Polish Dumpling-Like Particle Has Potential In Drug Delivery

Chemists at Washington University in St. Louis have created synthetic polymer particles that are as cute as dumplings..

They're called knedels (k-ned-l), after a popular Polish dumpling filled either with meat or sweets. While the Polish knedel is a sumptuous taste treat, the Washington University knedl is a synthetic nano-sized particle that its creators hope someday will be the carrier of drugs or genes for biomedical applications and therapies.

Karen Wooley, Ph.D., assistant professor of chemistry at Washington University, recently announced a new breakthrough in the particle that K. Bruce Thurmond, II, a graduate student in Wooley's group, first synthesized in 1996. Wooley and post-doctoral researcher Haiyong Huang, Ph.D., have changed the composition of their knedel's core from a glassy to a rubbery substance similar to the interior of a golf ball. Additionally, this core can be hollowed out, creating a capsule into which large amounts of drugs -- or DNA, for gene therapy -- may be loaded for delivery.

Huang presented a talk on the advance at the Spring Meeting of the American Chemical Society, March 29, in Dallas, TX.

"They're like golf ball molecules in this form" says Wooley. "This advance moves us along in our goal of making knedels potential drug- and gene- carrying systems. It makes the particle a lot more versatile and the rubbery core should allow a higher loading capacity We've gotten lots of interest in the knedels, for their potential, they're novelty, and their name."

The work is funded by the National Science Foundation and Monsanto Company, St. Louis.

Wooley and her colleagues recently have been focusing on the knedel's water-soluble shell that allows them to bind DNA to its surface. This in turn causes small aggregates to form that protect the genetic material from being digested by enzymes. The chemists charge the shell positively so the knedel attracts DNA, which has a negative charge.

Contact: Tony Fitzpatrick
(314) 935-5272
Washington University in St. Louis

Page: 1 2 3

Related medicine news :

1. Polishing the crystal ball: risk prediction methods need update
2. Potential treatment for Fragile X Syndrome demonstrated in fruit fly model
3. Potential drug target for treating cocaine abuse found
4. Potential cure for lymphoma in HIV patients
5. Potentially fatal toxicities occur with off-label use of cancer drugs
6. Potentially blinding eye disease more prevalent than previously thought
7. Potential genetic links discovered between metabolic syndrome, diabetes and cardiovascular disease
8. Potential low-cost options for monitoring HIV-1-infected children in less-developed countries
9. Immunexs TRAIL Molecule Shows Potential As Anti-Tumor Agent
10. Study Shows Potential For Quelling AIDS Nerve Pain
11. Increased Public Access To Defibrillation Could Prove Potentially Cost-Effective And Life-Saving

Post Your Comments:

(Date:5/16/2019)... ... 16, 2019 , ... AdventHealth West Florida Division announced today ... Tampa Bay. Today, the prestigious Leapfrog Group, a national nonprofit health care ratings ... about a third of those hospitals received an “A” grade, including seven in ...
(Date:5/15/2019)... ... May 16, 2019 , ... Statistical Concepts ... p.m. - 3:00 p.m. EDT, https://www.fdanews.com/statisticalconceptsprocessvalidation , Devicemakers: Are the organizations ... or even maybe … Dan O’Leary is here to help. Dan is FDAnews’s ...
(Date:5/14/2019)... ... 15, 2019 , ... Tune in Wednesday, May 15 at 7pm for the Healthy Woman Show ... Excellence highlights bladder control problems that are embarrassing and inconvenient for women. , “We ... and you spend more time away from your home. Our goal is to help ...
(Date:5/14/2019)... ... 2019 , ... The Atlanta Falcons, the Baltimore Ravens and ... the U.S. who rely on HydroWorx aquatic therapy pools to care for their ... healing,” said Timothy McCarthy, Chief Executive Officer for HydroWorx. “Whether it’s for ...
(Date:5/14/2019)... , ... May 14, 2019 , ... ... Dallas, TX, has been named by Modern Healthcare as one of the nation's Best Places to ... has been awarded this title, which comes on the heels of being named ...
Breaking Medicine News(10 mins):
(Date:5/16/2019)... ... May 16, 2019 , ... Actuate Therapeutics, Inc., a clinical stage biopharmaceutical ... The Series B is led by Kairos Ventures, with DEFTA Partners, Tech Coast ... the financing to expand the company’s ongoing Phase 1 / 2 clinical trial and ...
(Date:5/16/2019)... ... May 16, 2019 , ... Guruji ... today’s issues affecting humanity at practical and spiritual levels. , Founder of ... connection to the God of their understanding, as well as, to illuminate the ...
(Date:5/16/2019)... ... May 16, 2019 , ... Luma Health ... launched Mobile Patient Intake. This new solution helps providers deliver a top-notch patient ... own convenience, on their device of choice, days or weeks prior to their ...
Breaking Medicine Technology:
Cached News: