NBC to discuss egg freezing as a viable and increasingly ... the news recently, with new company benefits at Facebook and ... , “[The companies] see it as a way to take ... path.” Says Dr. Kettel. , Up until a few weeks ...
(Date:11/23/2014)... 2014 The report, “Market Snapshot: ... 2020 - Asia-Pacific” provides quantitative analysis of the ... minimally invasive body contouring devices, non-invasive body contouring ... market size data by revenue and volume over ... China, Japan, South Korea, Australia and India. It ...
(Date:11/23/2014)... 2014 (HealthDay News) -- The holidays can be a ... overload can trigger major meltdowns, an expert says. ... of circumstances, but when you have children with special ... occupational therapy professor at University of the Sciences in ... best to let your hosts or visitors know what ...
Breaking Medicine News(10 mins):Health News:Sports Massage in London by Massaggi Presents New Technique to Reset Muscles, Rapidly Eliminate Pain 2Health News:Sports Massage in London by Massaggi Presents New Technique to Reset Muscles, Rapidly Eliminate Pain 3Health News:Nutritional Mental Health Treatment Featured on Access Health Airing on Lifetime Television® 2Health News:Nutritional Mental Health Treatment Featured on Access Health Airing on Lifetime Television® 3Health News:Dr. Michael Kettel of San Diego Fertility Center Gives “An Inside Look at Freezing Eggs” on NBC 2Health News:Dr. Michael Kettel of San Diego Fertility Center Gives “An Inside Look at Freezing Eggs” on NBC 3Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 2Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 3Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 4Health News:Holidays Can Be Sensory Overload for Kids With Autism 2
(Date:11/22/2014)... DUBLIN , Nov. 21, 2014 Research ... "China Recombinant Protein Drug Industry Report, 2014-2017" report ... The Chinese recombinant protein drug market ... demand rigidity, consumption ability and the like. During 2005-2013, ... hospitals grew at a CAGR of 19.1%, and it ...
(Date:11/21/2014)... COLLEGE PARK, Md. , Nov. 21, 2014 /PRNewswire-USNewswire/ ... Engineering today will host the ceremonial groundbreaking of the ... Maryland, College Park. The new building will cultivate transformative ... human health.  Taking place at 10:00 a.m. ... building in the Paint Branch Parking Lot, adjacent to ...
(Date:11/21/2014)... 2014 In September 2014, the staff at ... a new product development plan that started with the ... lab coat , aptly named "Vera G.," after ... the world. The new women,s designer lab coat is ... sleek envelope collar, vertical princess and high waist seaming, ...
Breaking Medicine Technology:China Recombinant Protein Drug Industry Report, 2014-2017 2China Recombinant Protein Drug Industry Report, 2014-2017 3University of Maryland Breaks Ground for A. James Clark Hall 2University of Maryland Breaks Ground for A. James Clark Hall 3University of Maryland Breaks Ground for A. James Clark Hall 4Medelita Introduces Medical Industry's First Limited Edition Women's Designer Lab Coat 2
Cached News: