HOME >> MEDICINE >> NEWS
Predicting risk of poor outcomes in patients with heart disease using certain biomarker

Levels of the biomarker placental growth factor (PlGF) in the blood may predict the risk of heart attack or death for patients with coronary heart disease, according to a study in the January 28 issue of The Journal of the American Medical Association (JAMA).

According to background information in the article, PlGF, a member of the vascular growth factor family, acts as a primary inflammatory instigator of atherosclerotic (hardening and narrowing of the arteries) plaque instability and thus may be useful as a risk-predicting biomarker in patients with acute coronary syndromes (ACS).

Christopher Heeschen, M.D., of Johann Wolfgang Goethe University, Frankfurt, Germany and colleagues conducted a study to determine whether blood levels of PlGF predict risk for death or nonfatal heart attack in patients with acute chest pain. Various measurements were taken of 547 patients with angiographically validated ACS participating in the CAPTURE (c7E3 Fab Anti-Platelet Therapy in Unstable Refractory Angina) trial and in a cohort of 626 patients presenting with acute chest pain to an emergency department in Germany between December 1996 and March 1999.

In patients with ACS, elevated PlGF levels indicated a markedly increased risk of heart attack or death at 30 days (14.8 percent vs. 4.9 percent; more than three times increased risk). In patients with acute chest pain, elevated levels of PlGF predicted three fold increased risk of heart attack or death (21.2 percent vs. 5.3 percent).

The authors write that "... elevated PlGF levels did not only identify those patients with acute chest pain who developed ACS, but also those patients with an increased risk of recurrent instability after hospital discharge."

"In summary, PlGF plasma levels represent a potentially powerful clinical biomarker of vascular inflammation and adverse outcome in patients with ACS. Measuring PlGF levels may extend the predictive and prognostic information gain
'"/>

Contact: Christopher Heeschen, M.D.
c.heeschen@em.uni-frankfurt.de
JAMA and Archives Journals
27-Jan-2004


Page: 1 2

Related medicine news :

1. Predicting who is most likely to quit smoking
2. Acute Urinary Retention And BPH-Related Surgery: Predicting Those At Highest Risk And Prevention With Finasteride
3. KUMC Researchers Announce Breakthrough Method For Predicting Epileptic Seizures
4. Oral bacteria may predict pregnancy outcomes
5. Medicaid enrollment at late stages may partly explain poor outcomes for cancer
6. New imaging technologies can enhance orthopaedic outcomes
7. Columbia study finds hemophilia therapy dramatically improves outcomes for bleeding stroke
8. Computer model being developed at Stanford may help surgeons better predict patient outcomes
9. Vaginal hysterectomy leads to better outcomes than abdominal surgery
10. Sit-down rounds improve outcomes for kidney dialysis patients
11. Infection in ELBW infants linked with poor neurodevelopmental, growth outcomes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Talented host, actor Rob Lowe, ... in a new episode of "Success Files," which is an award-winning educational program ... investigates each subject in-depth with passion and integrity. , Sciatica occurs when the ...
(Date:10/12/2017)... ... 2017 , ... First Healthcare Compliance (FHC), an industry leader ... range of technology and learning solutions at the 68th Annual American Healthcare Association ... held October 14–18, 2017 at the Mandalay Bay Resort in Las Vegas, Nevada. ...
(Date:10/12/2017)... ... ... IsoComforter, Inc. ( https://isocomforter.com ), one of the Nation’s premier ... of the shoulder pad. The shoulder pad provides optimal support and full contact ... using cold therapy. By utilizing ice and water that is circulated from an insulated ...
(Date:10/12/2017)... ... 2017 , ... Dr. Parsa Mohebi, the Los Angeles based ... the newly revamped Cosmetic Town journal section, featuring articles written by ... as Follicular Unit Extraction (FUE). , Dr. Mohebi says “I enjoy ...
(Date:10/12/2017)... GRAND RAPIDS, Mich. (PRWEB) , ... October 12, ... ... OnSite Wellness, has been named one of Michigan’s 2017 Best and Brightest in ... Best and Brightest in Wellness® awards program on Friday, Oct. 20 from 7:30 ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)...  Commended for their devotion to personalized service, SMP Pharmacy ... one in the South Florida Business Journal,s 50 Fastest-Growing Companies, ... list, the national specialty pharmacy has found its niche.  To ... soon be honored by SFBJ as the 2017 Power Leader ... to receive his award in October, Bardisa said of the ...
(Date:9/25/2017)... 2017   Montrium , an industry leader ... the IQPC Trial Master Files & Inspection Readiness ... EastHORN Clinical Services has selected eTMF Connect ... management. EastHORN, a leading European contract research organization ... transparency to enable greater collaboration with sponsors, improve ...
(Date:9/23/2017)... Sept. 22, 2017 Janssen Biotech, Inc. (Janssen) ... letter from the U.S. Food and Drug Administration (FDA) ... sirukumab for the treatment of moderately to severely active ... clinical data are needed to further evaluate the safety ... active RA. ...
Breaking Medicine Technology:
Cached News: