HOME >> MEDICINE >> NEWS
Prenatal stem cell transplants may open door to organ transplants, treating genetic diseases

Philadelphia, Pa. In a finding that could open the door to future treatments for many genetic diseases such as sickle cell anemia and muscular dystrophy, researchers have produced high levels of transplanted, healthy stem cells in mice, while sharply reducing a hazardous side effect of cell and organ transplants called graft-versus-host disease.

By combining prenatal transplants of blood-forming stem cells with manipulations of blood cells after birth, researchers at The Children's Hospital of Philadelphia achieved immune tolerance in mice, allowing donor cells to multiply without toxic side effects. The studies appear in related articles in the August and September issues of Blood.

The finding could greatly broaden the use of cell and organ transplants for genetic diseases detected before birth, such as leukemia, sickle cell disease, muscular dystrophy, and some kidney and liver disorders.

"Recent developments in genetic knowledge and technology are converging to make it likely that within a decade, nearly all human genetic diseases will be diagnosed before birth," says Alan W. Flake, M.D., director of the Children's Institute for Surgical Science at The Children's Hospital of Philadelphia, and senior author of both articles. "Our research may greatly expand our ability to use prenatal interventions to help the body safely tolerate treatments for genetic diseases."

Dr. Flake's team used a prenatal procedure called in utero hematopoietic stem cell transplantation (IUHSCT). Hematopoietic stem cells develop into red blood cells, white blood cells and a variety of immune cells. The stem cells used in these studies were taken from the bone marrow of adult mice, not from human embryos.

As a disease treatment, prenatal stem cell transplants have faced a major barrier in that they have been unable to achieve high levels of engraftment the number of donor stem cells usually does not grow large enough to overcome the effect of dis
'"/>

Contact: John Ascenzi
ascenzi@email.chop.edu
215-590-7332
Children's Hospital of Philadelphia
6-Nov-2002


Page: 1 2 3 4

Related medicine news :

1. Prenatal alcohol exposure has effects far beyond fetal alcohol syndrome
2. Prenatal zinc supplementation could impair childhood mental development
3. Cedars-Sinai Medical Centers Prenatal Program Pushes the Frontiers of Diagnosis From the Second Trimester Into the First
4. Prenatal Smoking Leads To Antisocial Behavior In Children
5. Prenatal Cocaine Exposure Leads To Lower Child IQ Scores, Language Skills
6. Cornea transplants can be improved
7. Hard choices: Pitt researcher presents findings on when to accept organ transplants
8. Study explores risks of obesity in children with kidney transplants
9. Kinder, gentler procedure gives superior results for stem cell transplants
10. Multi-center study finds therapy boosts kidney transplants in highly sensitized patients
11. Artery variations increase complication risk in liver transplants

Post Your Comments:
(Date:8/27/2014)... August 27, 2014 ANS ... a ground breaking anti-cancer therapy for the treatment of ... to prescribe this new medical therapy and will begin ... starting immediately. , NovoTTF™ Therapy is a portable, non-invasive ... 22 years of age and older. It is a ...
(Date:8/27/2014)... August 27, 2014 Ticket Down is a ... at Sun Life Stadium in Miami. The Brazilian national ... on September 5 at Sun Life Stadium in Miami Gardens, ... a rematch of the World Cup earlier this year when ... to injury. The Brazilian Soccer Federation announced earlier this week ...
(Date:8/27/2014)... New York (PRWEB) August 27, 2014 ... filed in U.S. courts on behalf of women who ... uterine morcellation, Bernstein Liebhard LLP reports. According to court ... on August 18th in the U.S. District Court, Northern ... patient who claims the use of a power morcellator ...
(Date:8/27/2014)... NC. SonaCare Medical, LLC, the global ... sales of 15 HIFU devices over the past twelve ... for the company’s ablation technology. , “It is ... achieved over the past year, especially since we are ... our most active sales period,” says Mike Klein, CEO ...
(Date:8/27/2014)... inherited from our parents shapes many aspects of our ... an epigenome that is set during development, but can ... perhaps by those of our parents and grandparents. , ... and supporting proteins that determine whether genes are expressed ... for our own health, but also that it may ...
Breaking Medicine News(10 mins):Health News:Atlantic NeuroSurgical Specialists (ANS) Announces Availability of New Therapy for Brain Cancer 2Health News:Atlantic NeuroSurgical Specialists (ANS) Announces Availability of New Therapy for Brain Cancer 3Health News:Brazil vs. Colombia Tickets in Miami, FL: Ticket Down Cuts Ticket Prices on World Cup Rematch of Colombia vs. Brazil at Sun Life Stadium in Miami on Sept. 5th 2Health News:Brazil vs. Colombia Tickets in Miami, FL: Ticket Down Cuts Ticket Prices on World Cup Rematch of Colombia vs. Brazil at Sun Life Stadium in Miami on Sept. 5th 3Health News:Power Morcellator Lawsuit Alleges Storz Morcellator Caused Spread of Aggressive Uterine Cancer, Bernstein Liebhard LLP Reports 2Health News:Power Morcellator Lawsuit Alleges Storz Morcellator Caused Spread of Aggressive Uterine Cancer, Bernstein Liebhard LLP Reports 3Health News:Power Morcellator Lawsuit Alleges Storz Morcellator Caused Spread of Aggressive Uterine Cancer, Bernstein Liebhard LLP Reports 4Health News:SonaCare Medical Announces Twelve Months Sales Results of Fifteen HIFU Devices 2Health News:Scientists map the 'editing marks' on fly, worm, human genomes 2Health News:Scientists map the 'editing marks' on fly, worm, human genomes 3Health News:Scientists map the 'editing marks' on fly, worm, human genomes 4
(Date:8/27/2014)... 27, 2014   Los Angeles orthodontics expert, ... to patients who want to make their treatment even ... the OrthoSpaceship, all patients have a powerful tool to ... can be used by most patients with all types ... by using the AcceleDent® Aura system for a few ...
(Date:8/27/2014)... 27, 2014 By now, if you haven,t heard ... on this planet. The awareness campaign has brought this devastating ... to raise over $88.5 Million (and counting) for ALS. Every ... companies are starting to as well. One such ... , who actually works with ALS sufferers and helps ...
(Date:8/27/2014)... , August 27, 2014 ResearchMoz ... States  Laparoscopes Market Outlook to 2020. New report, ... market data on the United States Laparoscopes market ... dollars, volume (in units) and average prices (in US ... Laparoscopes and Flexible Tip Video Laparoscopes), Robotic Surgical Systems ...
Breaking Medicine Technology:Los Angeles Orthodontist, Dr. Isaac Hakim, is Now Offering AcceleDent Aura 2Acorn Stairlifts Gives a Lift to the ALS Ice Bucket Challenge 2United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 2United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 3United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 4United States Laparoscopes Market Outlook, Analysis, Size, Share, Growth, Trends And Forecast 2020 5
Cached News: