HOME >> MEDICINE >> NEWS
Possible Mechanism For Estrogen Memory Enhancement Found

University of Southern California neuroscientists have found a chemical mechanism that explains how estrogen enhances the process believed responsible for memory.

"Previous studies have suggested that the hormone estrogen delays the onset of Alzheimer's disease, and several million post-menopausal women are taking estrogen supplements for that reason," says USC neurophysiologist Richard F. Thompson, Ph.D. "Our research reveals a chemical mechanism that could explain how the delay in onset occurs."

Dr. Thompson and his colleagues measured the excitability and long-term potentiation between neurons from the brain of a rat, both before and after exposing slices of the brain's hippocampus to estrogen. The researchers looked specifically at the hormone's influence on a neurotransmitter called glutamate and two of its receptors, NMDA and AMPA. Neurotransmitters are chemicals that mediate the transmission of electrical impulses across the synapses between neurons.

"The estrogen activated both receptors within minutes -- causing a lasting increase in neuronal activity," Thompson reports. "Estrogen also enhanced the process of long-term potentiation. Activating the NMDA receptor apparently initiates long-term potentiation, and the AMPA receptors maintain it."

Since its discovery more than two decades ago, long-term potentiation has been intensively studied in hundreds of research laboratories around the world. The phenomenon is a long-lasting increase in neuronal responses in the hippocampus, a major structure in the forebrain of all mammals. It is thought to be a mechanism of memory shortage in the brain.

Thompson believes that learning more about the mechanism of long-term potentiation could lead to highly refined treatments for Alzheimer's disease. Researchers are studying compounds that are similar or related to estrogen in the hope of finding a drug precisely targeted for the treatment of disease while avoiding unwanted side-effects.

USC neur
'"/>

Contact: Bob Calverley
calverle@usc.edu
213-740-4750
University of Southern California
17-Mar-1999


Page: 1 2

Related medicine news :

1. Mayo Clinic researchers restore lost immunity -- Possible breakthrough for AIDS
2. Possible brain cancer-air pollution link to be studied
3. Possible new cancer therapy shrinks tumors in melanoma patients, Science authors report
4. Possible outpatient relief for millions of older men: MD researcher develops improved technology to shrink enlarged prostate glands without surgery
5. Possible link between heart attack and helicobacter pylori infection
6. UI Researchers Identify Possible Reason For Rare, Accelerated Aging Condition
7. New Procedure Makes A Successful Transplant Possible
8. Future Chlamydia Screening Should Take Account Of Possible Disadvantages For Women
9. UF Researchers Cite Possible Link Between Autism, Schizophrenia And Diet
10. More Evidence Of Possible Adverse Effects From New Hormone Use In Women With Heart Disease
11. Commercial Scale Cultivation Of Pharmaceutical-Producing Tobacco Possible, Virginia Tech Scientists Find

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Possible Mechanism For Estrogen Memory Enhancement Found

(Date:12/20/2014)... Weddingshe.com has recently announced its new collection of sweet ... occasion dresses for the coming new year. , ... for global women. Now, all the models on its ... off. Among the new items, the model of 10986064 ... very popular. What’s more, Weddingshe.com also provides a fast ...
(Date:12/20/2014)... holidays can be anything but joyous for people with ... and other allergy triggers. "The dust from the ... away in dank basements or dusty attics is triggering ... Shah, an affiliate faculty member at Loyola University Chicago ... Shah, who is also an allergist at Gottlieb ...
(Date:12/20/2014)... Atore, Inc, (San Francisco, CA CEO: ... birthday focused portal on December 17th, 2014. , ... both US and Japan. , MERRY BIRTHDAY SITE : ... , MERRY BIRTHDAY MESSAGE is part of 5 ... , Features, Choose from thousands of stock photos to ...
(Date:12/20/2014)... The Twin Cities DI Day is ... the nation! Over 250 financial professionals come together each ... the industry, get motivated to protect their clients and ... and overcoming the challenges of disability. , On September ... came together to attend The 13th Annual Twin Cities ...
(Date:12/19/2014)... Sweetdressy.com , a leading wedding dress manufacturer for ... cheap prom dresses for ladies worldwide. The prom dresses ... clients can buy these dresses at the website of ... cuts and delicate craftsmanship, and most of them are ... shipping costs are available for all of their dresses. ...
Breaking Medicine News(10 mins):Health News:Tons of New-in Winter Sweet 16 Dresses from Weddingshe Online Now 2Health News:Holiday Trimmings Can Trigger Allergies 2Health News:Atore, Inc. Releasing the First Birthday Portal 2Health News:The 13th Annual Twin Cities DI Day Now On Video 2Health News:The 13th Annual Twin Cities DI Day Now On Video 3Health News:Cheap Prom Dresses Online Now at Sweetdressy.com 2
(Date:12/19/2014)... , Dec. 19, 2014 You,re visiting ... checkup and cleaning when he or she says you ... probably heard before, you may have several questions and ... be relieved to know it,s nothing to worry about. ... patients, questions and alleviate any anxiety the public may ...
(Date:12/19/2014)... 2014 In today,s increasingly global marketplace ... to reflect the needs of a global marketplace ... the needs of key stakeholders while recognizing regional ... According to recent research by benchmarking firm, Best ... companies averaged more than $100,000 in annual spending ...
(Date:12/19/2014)... FORT WORTH, Texas , December 18, 2014 ... is a networked software application/module that is used ... and related images. RIS comprises a patient tracking ... tracking system. The integration of RIS with HIS ... is used for patient registration and patient scheduling, ...
Breaking Medicine Technology:Root Canals Have Become More Routine 2Building a Best-in-Class Pharma Global Brand Website 2The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 2The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 3
Cached News: