HOME >> MEDICINE >> NEWS
Poor adherence to control measures for older children with phenylketonuria

Authors of a research letter in this week's issue of THE LANCET highlight how older children are less likely to adhere to recommended guidelines to control phenylketonuria (PKU), a metabolic disorder which can cause severe cognitive impairment.

PKU is one of the most frequent inherited metabolic disorders, with a prevalence of about one in 14,000 babies in populations of European descent. The disorder (caused by mutations within the gene for the enzyme phenylalanine hydroxylase), results in a failure to convert phenylalanine to tyrosine in the liver. The accumulation of phenylalanine prevents normal postnatal brain development and leads to severe learning difficulties. Screening at birth to identify individuals with the disorder, and regulation of blood concetrations of phenylalanine by a low-protein diet in affected children can result in normal cognitive functioning in adulthood.

John Walter from the Royal Manchester Childrens Hospital, UK, and colleagues assessed data from 4 PKU centres (three in the UK and one from Australia) to estimate the adherence to PKU control among younger and older children. Children younger than 10 years had substantially fewer phenylalanine concentrations above the recommended limit for PKU control compared with children older than 15 years (30% compared with 80%, respectively). Similar results were observed for the frequency of blood testing; more than 80% of children younger than 10 years had the recommended frequency of blood testing, compared with less than half of children aged 15 years or older.

John Walter comments: "Our findings indicate that adolescents and young adults generally do not comply with recommendations for the monitoring and control of phenylalanine concentrations. If phenylketonuria is proven to be dangerous in adults as it is in infants, maintenance of good dietary control beyond childhood will become increasingly important, and more acceptable modes of treatment than available will need
'"/>

Contact: Richard Lane
richard.lane@lancet.com
44-20-7424-4949
Lancet
4-Jul-2002


Page: 1 2

Related medicine news :

1. Study finds that adherence to diet, not type of diet, more important factor for losing weight
2. New study shows patients experience asthma variability, despite strict adherence to guidelines
3. New technology facilitates adherence for patients
4. Perception of punishment undermines HIV treatment adherence
5. Multiple characteristics of HAART affect adherence
6. Cocaine use linked to poor adherence to antiretroviral therapy in HIV patients
7. Drug regimen adherence key in keeping babies virus-free, study suggests
8. Are people with HIV sticking to their medication treatment regimens? New method measures patient adherence
9. Study compares efficacy and adherence to triple nucleoside therapy Ziagen + Combivir with protease inhibitor plus Combivir regimens in therapy-nave
10. Social support and confidence predict medication adherence for AIDS patients
11. Medication helps alcoholics control drinking

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/9/2020)... ... ... Introducing TheCBDHaven.com, a new way to buy CBD online . , We believe in ... at affordable prices. We are working on adding new brands soon. , At TheCBDHaven.com, you ... believe in educating our community. Make sure to check out our very informative ...
(Date:4/5/2020)... ... April 03, 2020 , ... United Security Health and Casualty ... Major Medical (STMM) plan in the state of Oklahoma. Lisa Cordero, COO, United ... for millions of Americans in all financial situations. STMM can be a bridge, providing ...
(Date:4/2/2020)... ... 02, 2020 , ... FDA CDS Software Regulation:, The Latest ... 1:30-3:00 p.m. EDT, https://www.fdanews.com/cdssoftwareregulation , *NEW: The webinar ... management of the Coronavirus.* , Is one’s software regulated as a medical device? ...
(Date:4/1/2020)... , ... April 02, 2020 , ... ... 2020, 3:00 pm PT/6:00 pm ET- to discuss surgical safety practices in response ... in Maryland, Louisiana State University Healthcare Network in New Orleans and Amsterdam University ...
(Date:4/1/2020)... ... April 01, 2020 , ... Global mobile data platform provider Zerion Software announced ... new needs based on COVID-19. , As cases continue to rise across the world, ... Zerion will extend support by offering free basic iFormBuilder accounts and forms - including ...
Breaking Medicine News(10 mins):
(Date:4/2/2020)... ... April 02, 2020 , ... Planning an Audit Response:, How to Handle MDSAP ... the contrary, having nonconformities spotted by a notified body during an audit does happen. ... strict deadline and under pressure with only 15 days to craft a response to ...
(Date:4/1/2020)... ... April 01, 2020 , ... Care Station Medical Group -- ... implemented a number of changes to better care for our community. As New Jersey's ... hours and crafted new ways to offer medical care to patients coping with COVID-19. ...
(Date:3/30/2020)... ... March 30, 2020 , ... ... new solution, TalkWithYourDoc.com . By leveraging technology developed by its wholly ... sizes to continue offering revenue-generating healthcare services while serving patients’ needs during the ...
Breaking Medicine Technology:
Cached News: