Possible Mechanism For Estrogen Memory Enhancement Found

University of Southern California neuroscientists have found a chemical mechanism that explains how estrogen enhances the process believed responsible for memory.

"Previous studies have suggested that the hormone estrogen delays the onset of Alzheimer's disease, and several million post-menopausal women are taking estrogen supplements for that reason," says USC neurophysiologist Richard F. Thompson, Ph.D. "Our research reveals a chemical mechanism that could explain how the delay in onset occurs."

Dr. Thompson and his colleagues measured the excitability and long-term potentiation between neurons from the brain of a rat, both before and after exposing slices of the brain's hippocampus to estrogen. The researchers looked specifically at the hormone's influence on a neurotransmitter called glutamate and two of its receptors, NMDA and AMPA. Neurotransmitters are chemicals that mediate the transmission of electrical impulses across the synapses between neurons.

"The estrogen activated both receptors within minutes -- causing a lasting increase in neuronal activity," Thompson reports. "Estrogen also enhanced the process of long-term potentiation. Activating the NMDA receptor apparently initiates long-term potentiation, and the AMPA receptors maintain it."

Since its discovery more than two decades ago, long-term potentiation has been intensively studied in hundreds of research laboratories around the world. The phenomenon is a long-lasting increase in neuronal responses in the hippocampus, a major structure in the forebrain of all mammals. It is thought to be a mechanism of memory shortage in the brain.

Thompson believes that learning more about the mechanism of long-term potentiation could lead to highly refined treatments for Alzheimer's disease. Researchers are studying compounds that are similar or related to estrogen in the hope of finding a drug precisely targeted for the treatment of disease while avoiding unwanted side-effects.

USC neur

Contact: Bob Calverley
University of Southern California

Page: 1 2

Related medicine news :

1. Mayo Clinic researchers restore lost immunity -- Possible breakthrough for AIDS
2. Possible brain cancer-air pollution link to be studied
3. Possible new cancer therapy shrinks tumors in melanoma patients, Science authors report
4. Possible outpatient relief for millions of older men: MD researcher develops improved technology to shrink enlarged prostate glands without surgery
5. Possible link between heart attack and helicobacter pylori infection
6. UI Researchers Identify Possible Reason For Rare, Accelerated Aging Condition
7. New Procedure Makes A Successful Transplant Possible
8. Future Chlamydia Screening Should Take Account Of Possible Disadvantages For Women
9. UF Researchers Cite Possible Link Between Autism, Schizophrenia And Diet
10. More Evidence Of Possible Adverse Effects From New Hormone Use In Women With Heart Disease
11. Commercial Scale Cultivation Of Pharmaceutical-Producing Tobacco Possible, Virginia Tech Scientists Find

Post Your Comments:

(Date:6/25/2016)... ... ... Austin residents seeking Mohs surgery services, can now turn to Dr. Jessica Scruggs ... for medical and surgical dermatology. , Dr. Dorsey brings specialization to include Mohs surgery, ... Micrographic Surgery completed by Dr. Dorsey was under the direction of Glenn Goldstein, MD, ...
(Date:6/25/2016)... ... 25, 2016 , ... First Choice Emergency Room , the largest network ... the Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased ... location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health ... of their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards ... at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic ... many turn to unhealthy avenues, such as drug or alcohol abuse, as a coping ... released tools for healthy coping following a traumatic event. , Trauma sufferers tend to ...
(Date:6/24/2016)... ... 2016 , ... The Pulmonary Hypertension Association (PHA) learned during ... two significant new grants to support its work to advance research and patient ... recognizing patients, medical professionals and scientists for their work in fighting pulmonary hypertension ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Research and Markets has announced the addition of ... report to their offering. ... The World Market for Companion Diagnostics covers the world market ... the report includes the following: , World ... Region (N. America, EU, ROW), 2015-2020 , World IVD ...
(Date:6/24/2016)...   Pulmatrix, Inc ., (NASDAQ: PULM ... announced today that it was added to the Russell ... comprehensive set of U.S. and global equity indexes on ... milestone for Pulmatrix," said Chief Executive Officer Robert ... progress in developing drugs for crucial unmet medical needs, ...
(Date:6/24/2016)...  Arkis BioSciences, a leading innovator in the ... cerebrospinal fluid treatments, today announced it has secured ... led by Innova Memphis, followed by Angel Capital ... Arkis, new financing will accelerate the commercialization of ... of its in-licensed Endexo® technology. ...
Breaking Medicine Technology:
Cached News: