HOME >> MEDICINE >> NEWS
Placebo, antidepressant may lift depression via common mechanism

Whether it's a widely prescribed medication or a placebo, a successful treatment for depression must trigger a common pattern of brain activity changes, suggests a team of researchers funded by the National Institute of Mental Health.

Using functional brain imaging, Helen Mayberg, M.D., and colleagues at the University of Texas Health Science Center, San Antonio, have found increased activity in the cortex accompanied by decreases in limbic regions in patients who responded to either the popular antidepressant fluoxetine or to a placebo. They propose that this pattern of changes may be necessary for therapeutic response. However, patients who responded to fluoxetine also experienced unique changes in lower areas -- brainstem, striatum and hippocampus -- thought to confer additional advantage in sustaining the response long term and preventing relapse. The researchers report on their Positron Emission Tomography (PET scan) study in the May 2002 American Journal of Psychiatry. "Our findings do not support the notion that antidepressants work merely via a placebo effect," cautioned Mayberg, who has since moved to the Rotman Research Institute at the University of Toronto. "Patients on active medication who failed to improve did not sustain the brainstem, striatal and hippocampus changes unique to antidepressant responders."

In the randomized, double blind trial, 17 middle-aged men, hospitalized for unipolar depression, received either fluoxetine or placebo for 6 weeks. Rating scales revealed that 4 of the men responded to placebo and another 4 showed comparable improvement with the active medication. Nine patients failed to get better.

"Treatment with placebo is not absence of treatment, just absence of active medication," note the researchers, citing possible therapeutic benefits of a change in environment and the supportive, therapeutic milieu of an inpatient psychiatric ward.

PET scans traced the destination of a radi
'"/>

Contact: Jules Asher
NIMHpress@nih.gov
301-443-4536
NIH/National Institute of Mental Health
1-May-2002


Page: 1 2

Related medicine news :

1. Brain activity prior to treatment flags vulnerability to antidepressant side effects
2. Costs of antidepressants could have funded effective alternatives
3. Depression may explain higher risk of heart attack associated with antidepressants
4. Suicidal behaviour caused by antidepressants cannot be ruled out
5. Common antidepressants lower effects of tamoxifen in many women
6. Common antidepressant may affect youths bone development
7. Cognitive behavioral therapy combined with antidepressant effective in treating adolescent OCD
8. Adrenaline packs a powerful punch in the use of antidepressants
9. Unpublished trials data suggest most SSRI antidepressants unsuitable for children
10. Preschoolers lead growth of antidepressant use, study reveals
11. Worrying rise in use of antidepressants in children

Post Your Comments:
(Date:7/1/2015)... ... 2015 , ... With all final regulatory approvals in place ... N.Y., is now a member of national system Trinity Health, effective immediately. ... committed to delivering high-value care, said Richard J. Gilfillan, M.D., president and CEO, ...
(Date:7/1/2015)... (PRWEB) , ... July 01, 2015 , ... ... against the manufacturers of Levaquin ( http://www.injurybeacon.com/levaquin/lawsuit/ ) has granted the Defendants’ Motion ... Southern District of West Virginia on June 26th, the Court rejected the Plaintiff’s ...
(Date:7/1/2015)... York, NY (PRWEB) , ... July 01, 2015 ... ... largest non-profit organization devoted exclusively to funding innovative lymphoma research and serving the ... services – today announced that they will welcome four new members to their ...
(Date:7/1/2015)... ... July 01, 2015 , ... A healthy eating ... chickens and eggs. Eating organic foods and products can help limit the exposure ... friendly than production chicken farming. Choosing home raised chickens and eggs that do ...
(Date:7/1/2015)... ... , ... The Collaborative for Children and Families (CCF) announced that it received ... CCF to improve quality of care and save costs for the child welfare sector ... changes in New York’s Medicaid system. Experts agree that children need thorough solutions to ...
Breaking Medicine News(10 mins):Health News:St. Joseph’s Health Now a Member of Trinity Health 2Health News:St. Joseph’s Health Now a Member of Trinity Health 3Health News:St. Joseph’s Health Now a Member of Trinity Health 4Health News:Levaquin Lawsuit Attorneys at Bernstein Liebhard LLP Comment on Decision to Grant Summary Judgment in Generic Drug Case 2Health News:Levaquin Lawsuit Attorneys at Bernstein Liebhard LLP Comment on Decision to Grant Summary Judgment in Generic Drug Case 3Health News:Lymphoma Research Foundation Welcomes New Scientific Advisory Board Members 2Health News:Lymphoma Research Foundation Welcomes New Scientific Advisory Board Members 3Health News:Lymphoma Research Foundation Welcomes New Scientific Advisory Board Members 4Health News:Lymphoma Research Foundation Welcomes New Scientific Advisory Board Members 5Health News:Chicken Coop Condo Offer New Chicken Coop Designs 2Health News:The Collaborative for Children and Families Receives a Grant From The New York Community Trust to Build Capacity for Comprehensive Child Welfare 2Health News:The Collaborative for Children and Families Receives a Grant From The New York Community Trust to Build Capacity for Comprehensive Child Welfare 3
(Date:7/1/2015)... -- Research and Markets( http://www.researchandmarkets.com/research/46q6x8/2015_strategies ... "2015 Strategies in the Home/Self Testing Market" ... 175-page report provides analysis of the major home/self ... pregnancy, ovulation, and occult blood. The report presents ... competitive profiles. The growing economic pressures ...
(Date:7/1/2015)... FT LAUDERDALE, Florida , July 1, 2015 ... and marketer of innovative medical devices for the treatment of ... prevailed in a final opposition appeal hearing in the European ... - STENT HAVING HELICAL ELEMENTS (,482). The ,482 patent has ... has been upheld as a valid patent in amended form. ...
(Date:7/1/2015)... HEIGHTS, Utah , July 1, 2015 /PRNewswire/ ... ), a manufacturer and marketer of rehabilitation and ... completed its $4,025,000 private placement financing led by ... strategic private equity investor focused on the healthcare ... to promote organic growth and pursue potential strategic ...
Breaking Medicine Technology:2015 Strategies in the Home/Self Testing Market 2OrbusNeich Announces Favorable Ruling from the European Patent Office and Initiation of Litigation Against Terumo Corporation 2Dynatronics Announces Completion Of $4,025,000 Private Placement Led By Prettybrook Partners 2Dynatronics Announces Completion Of $4,025,000 Private Placement Led By Prettybrook Partners 3
Cached News: