HOME >> MEDICINE >> NEWS
Polish Dumpling-Like Particle Has Potential In Drug Delivery

Chemists at Washington University in St. Louis have created synthetic polymer particles that are as cute as dumplings..

They're called knedels (k-ned-l), after a popular Polish dumpling filled either with meat or sweets. While the Polish knedel is a sumptuous taste treat, the Washington University knedl is a synthetic nano-sized particle that its creators hope someday will be the carrier of drugs or genes for biomedical applications and therapies.

Karen Wooley, Ph.D., assistant professor of chemistry at Washington University, recently announced a new breakthrough in the particle that K. Bruce Thurmond, II, a graduate student in Wooley's group, first synthesized in 1996. Wooley and post-doctoral researcher Haiyong Huang, Ph.D., have changed the composition of their knedel's core from a glassy to a rubbery substance similar to the interior of a golf ball. Additionally, this core can be hollowed out, creating a capsule into which large amounts of drugs -- or DNA, for gene therapy -- may be loaded for delivery.

Huang presented a talk on the advance at the Spring Meeting of the American Chemical Society, March 29, in Dallas, TX.

"They're like golf ball molecules in this form" says Wooley. "This advance moves us along in our goal of making knedels potential drug- and gene- carrying systems. It makes the particle a lot more versatile and the rubbery core should allow a higher loading capacity We've gotten lots of interest in the knedels, for their potential, they're novelty, and their name."

The work is funded by the National Science Foundation and Monsanto Company, St. Louis.

Wooley and her colleagues recently have been focusing on the knedel's water-soluble shell that allows them to bind DNA to its surface. This in turn causes small aggregates to form that protect the genetic material from being digested by enzymes. The chemists charge the shell positively so the knedel attracts DNA, which has a negative charge.
'"/>

Contact: Tony Fitzpatrick
p72245tf@wuvmd.wustl.edu
(314) 935-5272
Washington University in St. Louis
19-May-1998


Page: 1 2 3

Related medicine news :

1. Polishing the crystal ball: risk prediction methods need update
2. Potential treatment for Fragile X Syndrome demonstrated in fruit fly model
3. Potential drug target for treating cocaine abuse found
4. Potential cure for lymphoma in HIV patients
5. Potentially fatal toxicities occur with off-label use of cancer drugs
6. Potentially blinding eye disease more prevalent than previously thought
7. Potential genetic links discovered between metabolic syndrome, diabetes and cardiovascular disease
8. Potential low-cost options for monitoring HIV-1-infected children in less-developed countries
9. Immunexs TRAIL Molecule Shows Potential As Anti-Tumor Agent
10. Study Shows Potential For Quelling AIDS Nerve Pain
11. Increased Public Access To Defibrillation Could Prove Potentially Cost-Effective And Life-Saving

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2021)... , ... March 29, 2021 , ... ... the 21st Century , A Virtual Workshop Presented by WCG FDAnews and Cerulean ... 4:30 pm EDT, https://wcg.swoogo.com/modern-sop-and-quality-systems , Are one’s SOPs written for the ...
(Date:3/30/2021)... ... March 29, 2021 , ... According to data released ... reproductive age (13-44) in need of publicly funded contraception live in counties impacted by ... Colorado’s 64 counties have lost some of their Title X resources. , The ...
(Date:3/30/2021)... ... March 29, 2021 , ... Health Literacy Innovations (HLI), a ... confusion due to low health literacy today announces a new partnership with the ... work with ACAP’s member Safety Net Health Plans, those that provide comprehensive health ...
(Date:3/30/2021)... ... ... Dr. Colin Campbell is proud to announce the 1 year anniversary in their new state ... internal medicine and is a primary care specialist who has been practicing for 23 years. ... keep South Jersey healthy one patient at a time. , “Over the past year, Dr. ...
(Date:3/30/2021)... ... March 30, 2021 , ... The COVID-19 ... and survivors; their families; and their caregivers. Crossroads4Hope is addressing the needs of ... emotional support system, MyGo2Support, which meets needs of people impacted by cancer, no ...
Breaking Medicine News(10 mins):
(Date:3/30/2021)... ... March 29, 2021 , ... The University of Texas Health Science Center ... San Antonio Multispecialty and Research Hospital, a destination center for research and treatment of ... In a nod to the COVID-19 pandemic, the ceremony was held virtually. , William ...
(Date:3/30/2021)... ... March 29, 2021 , ... Iora Health ... primary care, has partnered with Devoted Health , one of the fastest-growing ... across Maricopa County and provides seniors with the highest-quality care and experience possible, ...
(Date:3/30/2021)... CITY (PRWEB) , ... March 29, 2021 , ... ... has joined the Vaccine Credential Initiative (VCI), a group bringing together leading health ... record of vaccination status, based on open, interoperable standards. By joining the VCI ...
Breaking Medicine Technology:
Cached News: