HOME >> MEDICINE >> NEWS
Postmenopausal hormone therapy offers no protection against heart attacks

Although therapy with hormones was once thought to protect women's hearts after menopause, a UCSF-led study has found that, at least for women with heart disease, estrogen plus progestin therapy does not reduce the risk of heart attack or death.

The July 3, 2002 issue of the Journal of the American Medical Association (JAMA) contains two articles with the results of the Heart and Estrogen/Progestin Replacement Follow-up Study (HERS II).

HERS was a randomized, blinded trial to determine the effects of estrogen plus progestin (compared with placebo) in older postmenopausal women with heart disease. In 1998 HERS scientists reported that, surprisingly, risk of heart attack increased in the hormone therapy group during the first year of HERS. The risk seemed to decrease in the next several years, leading to the HERS II follow-up study to evaluate the effects of longer-duration hormone therapy.

The trend toward a reduced risk of heart attacks did not persist with additional follow-up. During almost 7 years, combining HERS and HERS II, there was no reduction in risk among women taking hormones.

"This follow-up study found no reduction in risk of heart attacks or death for women with heart disease during up to seven years of hormone therapy. Not only was there no cardiovascular benefit, there were adverse affects, including blood clots and gallbladder disease," said Deborah Grady, MD, MPH, UCSF professor of epidemiology and medicine and co-principal investigator on the studies. Grady is also director of the UCSF/Mount Zion Women's Health Clinical Research Center.

The hormone therapy caused a 2-fold increase in the risk of blood clots in the legs and lungs, with most of the increased risk in the early years of treatment, according to principal investigator Stephen Hulley, MD, MPH, professor and chair of the UCSF department of epidemiology and biostatistics. There was a nearly 50 percent increase in the risk of gallbladder disease r
'"/>

Contact: Maureen McInaney
mmcinaney@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
2-Jul-2002


Page: 1 2

Related medicine news :

1. Postmenopausal breast cancer survivors at increased risk for bone fractures
2. Postmenopausal women have lower grip strength than premenopausal women
3. Postmenopausal hormone therapy associated with increased risk for developing asthma
4. Postmenopausal hormone replacement therapy linked to increased risk for certain types of rarely occurring breast cancer
5. Postmenopausal Women Reap Heart Benefits From Foods Containing Vitamin E
6. Novel Therapy Significantly Reduces Spinal Fractures In Postmenopausal WomenWith Two Years Of Therapy
7. New Drug Prevents Breast Cancer In Postmenopausal Women, UCSF Researchers Report
8. Growth hormone treatment improves symptoms of metabolic disorder in postmenopausal women
9. Mood elevating hormone may trigger depression and heart problems
10. The history and controversy behind post-menopausal hormone therapy
11. Female sex hormones play a vital role in defense against sexually transmitted diseases

Post Your Comments:
(Date:9/2/2015)... ... September 02, 2015 , ... ... large stream of mixed documents that include EOBs, payments, and payment related documents. ... the data needed to reconcile their billing, with one efficient process and interface,“ ...
(Date:9/2/2015)... Pittsburgh, PA (PRWEB) , ... September 02, 2015 ... ... the Health Sciences clinical and academic partnership has earned international recognition as a ... rare genetic disorder that can cause sudden, catastrophic internal bleeding and stroke. ...
(Date:9/2/2015)... ... September 02, 2015 , ... ... largest and fastest-growing interim clinical staffing companies, has completed a recapitalization with ... , BPOC and Heritage Group each offer extensive expertise and ...
(Date:9/2/2015)... Kansas City, KS (PRWEB) , ... September 02, 2015 , ... ... recently opened its newest office in Kansas – its Johnson County location. ... backgrounds in healthcare. Mike has a registered nurse background and spent over 20 years ...
(Date:9/2/2015)... ... September 02, 2015 , ... Ovarian cancer continues to be ... risk of getting ovarian cancer in her lifetime is approximately 1 in 75. This ... ovarian cancer, and 14,000 will die. , There is no test to detect ...
Breaking Medicine News(10 mins):Health News:AliusDoc Launches Enhanced AD-EOB A/R Data Capture Solution to Streamline Processing of Payment-Related Documents Together with EOBs 2Health News:UPMC-University of Pittsburgh Named Center of Excellence for Rare Disorder 2Health News:UPMC-University of Pittsburgh Named Center of Excellence for Rare Disorder 3Health News:UPMC-University of Pittsburgh Named Center of Excellence for Rare Disorder 4Health News:Medical Solutions Completes Recapitalization with Beecken Petty O’Keefe & Company and Heritage Group 2Health News:Medical Solutions Completes Recapitalization with Beecken Petty O’Keefe & Company and Heritage Group 3Health News:Medical Solutions Completes Recapitalization with Beecken Petty O’Keefe & Company and Heritage Group 4Health News:Amada Senior Care Expands to Greater Kansas City 2Health News:National Ovarian Cancer Coalition's DFW Chapter Features First Annual Teal Lights Display This Friday, September 4th, "National Wear Teal Day" 2Health News:National Ovarian Cancer Coalition's DFW Chapter Features First Annual Teal Lights Display This Friday, September 4th, "National Wear Teal Day" 3
(Date:9/2/2015)... 2, 2015 Demers Ambulances is proud to announce ... new dealer for the states of Mississippi ... . "This will enable Demers to ... Lafortune , Executive Vice-President for Demers Ambulances. "Emergency Equipment Professionals ... and Alabama , giving them a ...
(Date:9/2/2015)...  MiMedx Group, Inc. (NASDAQ: MDXG ), ... tissue and patent-protected processes to develop and market ... Surgical, Orthopedic, Spine, Sports Medicine, Ophthalmic and Dental ... published by the Musculoskeletal Transplant Foundation ("MTF") in ... MTF,s September 1st press release characterizes the ...
(Date:9/2/2015)... , Sept. 2, 2015 Unilife Corporation ("Unilife" ... UNS), a developer, manufacturer and supplier of injectable drug ... initiated expressions of interest, the Company,s Board of Directors ... a review of strategic alternatives to maximize shareholder value. ... and evaluated during the review process may include a ...
Breaking Medicine Technology:Demers Ambulances has named Emergency Equipment Professionals (EEP) Inc. as their dealer for the states of MS, AL and TN 2MiMedx Corrects A Second Inaccurate MTF Press Release 2MiMedx Corrects A Second Inaccurate MTF Press Release 3Unilife Announces Review of Strategic Alternatives 2
Cached News: