HOME >> MEDICINE >> NEWS
Placebo, antidepressant may lift depression via common mechanism

Whether it's a widely prescribed medication or a placebo, a successful treatment for depression must trigger a common pattern of brain activity changes, suggests a team of researchers funded by the National Institute of Mental Health.

Using functional brain imaging, Helen Mayberg, M.D., and colleagues at the University of Texas Health Science Center, San Antonio, have found increased activity in the cortex accompanied by decreases in limbic regions in patients who responded to either the popular antidepressant fluoxetine or to a placebo. They propose that this pattern of changes may be necessary for therapeutic response. However, patients who responded to fluoxetine also experienced unique changes in lower areas -- brainstem, striatum and hippocampus -- thought to confer additional advantage in sustaining the response long term and preventing relapse. The researchers report on their Positron Emission Tomography (PET scan) study in the May 2002 American Journal of Psychiatry. "Our findings do not support the notion that antidepressants work merely via a placebo effect," cautioned Mayberg, who has since moved to the Rotman Research Institute at the University of Toronto. "Patients on active medication who failed to improve did not sustain the brainstem, striatal and hippocampus changes unique to antidepressant responders."

In the randomized, double blind trial, 17 middle-aged men, hospitalized for unipolar depression, received either fluoxetine or placebo for 6 weeks. Rating scales revealed that 4 of the men responded to placebo and another 4 showed comparable improvement with the active medication. Nine patients failed to get better.

"Treatment with placebo is not absence of treatment, just absence of active medication," note the researchers, citing possible therapeutic benefits of a change in environment and the supportive, therapeutic milieu of an inpatient psychiatric ward.

PET scans traced the destination of a radi
'"/>

Contact: Jules Asher
NIMHpress@nih.gov
301-443-4536
NIH/National Institute of Mental Health
1-May-2002


Page: 1 2

Related medicine news :

1. Brain activity prior to treatment flags vulnerability to antidepressant side effects
2. Costs of antidepressants could have funded effective alternatives
3. Depression may explain higher risk of heart attack associated with antidepressants
4. Suicidal behaviour caused by antidepressants cannot be ruled out
5. Common antidepressants lower effects of tamoxifen in many women
6. Common antidepressant may affect youths bone development
7. Cognitive behavioral therapy combined with antidepressant effective in treating adolescent OCD
8. Adrenaline packs a powerful punch in the use of antidepressants
9. Unpublished trials data suggest most SSRI antidepressants unsuitable for children
10. Preschoolers lead growth of antidepressant use, study reveals
11. Worrying rise in use of antidepressants in children

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/24/2017)... ... February 24, 2017 , ... ... which specializes in thought leadership , media relations, social media, content marketing ... that will be powered through Act-On, an intuitive marketing automation platform. , Rosica ...
(Date:2/23/2017)... Boston, MA (PRWEB) , ... February 23, 2017 ... ... Education and Department of Justice jointly issued a letter to withdraw ... in accordance with their gender identity. The guidance issued in May 2016 by ...
(Date:2/23/2017)... Chapel Hill, NC (PRWEB) , ... February 23, 2017 , ... ... the Platinum Sponsor for ACPA’s 74th Annual Meeting. KLS is a longtime supporter ... in 2017 as an exhibitor and Platinum Sponsor," said Dr. Bob Havlik, 2017 ACPA ...
(Date:2/23/2017)... Mass. (PRWEB) , ... February 23, 2017 , ... ... as an approved content provider for the National Institute for Health and ... and social care-related organizations in the National Health Service (NHS) to search, order ...
(Date:2/23/2017)... ... February 23, 2017 , ... ERT, a global ... announced that Premier Research, a leading clinical development service provider, has selected ERT’s ... increasingly complex, due in part to an array of circumstances including the use ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... 2017 Following receiving ... , s AMAR is a major milestone for ... M w ound care market in ... BST for inclusion in the National Health Basket , ...   E-QURE Corp. (OTCQB: EQUR), a leader in medical ...
(Date:2/24/2017)... -- Research and Markets has announced the addition of the ... to their offering. ... latest research Dry eye Drugs Price Analysis and Strategies - 2016, provides ... The research answers the following questions: What ... How are they positioned in the Global Dry eye market? ...
(Date:2/24/2017)... Md. , Feb. 23, 2017 ... marketing of the PhenoTest BC Kit, performed on ... to identify organisms that cause bloodstream infections and ... likely to respond to (antibiotic sensitivity). The test ... to provide this important information, which can guide ...
Breaking Medicine Technology:
Cached News: