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Pioglitazone shown to reverse thickening of carotid artery wall

in the glimepiride-treated patients (p = 0.0002 between groups) and after 24 weeks of treatment (-0.054 0.059mm vs. -0.011 0.058mm, respectively, p < 0.0001 between groups). In addition, insulin resistance was significantly improved in the pioglitazone group (-2.21 3.40 vs. -0.27 3.30, p < 0.0001 between groups). Changes in IMT correlated with improvement in insulin resistance (r=0.29, p<0.001) and were independent from the improvement in metabolic control.

The population included 66 females and 107 males with type 2 diabetes aged 62.6 +/- 1 7.9 years, with a mean body mass index (BMI) of 31.8 (generally classified as obese). Both treatments were generally well tolerated.


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9-Nov-2004


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