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Preliminary study shows high-dose coenzyme Q10 slows functional decline in Parkinson's patients

d developed by David Oakes, Ph.D., biostatistician for the study and chair of the Department of Biostatistics at the University of Rochester, in collaboration with Shults and Drs. Ira Shoulson and Karl Kieburtz of the University of Rochester.

Shults stated that he hoped this study and its efficient design will stimulate future studies to identify treatments that are likely to slow the progression of Parkinson's disease.

Listed according to number of subjects enrolled, the investigators and trial sites for the recent study were:

  • Julie Carter, R.N., M.N., A.N.P., Oregon Health & Science University
  • Katie Kompoliti, M.D., Rush-Presbyterian-St. Luke's Medical Center
  • Joel S. Perlmutter, M.D., Washington University in St. Louis
  • Stephen Reich, M.D., Johns Hopkins University
  • Matthew Stern, M.D., University of Pennsylvania
  • Ray L. Watts, M.D., Emory University
  • Roger Kurlan, M.D., University of Rochester
  • Eric Molho, M.D., Albany Medical College
  • Madaline Harrison, M.D., University of Virginia
  • Mark Lew, M.D., Keck School of Medicine of the University of Southern California.

Shults and his colleagues strongly caution patients against choosing to take coenzyme Q10 until a larger, definitive trial can be conducted. Because coenzyme Q10 is classified as a dietary supplement, it is not regulated by the U.S. Food and Drug Administration. The versions of the coenzyme Q10 sold in stores may differ and may not contain potentially beneficial amounts of the compound, Shults said. He added that if many people begin taking coenzyme Q10 after these early results, it may make it impossible for investigators to find enough patients to carry out definitive studies of the compound's effectiveness and the proper dosages, since patients must not be taking any treatments in order to be considered for enrollment in a definitive trial.


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Contact: Sue Pondrom
spondrom@ucsd.edu
619-543-6163
University of California - San Diego
14-Oct-2002


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