Prenatal stem cell transplants may open door to organ transplants, treating genetic diseases

Philadelphia, Pa. In a finding that could open the door to future treatments for many genetic diseases such as sickle cell anemia and muscular dystrophy, researchers have produced high levels of transplanted, healthy stem cells in mice, while sharply reducing a hazardous side effect of cell and organ transplants called graft-versus-host disease.

By combining prenatal transplants of blood-forming stem cells with manipulations of blood cells after birth, researchers at The Children's Hospital of Philadelphia achieved immune tolerance in mice, allowing donor cells to multiply without toxic side effects. The studies appear in related articles in the August and September issues of Blood.

The finding could greatly broaden the use of cell and organ transplants for genetic diseases detected before birth, such as leukemia, sickle cell disease, muscular dystrophy, and some kidney and liver disorders.

"Recent developments in genetic knowledge and technology are converging to make it likely that within a decade, nearly all human genetic diseases will be diagnosed before birth," says Alan W. Flake, M.D., director of the Children's Institute for Surgical Science at The Children's Hospital of Philadelphia, and senior author of both articles. "Our research may greatly expand our ability to use prenatal interventions to help the body safely tolerate treatments for genetic diseases."

Dr. Flake's team used a prenatal procedure called in utero hematopoietic stem cell transplantation (IUHSCT). Hematopoietic stem cells develop into red blood cells, white blood cells and a variety of immune cells. The stem cells used in these studies were taken from the bone marrow of adult mice, not from human embryos.

As a disease treatment, prenatal stem cell transplants have faced a major barrier in that they have been unable to achieve high levels of engraftment the number of donor stem cells usually does not grow large enough to overcome the effect of dis

Contact: John Ascenzi
Children's Hospital of Philadelphia

Page: 1 2 3 4

Related medicine news :

1. Prenatal alcohol exposure has effects far beyond fetal alcohol syndrome
2. Prenatal zinc supplementation could impair childhood mental development
3. Cedars-Sinai Medical Centers Prenatal Program Pushes the Frontiers of Diagnosis From the Second Trimester Into the First
4. Prenatal Smoking Leads To Antisocial Behavior In Children
5. Prenatal Cocaine Exposure Leads To Lower Child IQ Scores, Language Skills
6. Cornea transplants can be improved
7. Hard choices: Pitt researcher presents findings on when to accept organ transplants
8. Study explores risks of obesity in children with kidney transplants
9. Kinder, gentler procedure gives superior results for stem cell transplants
10. Multi-center study finds therapy boosts kidney transplants in highly sensitized patients
11. Artery variations increase complication risk in liver transplants

Post Your Comments:
(Date:10/9/2015)... ... October 09, 2015 , ... ... individuals from all walks of life to save money on the high cost ... $25 per month per medication, individuals and families can receive their medications delivered ...
(Date:10/9/2015)... ... 2015 , ... Ryan Fox, the founder and CEO of ... says the latest figures on the state’s sales of legalized marijuana acknowledge that ... , Last month, according to the website AllGov.com , Colorado's Department ...
(Date:10/9/2015)... ... ... was featured on NewsWatch as part of its monthly Tech Report, which features the ... special reporter for NewsWatch, conducted the review and shared with viewers how this security ... it’s more important than ever to keep homes and dorms safe and protected. That ...
(Date:10/9/2015)... , ... October 09, 2015 , ... Dignity Health named ... General Hospital Emergency Room – Chandler–McQueen opening later this month. The new ... this year in the West Valley. , “Dr. Morro is an excellent leader ...
(Date:10/9/2015)... ... 09, 2015 , ... Yisrayl Hawkins, Pastor at The House of Yahweh in ... health care back to the beginning, literally, starting in the book of Genesis. ... if only biblical laws were being taught. The letter addresses the many types ...
Breaking Medicine News(10 mins):
(Date:10/9/2015)... , Oct. 9, 2015 Ansun BioPharma ... Disease Society of America ) regarding the compassionate use ... patient on a respirator who was co-infected with influenza ... five-day course of therapy, O 2 requirement was ... patient was able to go off the respirator on ...
(Date:10/9/2015)... ,JCA-Mauvernay Award 2015, se ha otorgado a los doctores ... Takita    --> El ,JCA-Mauvernay Award 2015, ... y Junko Takita    --> ... los doctores Yutaka Kondo y ... con sede enSuiza, presentará el ,JCA-Mauvernay Award, el 10 de octubre a los ...
(Date:10/8/2015)... ® ) in adult ... NOCT study also assessed the compliance, safety, patient ... ® ) in adult patients undergoing screening, surveillance ... the compliance, safety, patient acceptability and tolerability of ... top line results for its phase III study, ...
Breaking Medicine Technology:
Cached News: