Pittsburgh researcher receives national award: Finds new ways to make molecules used as anti-cancer drugs

Finds new ways to make molecules used as anti-cancer drugs

Chemist Dennis P. Curran of Pittsburgh, Penn., will be honored on March 28 by the world's largest scientific society for finding new ways to make molecules used as anti-cancer drugs. He will receive the American Chemical Society Award for Creative Work in Synthetic Organic Chemistry at the Society's national meeting in San Francisco.

Curran specializes in radical chemistry at the University of Pittsburgh, where he is the Bayer Professor of Chemistry as well as a Distinguished Service Professor. Simply put, he uses free radicals to explore new ways to assemble compounds.

Fifteen years ago, free radicals - the kind of molecules that opened up the ozone hole over Antarctica, for example - were considered too reactive to be useful in the laboratory. But adventurous researchers like Curran have found conditions and strategies to channel that "hyperreactivity" in useful directions.

For example, Curran's team has been working for the past 10 years on compounds derived from camptothecin, an anti-cancer agent originally found in a common tree in China.

"At the beginning, we were just trying to develop a new way to make five-membered rings (of carbon)," he said. "Our method worked, but then the radical went on to make a six-membered ring. We looked at it and said hey, that looks like a big piece of camptothecin."

Camptothecin exhibits good tumor-killing activity in the test tube, but it is broken down too quickly in the body to be useful in treating cancer. Two derivatives of camptothecin have proven more stable and are currently on the market.

Curran's group first developed a free-radical synthesis of camptothecin. Now, the group is applying those techniques to making hundreds of candidate derivatives. Several of them, so far tested in mice, appear to share the current products' anti-cancer action but are even more stable - potentially allowing a lower dose of chemotherap

Contact: Christina Curtin
American Chemical Society

Page: 1 2

Related medicine news :

1. Lead in the environment causes violent crime, reports University of Pittsburgh researcher at AAAS
2. University of Pittsburgh researcher gets CDC grant to study youth violence
3. University of Pittsburgh finds that people would trade longevity for quality end-of-life care
4. University of Pittsburgh approach has lung recipients taking far fewer drugs
5. Botox helps ease symptoms of enlarged prostate according to Univ. of Pittsburgh study
6. University of Pittsburgh researchers identify potential biomarker for renal cell carcinoma
7. Overactive bladder symptoms affect sexual activity of women says Univ. of Pittsburgh study
8. Prostate cancer marker could lead to earlier diagnosis say Univ. of Pittsburgh researchers
9. Univ. of Pittsburgh researcher presents six-year results of botox injections for bladder dysfunction
10. Drug for depression helps irritable bowel syndrome, according to Pittsburgh study
11. Intensive diabetes management yields positive results, according to Pittsburgh project

Post Your Comments:

(Date:12/8/2018)... (PRWEB) , ... December 08, 2018 , ... ... whiskerDocs, the leading provider of telehealth support for pet parents, has become an ... companion animals. , “By supporting the advancement of human-animal bond research, ...
(Date:12/6/2018)... SALT LAKE CITY and KENOSHA, Wisc. (PRWEB) , ... December 06, ... ... first Division I NCAA Team to purchase and install LED light fixtures containing ... room. , “We are excited to be at the forefront of collegiate gymnastics programs ...
(Date:12/5/2018)... , ... December 05, 2018 , ... A well-known name ... fitness content to the masses. Wellbeats , which has delivered on-demand, virtual fitness ... new Wellbeats consumer app. Available now in the Apple App Store, the Wellbeats ...
(Date:12/5/2018)... ... December 05, 2018 , ... What is Rosacea: ... are poorly understood. It manifests on the face, especially the cheeks, chin, nose ... cause enormous social and psychological problems. , Although it is considered incurable, the ...
(Date:12/5/2018)... ... December 04, 2018 , ... Earthly Mist, Edmond, ... E 4th Street. , The dispensary will serve Edmond, Oklahoma residents who present ... with patients to find the correct medical cannabis product based on their doctor’s ...
Breaking Medicine News(10 mins):
(Date:12/6/2018)... PALM BEACH, Fla. (PRWEB) , ... December 06, 2018 , ... ... with “Speak Up for Kids Palm Beach”. The nonprofit serves 1500 children countywide who ... of addiction, but is also fighting against the stigma that surrounds local treatment centers. ...
(Date:12/5/2018)... (PRWEB) , ... December 05, 2018 , ... WHO: The ... worldwide , WHAT: Livestreaming of four keynote addresses and five spotlight sessions ... Care (see below for session descriptions and speakers) , WHEN: Beginning Tuesday, December 11 ...
(Date:12/5/2018)... ... 2018 , ... Florida Hospital West Florida Division has once ... prestigious Leapfrog Group, a national nonprofit health care ratings organization, announced the Top ... Sebring, Florida Hospital Wesley Chapel and Florida Hospital Zephyrhills all received the Top ...
Breaking Medicine Technology:
Cached News: