HOME >> MEDICINE >> NEWS
Prenatal stem cell transplants may open door to organ transplants, treating genetic diseases

Philadelphia, Pa. In a finding that could open the door to future treatments for many genetic diseases such as sickle cell anemia and muscular dystrophy, researchers have produced high levels of transplanted, healthy stem cells in mice, while sharply reducing a hazardous side effect of cell and organ transplants called graft-versus-host disease.

By combining prenatal transplants of blood-forming stem cells with manipulations of blood cells after birth, researchers at The Children's Hospital of Philadelphia achieved immune tolerance in mice, allowing donor cells to multiply without toxic side effects. The studies appear in related articles in the August and September issues of Blood.

The finding could greatly broaden the use of cell and organ transplants for genetic diseases detected before birth, such as leukemia, sickle cell disease, muscular dystrophy, and some kidney and liver disorders.

"Recent developments in genetic knowledge and technology are converging to make it likely that within a decade, nearly all human genetic diseases will be diagnosed before birth," says Alan W. Flake, M.D., director of the Children's Institute for Surgical Science at The Children's Hospital of Philadelphia, and senior author of both articles. "Our research may greatly expand our ability to use prenatal interventions to help the body safely tolerate treatments for genetic diseases."

Dr. Flake's team used a prenatal procedure called in utero hematopoietic stem cell transplantation (IUHSCT). Hematopoietic stem cells develop into red blood cells, white blood cells and a variety of immune cells. The stem cells used in these studies were taken from the bone marrow of adult mice, not from human embryos.

As a disease treatment, prenatal stem cell transplants have faced a major barrier in that they have been unable to achieve high levels of engraftment the number of donor stem cells usually does not grow large enough to overcome the effect of dis
'"/>

Contact: John Ascenzi
ascenzi@email.chop.edu
215-590-7332
Children's Hospital of Philadelphia
6-Nov-2002


Page: 1 2 3 4

Related medicine news :

1. Prenatal alcohol exposure has effects far beyond fetal alcohol syndrome
2. Prenatal zinc supplementation could impair childhood mental development
3. Cedars-Sinai Medical Centers Prenatal Program Pushes the Frontiers of Diagnosis From the Second Trimester Into the First
4. Prenatal Smoking Leads To Antisocial Behavior In Children
5. Prenatal Cocaine Exposure Leads To Lower Child IQ Scores, Language Skills
6. Cornea transplants can be improved
7. Hard choices: Pitt researcher presents findings on when to accept organ transplants
8. Study explores risks of obesity in children with kidney transplants
9. Kinder, gentler procedure gives superior results for stem cell transplants
10. Multi-center study finds therapy boosts kidney transplants in highly sensitized patients
11. Artery variations increase complication risk in liver transplants

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/22/2017)... ... 22, 2017 , ... Pullano Law Offices, a Chicago personal injury law firm, ... selected to serve as President of the North Suburban Bar Association for 2017-2018. Mr. ... hosted by the NSBA at the North Shore Country Club in Glenview, IL, on ...
(Date:9/22/2017)... ... September 22, 2017 , ... First ... is celebrating the one year anniversary of its Houston-Fallbrook facility. , “We ... Otinwa, Facility Medical Director of First Choice Emergency Room Houston-Fallbrook. “It has been ...
(Date:9/22/2017)... ... , ... “Fruit of the Spirit: “Love””: a delightful adventure of two ... “Fruit of the Spirit: “Love”” is the creation of published author, Halimah Jones, who ... five. Halimah is an avid writer, her inspiration for “Fruit of the Spirit: “Love”” ...
(Date:9/22/2017)... ... September 22, 2017 , ... Egg freezing ... Although frozen embryos have a slight statistical advantage for live births, frozen eggs ... wonderful opportunity for women undergoing medical treatment or who are concerned about the ...
(Date:9/21/2017)... ... September 21, 2017 , ... 38-Year-Old Plastic Surgeon Gill at Aesthetic Surgery ... is pleased to announce that Plastic Surgeon Kiranjeet Gill has been awarded as one ... is an annual award that was started in 2003 to salute young achievers in ...
Breaking Medicine News(10 mins):
(Date:9/19/2017)... , Sept. 19, 2017   ZirMed Inc ., a ... today announced that it has been ranked #1 by its ... Book™ Rankings 2017 User Survey. ZirMed was recognized as ... large hospitals and medical centers over 200 beds and holds ... healthcare technology user survey history. ...
(Date:9/12/2017)... PARIS and NEW YORK , Sept. 12, ... ethical performance ratings for global supply chains, has published the first annual ... the CSR performance of more than 20,400 companies evaluated by EcoVadis, based ... years 2015 and 2016. ... EcoVadis Global CSR Risk & Performance Index ...
(Date:9/9/2017)... NEW YORK , Sept. 8, 2017 ... largest independent supplier of medical equipment, supplies, drugs, ... that it has entered into an agreement to acquire ... surgical equipment based in Holtsville, New York ... which specializes in supplying new and emerging medical practices, ...
Breaking Medicine Technology:
Cached News: