HOME >> MEDICINE >> NEWS
Potential drug target for treating cocaine abuse found

WASHINGTON, DC February 17, 2005 -- A substance similar to a drug used in the treatment of Parkinson's disease blocks the stimulating effects of cocaine and could potentially be used to develop drug therapy for cocaine abuse, new research shows.

In an article published in the February 23, 2005, issue of The Journal of Neuroscience, Jonathan Katz and his colleagues at the National Institute on Drug Abuse (NIDA) report the results of experiments showing that mice treated with a substance similar to the drug benztropine did not show any of the typical hyperactive behavior when later injected with cocaine. This effect wore off after a day.

Cocaine produces intense feelings of euphoria by increasing the amount of dopamine that is sent from one neuron to another within the brain reward system. Dopamine signals pleasure and reward by binding to receptors on the receiving neurons, after which it is reabsorbed for later use by a protein that transports it back into the sending neuron. But cocaine blocks the mechanism that transports dopamine, causing it to build up and send an unceasing message of pleasure the cocaine high.

Researchers have long searched for "a molecule that would block cocaine's effects on the transporter without inhibiting the transporter by itself," notes Eric Nestler, chair of psychiatry at the University of Texas Southwestern Medical Center in Dallas.

"This article reports early studies with just such a compound." Although the results are preliminary, this breakthrough shows that it may be possible to develop drugs that block cocaine's stimulating effects, and perhaps its power to addict, Nestler says.

Researchers previously thought that different chemicals that prevent the reabsorption of dopamine would all have the same stimulating effect on the brain. The new study shows this may not be true. "In fact, the interaction between dopamine trans-porters and the substances that bind to them may depend on the chemi
'"/>

Contact: Elissa Petruzzi
elissa@sfn.org
202-462-6688
Society for Neuroscience
22-Feb-2005


Page: 1 2

Related medicine news :

1. Potential treatment for Fragile X Syndrome demonstrated in fruit fly model
2. Potential cure for lymphoma in HIV patients
3. Potentially fatal toxicities occur with off-label use of cancer drugs
4. Potentially blinding eye disease more prevalent than previously thought
5. Potential genetic links discovered between metabolic syndrome, diabetes and cardiovascular disease
6. Potential low-cost options for monitoring HIV-1-infected children in less-developed countries
7. Immunexs TRAIL Molecule Shows Potential As Anti-Tumor Agent
8. Study Shows Potential For Quelling AIDS Nerve Pain
9. Polish Dumpling-Like Particle Has Potential In Drug Delivery
10. Increased Public Access To Defibrillation Could Prove Potentially Cost-Effective And Life-Saving
11. Anti-Clotting Drug May Cause Potentially Fatal Platelet Disorder

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2020)... ... March 28, 2020 , ... Confluent Health is proud ... therapist-owned rehabilitation company since 1985 specializing in the treatment of orthopedic, sports, and ... more than 30 years ago, we have been committed to providing excellent quality ...
(Date:3/27/2020)... ... March 27, 2020 , ... NeoTract, a ... the field of urology, today announced that Harpreet Wadhwa, M.D., East Valley Urology ... The designation recognizes that Dr. Wadhwa has achieved a high level of training ...
(Date:3/22/2020)... ... March 21, 2020 , ... In partnership with UC Health, Cincy Shirts has ... professionals and first responders. The title comes from the English translation of “Juncta Juvant”, ... flag. , Proceeds from the sale of the shirt will benefit the YMCA ...
(Date:3/22/2020)... ... March 22, 2020 , ... In times of crisis, like ... frivolous luxury. The world’s focus is on practical matters - on self-isolation, social ... and control in chaos. However, it’s during these times that “self-awareness” is crucial, ...
(Date:3/20/2020)... Quebec (PRWEB) , ... March 20, 2020 , ... ... to bring together an interdisciplinary team of researchers in machine learning, bioinformatics, immunology, ... deployed in current and future outbreaks. , "The COVID-19 crisis gives us an ...
Breaking Medicine News(10 mins):
(Date:4/1/2020)... ... April 01, 2020 , ... The new ... today, with the first live-streaming broadcast premiering on April 2. , The live ... interviewing a variety of animal keepers and veterinary hospital staff with different animals. ...
(Date:3/30/2020)... ... March 30, 2020 , ... CPSI ... TalkWithYourDoc.com . By leveraging technology developed by its wholly owned subsidiary, ... continue offering revenue-generating healthcare services while serving patients’ needs during the COVID-19 outbreak. ...
(Date:3/30/2020)... TRIANGLE PARK, N.C. (PRWEB) , ... March 30, ... ... and operations, today announced it has been recognized by Dresner Advisory Services as ... recognizes Zaloni for its capabilities related to data orchestration, data transformation, and data ...
Breaking Medicine Technology:
Cached News: