HOME >> MEDICINE >> NEWS
Prenatal stem cell transplants may open door to organ transplants, treating genetic diseases

Philadelphia, Pa. In a finding that could open the door to future treatments for many genetic diseases such as sickle cell anemia and muscular dystrophy, researchers have produced high levels of transplanted, healthy stem cells in mice, while sharply reducing a hazardous side effect of cell and organ transplants called graft-versus-host disease.

By combining prenatal transplants of blood-forming stem cells with manipulations of blood cells after birth, researchers at The Children's Hospital of Philadelphia achieved immune tolerance in mice, allowing donor cells to multiply without toxic side effects. The studies appear in related articles in the August and September issues of Blood.

The finding could greatly broaden the use of cell and organ transplants for genetic diseases detected before birth, such as leukemia, sickle cell disease, muscular dystrophy, and some kidney and liver disorders.

"Recent developments in genetic knowledge and technology are converging to make it likely that within a decade, nearly all human genetic diseases will be diagnosed before birth," says Alan W. Flake, M.D., director of the Children's Institute for Surgical Science at The Children's Hospital of Philadelphia, and senior author of both articles. "Our research may greatly expand our ability to use prenatal interventions to help the body safely tolerate treatments for genetic diseases."

Dr. Flake's team used a prenatal procedure called in utero hematopoietic stem cell transplantation (IUHSCT). Hematopoietic stem cells develop into red blood cells, white blood cells and a variety of immune cells. The stem cells used in these studies were taken from the bone marrow of adult mice, not from human embryos.

As a disease treatment, prenatal stem cell transplants have faced a major barrier in that they have been unable to achieve high levels of engraftment the number of donor stem cells usually does not grow large enough to overcome the effect of dis
'"/>

Contact: John Ascenzi
ascenzi@email.chop.edu
215-590-7332
Children's Hospital of Philadelphia
6-Nov-2002


Page: 1 2 3 4

Related medicine news :

1. Prenatal alcohol exposure has effects far beyond fetal alcohol syndrome
2. Prenatal zinc supplementation could impair childhood mental development
3. Cedars-Sinai Medical Centers Prenatal Program Pushes the Frontiers of Diagnosis From the Second Trimester Into the First
4. Prenatal Smoking Leads To Antisocial Behavior In Children
5. Prenatal Cocaine Exposure Leads To Lower Child IQ Scores, Language Skills
6. Cornea transplants can be improved
7. Hard choices: Pitt researcher presents findings on when to accept organ transplants
8. Study explores risks of obesity in children with kidney transplants
9. Kinder, gentler procedure gives superior results for stem cell transplants
10. Multi-center study finds therapy boosts kidney transplants in highly sensitized patients
11. Artery variations increase complication risk in liver transplants

Post Your Comments:
(Date:4/1/2015)... WI (PRWEB) April 01, 2015 When ... dryness occur, waiting days or weeks for an appointment ... Historically same and next day appointments haven’t been possible ... area, Forefront Dermatology’s offices have noticed demand for this ... , “We realize how important relief or answers to ...
(Date:4/1/2015)... GA (PRWEB) April 01, 2015 ... Medicine Practice, Pediatric Emergency Medicine Practice, and Hospital ... has partnered with AgileMD to provide the content ... , in a mobile application format available on ... , “Our collaboration with AgileMD to develop mobile ...
(Date:4/1/2015)... 01, 2015 On May 1, 2015, the ... annual Educational Institute in Albany, New York . This ... in nursing and feature an address by Helen R. Connors, ... Professor, University of Kansas School of Nursing and Center for ... being sponsored by the Excelsior College School of Nursing, ...
(Date:4/1/2015)... Washington, D.C. (PRWEB) April 01, 2015 It ... eaten solely for breakfast but now found wrapped around other ... products. Bacon has been called meat candy, the gateway meat ... as a cultural icon, the North American Meat Institute (NAMI) ... featuring a video tour of a bacon processing plant ...
(Date:4/1/2015)... 01, 2015 Natural fertility experts from ... attend the world’s first Integrative Fertility Symposium ( https://ifsymposium.com/ ... Centre (SFU Downtown Campus), 515 West Hastings Street, Vancouver ... Sunday, May 3rd, 3:00 pm to 5:00 pm at ... first of its kind in the world to bring ...
Breaking Medicine News(10 mins):Health News:Dermatology Associates of Wisconsin and Forefront Dermatology Answers Patients' Needs With Unmatched Availability In Sheboygan and Sheboygan Falls 2Health News:EB Medicine Partners With AgileMD on Mobile Application for Emergency Medicine Clinicians 2Health News:EB Medicine Partners With AgileMD on Mobile Application for Emergency Medicine Clinicians 3Health News:Excelsior College School of Nursing Educational Institute to Influence Nursing Empowerment 2Health News:Excelsior College School of Nursing Educational Institute to Influence Nursing Empowerment 3Health News:New Ultimate Guide to Bacon Video Provides Inside Look at How Bacon is Made 2Health News:Vancouver Hosts the World's First Integrative Fertility Symposium 2Health News:Vancouver Hosts the World's First Integrative Fertility Symposium 3
(Date:4/1/2015)...  Salix Pharmaceuticals, Ltd. ("Salix"), a wholly owned ... VRX ) (TSX:VRX), today announced that it will ... amount of its 6.00% Senior Notes due 2021, ... pursuant to two redemptions. On May 1, 2015, ... the Notes, and on May 4, 2015, Salix ...
(Date:4/1/2015)... 1, 2015   AMC Health , a leading ... in monitored care that are transforming chronic care and ... Conference. The conference will be held at McCormick ... 12 through 16. In addition to demonstrating its partnerships ... Health will share innovations that transform the way healthcare ...
(Date:4/1/2015)... N.J. , April 1, 2015  Janssen Therapeutics, ... recipients of funding from a special request for applications ... Drugs Living with HIV and/or Hepatitis C." ... each will receive a one-year charitable contribution to enhance ... drugs living with HIV and/or hepatitis C. ...
Breaking Medicine Technology:Redemption of All of Salix's Outstanding 6.00% Senior Notes due 2021 2Redemption of All of Salix's Outstanding 6.00% Senior Notes due 2021 3AMC Health Demonstrates Advances in Monitored Care at HIMSS 2015 2AMC Health Demonstrates Advances in Monitored Care at HIMSS 2015 3AMC Health Demonstrates Advances in Monitored Care at HIMSS 2015 4Janssen Therapeutics Announces Support for Organizations Focused on Improving Care and Treatment for People Who Inject Drugs Living with HIV and/or Hepatitis C 2Janssen Therapeutics Announces Support for Organizations Focused on Improving Care and Treatment for People Who Inject Drugs Living with HIV and/or Hepatitis C 3Janssen Therapeutics Announces Support for Organizations Focused on Improving Care and Treatment for People Who Inject Drugs Living with HIV and/or Hepatitis C 4
Cached News: